Monoamine transmission: from mechanisms to movement
The neurotransmitter dopamine in the brain is critical to how we choose our everyday actions, by signaling our motivations and selecting appropriate movements. When dopamine function is disrupted, a range of psychomotor disorders can result that include addiction disorders and Parkinson’s disease.
Our work explores how dopamine function is governed and dysregulated through study of dopamine transmission in real-time.
In a range of parallel and intersecting projects, we are exploring:
- Mechanisms on dopamine axons that govern dopamine output
- Circuits that govern dopamine transmission
- Dopamine signalling dysfunctions in Parkinson’s disease
- How drugs of addiction modify dopamine signals
- How dopamine controls behaviour
Please get in touch if you’d like to find out how to join the lab.
Cragg group Announcements
October - Welcome to new DPhil students Rishi Anand and Stefi Vietti-Michelina
October - Congratulations Gaya Karthik on passing her MSc viva!
March - Congratulations to Dr Mark Condon on passing his DPhil viva!
March 25th-28th- We are very excited to be hosting the 17th Conference of the International Society for Monitoring Molecules in Neuroscience http://2018.monitoringmolecules.org
January - Welcome Stefania Vietti-Michelina!
December - Congratulations to Dr Ben Hunn on passing his DPhil viva!
October - Welcome to new lab members Dr Lauren Burgeno, Gaya Karthik and Ruth Siddorn!
August - The Call for Abstracts for Monitoring Molecules in Neuroscience 2018 in Oxford is now live! Submit by extended deadline of October 16th
June - Welcome to FHS students Rebecca te Water Naude and Jess Larwood!
March 13th - Dopamine Club with Special Lecture by Prof Paul Bolam
February - Call for Symposia Proposals for Monitoring Molecules in Neuroscience 2018 in Oxford is now live! Submit by March 15th 2017.
Belated welcome to Bradley Roberts and Ahmad Hneino!
Cragg Group News
2 October 2020
A new collaborative study from the Oxford Parkinson’s Disease Centre led by Prof Stephanie Cragg and Dr Bradley Roberts has revealed that GABA transporters on astrocytes, the brain's lesser known yet critically important cells, support dopamine release and are sites of early dysfunction in parkinsonism.
4 November 2019
Our Researchers at the Oxford Parkinson’s Disease Centre have shown that cell recycling in Parkinson’s may play a more complex role than previously thought.
20 September 2019
The release of dopamine in the brain plays a key role in determining how we respond when we perceive a potential reward or benefit. But so far little has been understood about the mechanism behind this. A new collaborative paper from Prof Stephanie Cragg's Group and Prof Ed Mann published in Nature Communications has uncovered a dominant regulator of the dynamics of dopamine output.
Dopamine Club is an informal, lab meeting-style forum that brings dopamine researchers together from across the University to exchange and discuss our different perspectives on dopamine.
Dopamine Club was founded in 2014 to bring together dopamine researchers within the University and promote interactions towards the common goal of understanding dopamine function.
Anyone is welcome to attend, organise and participate in Dopamine Club meetings and we'd like it to be as interactive as possible so if you want to be involved please get in touch (firstname.lastname@example.org, or any of the other contributing groups).
Meetings are held termly, usually on Monday of 8th week, in DPAG. Meetings are chaired by different labs on a rotating basis.
Book Chapters and Other Articles
Handbook of Basal Ganglia Structure and Function, 2nd Edition
Compendium of in Vivo Monitoring in Real-Time Molecular Neuroscience: Fundamentals and Applications v. 1
GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model.
Roberts BM. et al, (2020), Nat Commun, 11
CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease.
Bengoa-Vergniory N. et al, (2020), Nat Commun, 11
Diabetes Causes Dysfunctional Dopamine Neurotransmission Favoring Nigrostriatal Degeneration in Mice.
Pérez-Taboada I. et al, (2020), Mov Disord
L-type calcium channel contribution to striatal dopamine release is governed by calbindin-D28K, the dopamine transporter, D2-receptors, α2δ-subunits and sex differences
Brimblecombe KR. et al, (2020)