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Monoamine transmission: mechanisms, microcircuits and modulation

Dopamine neurons and dendrites in SN and VTA

The neurotransmitter dopamine in the brain is critical to how we choose our everyday actions, by signaling our motivations and selecting appropriate movements. When dopamine function is disrupted, a range of psychomotor disorders can result that include addiction disorders and Parkinson’s disease. Also, dopamine operates in balance with a range of other neuromodulators such as acetylcholine, whose interactions remain incompletely understood.

Our work explores how dopamine function is governed and dysregulated and interacts with the complex neuromodulator landscape in real-time.

In a range of intersecting and collaborative projects, we are exploring:

  • How dopamine axons govern dopamine output
  • Neuromodulators and circuits that govern a balance of dopamine and acetylcholine signalling
  • Roles for neuronal and non-neuronal cell types
  • Dysregulation in dopamine and related neuromodulators in Parkinson’s disease
  • How drugs of addiction modify dopamine signals and regulatory circuits
  • Circuits that control behaviour

Please get in touch if you’d like to join the lab, and see current recruitment opportunities below.

 

Cragg Group Announcements

**We are recruiting!**

Interested in joining us? We are currently advertising for a Postdoctoral Research Scientist to join a Wellcome Trust-funded project. Advert is live here, closing date is 1st July 2024. 

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May 2024 - Steph takes up the Presidency of the International Society for Monitoring Molecules in Neuroscience, plan to join us for Amsterdam 2026!

May 2024 - Congratulations Qinbo Qiao on being selected for an invited Podium Presentation at the International Meeting for Monitoring Molecules in Neuroscience at UNC, North Carolina

April 2024 - Welcome to our undergrad research student Sayon Choudhuri!

April 2024 - Congratulations Lucille Duquenoy on the Award of a Goodger and Shorstein Scholarship for 2024-2025

April 2024 - Congratulations to Kat Todd for best flash talk and Aishwarya Vedula for best poster prize at the UKDRI-ASAP meeting in London!

November 2023 - We welcome visiting Marie Skłodowska-Curie Fellow Alice Petty, and research assistant Wenhui Wu

September 2023 - Congratulations to Shinil Raina and Emanuel Lopes for winning 1st and 2nd Poster Prizes at the meeting for Aligning Science Across Parkinson's in London

January 2023 - Congratulations Katherine Brimblecombe for a DPAG Prize for Public Engagement

January 2023 - We welcome new lab members postdocs Simon Bossi, Susanne Szydlowski and Kathryn Todd!

November 2022 - Congratulations Jess Livesey for Runner up prize at second-year DPhil student poster day!

September 2022 - We welcome new lab members Qinbo Qiao, Ana Sousa and Elliot Yates!

September 2022 - We welcome to Oxford all of ASAP Team Cragg for our first annual in-person conference!

July 2022 - Congratulations Stefi Vietti-Michelina for a successful DPhil viva!

May 2022 - We are delighted to begin our new Wellcome Trust-funded collaboration with Profs Richard Wade-Martins, Peter Magill, Birgit Liss and Josef Kittler

February 2022 - We welcome our new ASAP Project Manager Claudia Mendes!

January 2022 - We welcome new lab member Ross McLeod!

November 2021 - We are delighted to begin our new major international collaborative research project supported by Aligning Science Across Parkinson's (ASAP) with Mark Howe (Boston University), Dinos Meletis (Karolinska Institutet), Richard Wade-Martins (Oxford) and Peter Magill (Oxford)

Please read our pledge to support inclusivity, diversity and equality here.

Our team

Cragg Group News

Inaugural winners of the DPAG Prize for Public Engagement with Research announced

Congratulations are in order for the winners Katherine Brimblecombe and Anna Kordala, and also to Jéssica Luiz and Andia Redpath who were highly commended for their outreach and public engagement work.

Winners of the DPAG Student Poster Day 2022 announced

"A Year of Progress" was held in the Sherrington Library on Wednesday 9 November 2022.

Oxford Parkinson’s Disease Centre awarded £3.8 million to reveal the role of calcium in Parkinson’s

A collaborative research team led by the Oxford Parkinson’s Disease Centre (OPDC) has been awarded a £3.8 million Wellcome Trust Collaborative Award to study the function of calcium in dopamine neurons, and how this is plays a role in Parkinson’s. Their research will help explain how and why dopamine neurons are vulnerable in the disease and look at how they may be preserved.

Dopamine Club

Welcome to the Dopamine Club!

Dopamine Club is an informal, lab meeting-style forum that brings dopamine researchers together from across the University to exchange and discuss our different perspectives on dopamine.

About us

Dopamine Club was founded in 2014 to bring together dopamine researchers within the University and promote interactions towards the common goal of understanding dopamine function.

Core contributors

Anyone is welcome to attend, organise and participate in Dopamine Club meetings and we'd like it to be as interactive as possible so if you want to be involved please get in touch (stephanie.cragg@dpag.ox.ac.uk, or any of the other contributing groups).

Meeting format

Meetings are held termly, usually on Monday of 8th week, in DPAG. Meetings are chaired by different labs on a rotating basis.

Related research themes

We host a number of internationally recognised neuroscience groups, with expertise in a wide range of experimental and computational methods.
Neuroscience

We host a number of internationally recognised ...