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Oxford Parkinson's Disease Centre Logo: the OPDC is funded by Parkinson's UK. Change attitudes. Find a cure. Join us.

The Oxford Parkinson's Disease Centre offers attractive opportunities to work with leading researchers in advancing the understanding of Parkinson's. 

CURRENT VACANCIES

Post-doctoral Research Assistant neuronal biologist: “Biomarkers of lysosomal dysfunction in Parkinson’s disease
Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford, OX1 3PT
Full-time, Fixed-term for 2 years
 
Applications are invited for a post-doctoral neuronal biologist to work on biomarker profiles of lysosomal dysfunction in pre-clinical models of Parkinson’s. The project, funded by the Michael J Fox Foundation and in collaboration with EndLyz, a new company within the Dementia Discovery Fund (DDF) portfolio, represents an exciting opportunity to undertake translational work at the interface between academic research and pharmaceutical target and drug discovery in an exceptional setting. The project will examine metabolomic biomarkers of endolysosomal dysfunction to better understand mechanisms of disease pathology, and to establish how the biomarker profile may change on treatment with potential therapeutic compounds.
Duties include design and implementation of experiments; interpretation of data; metabolomic profiling in Parkinson’s transgenic mouse models; biochemistry, immunohistochemistry and molecular neuropathology studies in brain samples from transgenic mice; preparation of data for publication; contribute ideas for new research projects and develop ideas for generating research income; manage own academic research involving small-scale project management and act as a source of information to other members of the group.
You will have excellent knowledge and practical experience of working with pre-clinical transgenic models of neurodegenerative disease. The ability to innovate, trouble-shoot technical problems, be meticulous in practical work and in record keeping is also essential. Applicants must hold, or be near completion of, a PhD/DPhil in a relevant area of research and have experience in cellular neuroscience, and molecular cell biology relevant to analysis of neuronal phenotypes.
 
The post is available for two years from 1st January 2024. The post will be based in the Laboratory of Molecular Neurodegeneration, Kavli Institute for Nanoscience Discovery, South Parks Road, Oxford, OX1 3PT.
 
Informal enquiries may be directed Professor Richard Wade-Martins (richard.wade-martins@dpag.ox.ac.uk).
 
Closing date for applications is midday on Thursday 11 April 2024.
 
Interviews are likely to be held on the week beginning 22 April 2024.

More information: https://bit.ly/3wWbihU

 
Research Assistant neuronal cell biologist: “Biomarkers of lysosomal dysfunction in Parkinson’s disease”
Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin, South Parks Road, Oxford, OX1 3PT
Full-time, Fixed-term for 2 years
 
Applications are invited for a Research Assistant neuronal cell biologist to work on a project to discover novel biomarkers of lysosomal dysfunction in Parkinson’s disease. The project, funded by the Michael J Fox Foundation and in collaboration with EndLyz, a new company within the Dementia Discovery Fund (DDF) portfolio, represents an exciting opportunity to undertake translation work at the interface between academic research and pharmaceutical target and drug discovery in an exceptional setting. This work will develop novel biomarkers to better understand lysosomal dysfunction in Parkinson’s by working with induced pluripotent stem cell (iPSC)-derived dopamine neurons generated from Parkinson’s patients.
 
Duties will include undertaking laboratory experiments; interpretation of data; imaging analysis; generation and study of iPSC-derived neurons and cell lines; preparation of data for publication; study biomarker read-outs of endolysosomal dysfunction in cellular models of Parkinson’s; contribute to wider project planning and determine the most appropriate methodologies to test hypotheses. You will have excellent practical experience of working with induced pluripotent stem cell cultures and good knowledge of cellular models of neurodegenerative disease. The ability to innovate, trouble-shoot technical problems, be meticulous in practical work and in record keeping is essential.
 
Applicants must hold, or be near completion of, a BSc/MSc in a relevant area of research and have experience in cellular neuroscience or molecular cell biology relevant to analysis of neuronal phenotypes.
 
The post is available for 24 months to start on January 1st 2024. The post will be based in the Kavli Institute for Nanoscience Discovery, South Parks Road, Oxford, OX1 3PT
 
Informal enquiries may be directed Professor Richard Wade-Martins (richard.wade-martins@dpag.ox.ac.uk).
 
Closing date for applications is midday on Thursday 11 April 2024.
 
Interviews are likely to be held on the week beginning 22 April 2024.
More information: https://bit.ly/43lrgOO


 To discuss research opportunities with OPDC email opdc.administrator@dpag.ox.ac.uk.