OPDC Vacancies
The Oxford Parkinson's Disease Centre offers attractive opportunities to work with leading researchers in advancing the understanding of Parkinson's.
| Postdoctoral Research Scientist | |||
| Department of Physiology, Anatomy and Genetics, Kavli Institute for Nanoscience Discovery, Parks Road, Oxford, OX1 3QU | |||
Full-time, Fixed term until 03 July 2027 Applications are invited for a Post-Doctoral neuronal cell biologist to work on a project to target calcium channels in Parkinson’s disease. The project, funded by the Michael J Fox Foundation and in collaboration with Lario Therapeutics, represents an exciting opportunity to undertake translation work at the interface between academic research and pharmaceutical target and drug discovery in an exceptional setting. This work will develop new inhibitors of calcium channels as a neuroprotective strategy to protect vulnerable dopamine neurons in Parkinson’s working with induced pluripotent stem cell (iPSC)-derived dopamine neurons generated from Parkinson’s patients. Duties include growth and differentiation of iPSC lines; leading on design and implementation of experiments and cellular assays in neurobiology (eg: calcium imaging, multi-electrode array (MEA), biochemistry, immunocytochemistry, cell and molecular biology; interpretation of data; preparation of data for publication; contribute ideas for new research projects and develop ideas for generating research income; manage own academic research involving small-scale project management; supervise a Research Assistant on the project; and act as a source of information to other members of the group. You will have excellent knowledge relating to neurodegenerative disease and practical experience in neuronal cell culture and in techniques relevant to molecular and cellular neuroscience. The ability to innovate, trouble-shoot technical problems, be meticulous in practical work and in record keeping is also essential. Applicants must hold, or be near completion of, a PhD/DPhil in a relevant area of research and have experience in cellular neuroscience, and molecular cell biology relevant to analysis of neuronal phenotypes. The post is available immediately until 03 July 2027. The post will be based in the Laboratory of Molecular Neurodegeneration, Kavli Institute for Nanoscience Discovery, South Parks Road, Oxford. Informal enquiries may be directed Professor Richard Wade-Martins (richard.wade-martins@dpag.ox.ac.uk). Closing date for applications is midday on Monday 19 August 2024. Interviews are likely to be held the week beginning 2 September 2024. |
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| Research Assistant: Transgenic models of Parkinson’s disease | |||
| Department of Physiology, Anatomy and Genetics, Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, Parks Road, Oxford, OX1 3PT | |||
Full-time, Fixed-term until 30th April 2027 Applications are invited for a Research Assistant to work on a highly collaborative and interdisciplinary project to develop transgenic rodent models of Parkinson’s disease. The work will support projects seeking to use rodent models of disease to understand the earliest stage of neurodegeneration at a point in which neuronal dysfunction precedes neuronal loss, offering an early therapeutic window for therapy. The post will be based in the Laboratory of Molecular Neurodegeneration in the Department of Physiology, Anatomy and Genetics, and is supported by the Wellcome Trust and an international consortium funded by an Aligning Science Across Parkinson’s (ASAP) grant. Duties include colony management, breeding and maintenance of lines of transgenic rodents; collection of brain tissue for gene expression analysis; general laboratory management, preparation of data for publication; contributions to wider project planning and determine the most appropriate methodologies to test hypotheses. You will have a good working knowledge of molecular and cellular biology, excellent practical experience of working with animal models and an interest in pre-clinical in vivo models of neurological disease. Previous experience of the management and maintenance of transgenic rodent lines would be an advantage. The ability to innovate, trouble-shoot technical problems, be meticulous in practical work and in record keeping is also essential. Applicants must hold a BSc/MSc in a relevant area of research and will have excellent practical experience of working with animal models. The fixed-term post is available immediately and until 30th April 2027. The post will be based in the Laboratory of Molecular Neurodegeneration, Kavli Institute for Nanoscience Discovery, New Biochemistry, Phase 2, Parks Road, Oxford. Informal enquiries may be directed to Professor Richard Wade-Martins (richard.wade-martins@dpag.ox.ac.uk). Closing date for applications is midday on Wednesday 31st July 2024. Interviews are likely to be held in the week commencing 2 September 2024. |
To discuss research opportunities with OPDC email opdc.administrator@dpag.ox.ac.uk.