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Understanding heart disease using experimentation and computational physiology

The developing fish heart (Mathilda Mommersteeg)

The mission is to innovate and develop avenues of basic research using multi-scale experimental and computational techniques (from molecule to myocardium). The Burdon Sanderson Cardiac Science Centre is uniquely placed in Oxford to do this, because of its onsite linking of experimentation with integrative modelling. The centre is also a key component of Oxford’s BHF funded Centre of Research Excellence.

The challenge is to re-assemble the vast array of experimental data emerging over different spatial and temporal domains. The opportunity is provided by massively enhanced computing power, enhanced visualisation systems, guided by innovative and ground-breaking experimental work.

The aspiration is to exploit the predictive power of integrative biology, to tackle major issues in cardiac medicine (eg arrhythmia, cardiac hypertrophy, heart failure, regenerative medicine and repair).

The key to success is the close interplay between teams of experimentalists and computational biologists that underpin and complement the disease-led programmes of research within Clinical Departments of the Medical Sciences Division. Importantly this theme maps onto ion channels & signalling, developmental biology, genomics and metabolism which all cut across Cardiac Science.



Groups within this theme

The role of calcium as an intracellular second messenger in cells
Ashley Group

The role of calcium as an intracellular second ...

Cellular mechanisms of oxygen and acid sensing in arterial chemoreceptors
Buckler Group

Cellular mechanisms of oxygen and acid sensing in ...

Optimising cardiac stem cell therapy by finding the best conditions for the cells in the lab and in the heart
Carr Group

Optimising cardiac stem cell therapy by finding ...

Diet, exercise and disease
Clarke Group

Diet, exercise and disease

Human physiology: the pulmonary circulation, age, iron, and exercise
Dorrington Group

Human physiology: the pulmonary circulation, age, ...

Role of triacylglycerol-rich lipoproteins in substrate supply and metabolic signalling
Evans Group

Role of triacylglycerol-rich lipoproteins in ...

Cardiac substrate metabolism: it's all about the energy
Heather Group

Cardiac substrate metabolism: it's all about the ...

Local neuromodulators of cardiac autonomic control
Herring Group

Local neuromodulators of cardiac autonomic control

Interplay between Iron and Oxygen Homeostasis in Systems (Patho)physiology
Lakhal-Littleton Group

Interplay between Iron and Oxygen Homeostasis in ...

The aim of our work is to determine the cellular mechanisms underlying the benefits of traditional multi-herbal Chinese medicines.
Ma Group

The aim of our work is to determine the cellular ...

Heart regeneration & development
Mommersteeg Group

Heart regeneration & development

University of Oxford Innovative Systems Biology Project Sponsored by Tsumura
Noble Group

University of Oxford Innovative Systems Biology ...

Intracellular calcium signalling in health and disease
Parekh Group

Intracellular calcium signalling in health and ...

Gene Transfer of Nitric Oxide Synthase into Cardiac Nerves Modulates Neurotransmission
Paterson Group

Gene Transfer of Nitric Oxide Synthase into ...

Human physiology: Effects of hypoxia and exercise on respiratory, cardiovascular and metabolic function
Robbins Group

Human physiology: Effects of hypoxia and exercise ...

Development, maintenance and regeneration of the cardiovascular system
Smart Group

Development, maintenance and regeneration of the ...

Investigating the Genetic and Environmental Causes of Congenital Heart Disease
Sparrow Group

Investigating the Genetic and Environmental ...

Molecular Physiology: signalling by small ions
Swietach Group

Molecular Physiology: signalling by small ions

Development and Application of Cardiac Magnetic Resonance Imaging and Spectroscopy
Tyler Group

Development and Application of Cardiac Magnetic ...

Intracellular H+ ion signalling and control in the heart
Vaughan-Jones Group

Intracellular H+ ion signalling and control in ...

Cyclic Nucleotides signalling
Zaccolo Group

Cyclic Nucleotides signalling