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We are recognised internationally for our pioneering approaches to systems biology and to computational modelling of the heart.

© The developing fish heart (Mathilda Mommersteeg)

Understanding heart disease using experimentation and computational physiology

The mission is to innovate and develop avenues of basic research using multi-scale experimental and computational techniques (from molecule to myocardium). The Burdon Sanderson Cardiac Science Centre is uniquely placed in Oxford to do this, because of its onsite linking of experimentation with integrative modelling. The centre is also a key component of Oxford’s BHF funded Centre of Research Excellence.

The challenge is to re-assemble the vast array of experimental data emerging over different spatial and temporal domains. The opportunity is provided by massively enhanced computing power, enhanced visualisation systems, guided by innovative and ground-breaking experimental work.

The aspiration is to exploit the predictive power of integrative biology, to tackle major issues in cardiac medicine (eg arrhythmia, cardiac hypertrophy, heart failure, regenerative medicine and repair).

The key to success is the close interplay between teams of experimentalists and computational biologists that underpin and complement the disease-led programmes of research within Clinical Departments of the Medical Sciences Division. Importantly this theme maps onto ion channels & signalling, developmental biology, genomics and metabolism which all cut across Cardiac Science.



Groups within this theme

Cellular mechanisms of oxygen and acid sensing in arterial chemoreceptors
Buckler Group

Cellular mechanisms of oxygen and acid sensing in ...

Optimising cardiac stem cell therapy by finding the best conditions for the cells in the lab and in the heart
Carr Group

Optimising cardiac stem cell therapy by finding ...

Ketone metabolism in exercise and disease
Clarke Group

Ketone metabolism in exercise and disease

Regulation of blood and lymphatic vessel development
De Val Group

Regulation of blood and lymphatic vessel ...

Abnormal metabolism in type 2 diabetes, and how this affects the heart
Heather Group

Abnormal metabolism in type 2 diabetes, and how ...

Local neuromodulators of cardiac autonomic control
Herring Group

Local neuromodulators of cardiac autonomic control

Iron Homeostasis- Mechanisms and importance in systems (patho)physiology
Lakhal-Littleton Group

Iron Homeostasis- Mechanisms and importance in ...

The aim of our work is to determine the cellular mechanisms underlying the benefits of traditional multi-herbal Chinese medicines.
Ma Group

The aim of our work is to determine the cellular ...

Heart regeneration & development
Mommersteeg Group

Heart regeneration & development

Intracellular calcium signalling in health and disease
Parekh Group

Intracellular calcium signalling in health and ...

Gene Transfer of Nitric Oxide Synthase into Cardiac Nerves Modulates Neurotransmission
Paterson Group

Gene Transfer of Nitric Oxide Synthase into ...

Human systems physiology: Respiratory, cardiovascular and metabolic function in response to stresses such as exercise and hypoxia
Robbins Group

Human systems physiology: Respiratory, ...

Development, homeostasis and regeneration of the cardiovascular system
Smart Group

Development, homeostasis and regeneration of the ...

Investigating the Genetic and Environmental Causes of Congenital Heart Disease
Sparrow Group

Investigating the Genetic and Environmental ...

Acid handling and signalling in the heart and in cancer
Swietach Group

Acid handling and signalling in the heart and in ...

Development and Application of Cardiac Magnetic Resonance Imaging and Spectroscopy
Tyler Group

Development and Application of Cardiac Magnetic ...

Investigating regulatory mechanisms of cardiac development, repair and regeneration.
Vieira Group

Investigating regulatory mechanisms of cardiac ...

Cyclic Nucleotides signalling
Zaccolo Group

Cyclic Nucleotides signalling

Latest news

A clue to how a memory-enhancing pill might work

Hundreds of dietary supplements have been reported to improve cognitive and emotional function in humans, but few have scientific foundation. A new study from the Waddell group provides fresh insight into how dietary Magnesium supplementation can influence memory performance.

New MRI technique could detect early signs of heart failure in cancer patients following chemotherapy

New research led by Oxford BHF CRE Intermediate Transition Fellow Dr Kerstin Timm shows that a recently developed imaging technique pioneered by the Tyler Group can detect early metabolic changes in the heart caused by a commonly used chemotherapy drug, which is known to increase risk of heart failure in cancer survivors.

Researchers reveal surprising simplicity behind our ability to hear

A computational modelling study from the King Group demonstrates that the way sounds are transformed from the ear to the brain’s auditory cortex may be simpler than expected. These findings not only highlight the value of computational modelling for determining the principles underlying neural processing, but could also be useful for improving treatments for patients with hearing loss.