Monoamine transmission: from motivation to movement
The neurotransmitter dopamine in the brain is critical to how we choose our everyday actions, by signaling our motivations and selecting appropriate movements. When dopamine function is disrupted, a range of psychomotor disorders can result that include addiction disorders and Parkinson’s disease.
Our work explores how dopamine function is governed and dysfunction manifests, through study of how dopamine ‘synapses’ function in real-time.
In a range of parallel and intersecting projects, we are exploring:
- Mechanisms in dopamine axons that govern whether action potentials in dopamine neurons are relayed by dopamine to its targets.
- Circuits that drive dopamine transmission
- How drugs of addiction modify dopamine signals
- Deficits in dopamine signaling that precede pathology in Parkinson’s disease
- Development of novel optogenetic tools to study dopamine neurons
- How dopamine controls behaviour
Please get in touch if you’d like to find out how to join the lab.
*Cragg group news*
October 17th 2015 - Join us at SFN2015 Chicago for Minisymposium on the Dorsal Striatum! (http://www.sfn.org/annual-meeting/neuroscience-2015/sessions-and-events/scientific-program/minisymposia)
October 2015 - Welcome to new student Emanuel Lopes and intern Rahel Kaestli
October 2015 - SJC speaking at "Basal Ganglia in Health and Disease" at the Institut du Fer a Moulin, Paris
at inaugural GRC Parkinson's Disease
July 2015 - SJC speaking at inaugural GRC Parkinson's Disease
June 2015 - SJC speaking at Symposium 'Ion Channels to Behaviour' Copenhagen to honour Jorn Hounsgaard
April 2015 - Welcome to MSc student Alex Pike
April 2015 - Katie Jennings talks at Edinburgh International Science Festival!
April 14th 2015 - Join us at Symposium 'Cholinergic Neuromodulation in the CNS: From Single Cells to Networks' at the BNA 2015 Festival of Neuroscience in Edinburgh: S Cragg, M Shah, M Hasselmo, A Thiele (http://www.bna.org.uk/festival2015)
March 2015 - Mark Walton and Katie Jennings discuss promises and pitfalls of FCV at Dopamine Club
Feb 2015 - Book chapter published - Kosillo P, Brimblecombe K, Threlfell S, Cragg SJ. (2015) Coupling optogenetics with voltammetry. In: Advances in Real-time Molecular Neuroscience (Eds A. Michael, G. Wilson), World Scientific Publishing Co.
February 2015 - Welcome to students Mireia Coll Tane, Corentin Gaillard and MSc student Rebecca Nutbrown
October 2014 - Welcome to new graduate student Mark Condon
September 2014 - International Innovation publish article about some of our work : http://www.internationalinnovation.com/hope-for-dopamine-disorders/
August 2014 - Katherine Brimblecombe gives a talk on her work at 'Monitoring Molecules in Neuroscience:15th International Conference' at UCLA, USA (http://www.monitoringmolecules.org/2014/)
July 2014 - Katie Jennings gives a talk in symposium 'Fast measurements of serotonin in brain', at 11th Congress of the International Society for Serotonin Research, South Africa (http://www.serotoninclub.org/)
July 2014 - Symposium 'Cholinergic Neuromodulation in the CNS: From Single Cells to Networks' accepted for the BNA 2015 Festival of Neuroscience in Edinburgh, M Shah, D Brown, S Cragg, M Hasselmo, A Thiele (http://www.bna.org.uk/festival2015)
June 2014 - Congratulations to Polina Kosillo - Winner of Sherrington Prize for 3rd year DPhil talks
June 2014 - Polina Kosillo awarded postdoctoral position in lab of Helen Bateup, UC Berkeley USA, to start end of 2014. Well done Polina!
- Article preview for Brimblecombe et al 2015 J Neurosci by Esch (2015) Substance P Exerts Compartment-Specific Effects on Striatal Dopamine Release J Neurosci 35:i http://www.jneurosci.org/content/35/24/i.short
- Compendium of in Vivo Monitoring in Real-Time Molecular Neuroscience: Fundamentals and Applications v. 1 (http://www.worldscientific.com/worldscibooks/10.1142/9295#t=aboutBook)
- Article preview for Threlfell et al 2012 Neuron by Surmeier and Graybiel - "A feud that wasn't: acetylcholine evokes dopamine release in the striatum" - see Neuron http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461267/
- Parkinson's UK news - http://www.parkinsons.org.uk/news/12-july-2012/oxford-researchers-discover-potential-new-treatment-avenue-parkinsons
Dopamine Club is an informal, lab meeting-style forum that brings dopamine researchers together from across the University to exchange and discuss our different perspectives on dopamine.
Dopamine Club was founded in 2014 to bring together dopamine researchers within the University and promote interactions towards the common goal of understanding dopamine function.
Anyone is welcome to attend, organise and participate in Dopamine Club meetings and we'd like it to be as interactive as possible so if you want to be involved please get in touch (firstname.lastname@example.org, or any of the other contributing groups).
Meetings are held termly, usually on Monday of 8th week, in DPAG. Meetings are chaired by different labs on a rotating basis.