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Cragg Group

Monoamine transmission: from modulation to movement

Dopamine neurons and extended dendrites in substantia nigra
Dopamine neurons and extended dendrites in substantia nigra

The neurotransmitter dopamine in the brain is critical to how we choose our everyday actions, by signaling our motivations and selecting appropriate movements. When dopamine function is disrupted, a range of psychomotor disorders can result that include addiction disorders and Parkinson’s disease.

Our work explores how dopamine function is governed and dysregulated through study of dopamine transmission in real-time.

In a range of parallel and intersecting projects, we are exploring:

  • Mechanisms on dopamine axons that govern dopamine output
  • Circuits that govern dopamine transmission
  • Dopamine signalling dysfunctions in Parkinson’s disease
  • How drugs of addiction modify dopamine signals
  • How dopamine controls behaviour

Please get in touch if you’d like to find out how to join the lab.

 

Our team

Cragg group Announcements

2018 News

October - Welcome to new DPhil students Rishi Anand and Stefi Vietti-Michelina

October - Congratulations Gaya Karthik on passing her MSc viva!

March - Congratulations to Dr Mark Condon on passing his DPhil viva!

March 25th-28th- We are very excited to be hosting the 17th Conference of the International Society for Monitoring Molecules in Neuroscience http://2018.monitoringmolecules.org

January - Welcome Stefania Vietti-Michelina!

2017 News

December - Congratulations to Dr Ben Hunn on passing his DPhil viva!

October - Welcome to new lab members Dr Lauren Burgeno, Gaya Karthik and Ruth Siddorn!

August - The Call for Abstracts for Monitoring Molecules in Neuroscience 2018 in Oxford is now live! Submit by extended deadline of October 16th
http://2018.monitoringmolecules.org/submit-an-abstract/

June - Welcome to FHS students Rebecca te Water Naude and Jess Larwood!

March 13th  - Dopamine Club with Special Lecture by Prof Paul Bolam

February - Call for Symposia Proposals for Monitoring Molecules in Neuroscience 2018 in Oxford is now live! Submit by March 15th 2017.
http://2018.monitoringmolecules.org/propose-a-symposium/

Belated welcome to Bradley Roberts and Ahmad Hneino!

Dopamine Club

  • Welcome to the Dopamine Club!

    Dopamine Club is an informal, lab meeting-style forum that brings dopamine researchers together from across the University to exchange and discuss our different perspectives on dopamine.

  • About us

    Dopamine Club was founded in 2014 to bring together dopamine researchers within the University and promote interactions towards the common goal of understanding dopamine function.

  • Core contributors

    Anyone is welcome to attend, organise and participate in Dopamine Club meetings and we'd like it to be as interactive as possible so if you want to be involved please get in touch (stephanie.cragg@dpag.ox.ac.uk, or any of the other contributing groups).

  • Meeting format

    Meetings are held termly, usually on Monday of 8th week, in DPAG. Meetings are chaired by different labs on a rotating basis.

  • Forthcoming meetings

Latest publications

Video Abstract

Pauses in Cholinergic Interneuron Activity Are Driven by Excitatory Input and Delayed Rectification With Dopamine Modulation

Related research themes

We host a number of internationally recognised neuroscience groups, with expertise in a wide range of experimental and computational methods.
Neuroscience