Monoamine transmission: from modulation to movement
The neurotransmitter dopamine in the brain is critical to how we choose our everyday actions, by signaling our motivations and selecting appropriate movements. When dopamine function is disrupted, a range of psychomotor disorders can result that include addiction disorders and Parkinson’s disease.
Our work explores how dopamine function is governed and dysregulated through study of dopamine transmission in real-time.
In a range of parallel and intersecting projects, we are exploring:
- Mechanisms on dopamine axons that govern dopamine output
- Circuits that govern dopamine transmission
- Dopamine signalling dysfunctions in Parkinson’s disease
- How drugs of addiction modify dopamine signals
- How dopamine controls behaviour
Please get in touch if you’d like to find out how to join the lab.
Cragg group Announcements
October - Welcome to new DPhil students Rishi Anand and Stefi Vietti-Michelina
October - Congratulations Gaya Karthik on passing her MSc viva!
March - Congratulations to Dr Mark Condon on passing his DPhil viva!
March 25th-28th- We are very excited to be hosting the 17th Conference of the International Society for Monitoring Molecules in Neuroscience http://2018.monitoringmolecules.org
January - Welcome Stefania Vietti-Michelina!
December - Congratulations to Dr Ben Hunn on passing his DPhil viva!
October - Welcome to new lab members Dr Lauren Burgeno, Gaya Karthik and Ruth Siddorn!
August - The Call for Abstracts for Monitoring Molecules in Neuroscience 2018 in Oxford is now live! Submit by extended deadline of October 16th
June - Welcome to FHS students Rebecca te Water Naude and Jess Larwood!
March 13th - Dopamine Club with Special Lecture by Prof Paul Bolam
February - Call for Symposia Proposals for Monitoring Molecules in Neuroscience 2018 in Oxford is now live! Submit by March 15th 2017.
Belated welcome to Bradley Roberts and Ahmad Hneino!
Cragg Group News
Dopamine Club is an informal, lab meeting-style forum that brings dopamine researchers together from across the University to exchange and discuss our different perspectives on dopamine.
Dopamine Club was founded in 2014 to bring together dopamine researchers within the University and promote interactions towards the common goal of understanding dopamine function.
Anyone is welcome to attend, organise and participate in Dopamine Club meetings and we'd like it to be as interactive as possible so if you want to be involved please get in touch (email@example.com, or any of the other contributing groups).
Meetings are held termly, usually on Monday of 8th week, in DPAG. Meetings are chaired by different labs on a rotating basis.
Book Chapters and Other Articles
Handbook of Basal Ganglia Structure and Function, 2nd Edition
Compendium of in Vivo Monitoring in Real-Time Molecular Neuroscience: Fundamentals and Applications v. 1
Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter
CRAGG S. et al, (2019), Nature Communications
Calbindin-D28K limits dopamine release in ventral but not dorsal striatum by regulating Ca2+ availability and dopamine transporter function
Brimblecombe KR. et al, (2019), ACS Chemical Neuroscience
TrkB-dependent disinhibition of the nucleus accumbens is enhanced by ethanol
Patton MH. et al, (2019), Neuropsychopharmacology, 44, 1114 - 1122
Selective vulnerability in α-synucleinopathies.
Alegre-Abarrategui J. et al, (2019), Acta Neuropathol