Monoamine transmission: mechanisms, microcircuits and movement
The neurotransmitter dopamine in the brain is critical to how we choose our everyday actions, by signaling our motivations and selecting appropriate movements. When dopamine function is disrupted, a range of psychomotor disorders can result that include addiction disorders and Parkinson’s disease.
Our work explores how dopamine function is governed and dysregulated through study of dopamine transmission in real-time.
In a range of parallel and intersecting projects, we are exploring:
- Mechanisms on dopamine axons that govern dopamine output
- Circuits that govern dopamine transmission
- Dysregulation in dopamine and related neuromodulators in Parkinson’s disease
- How drugs of addiction modify dopamine signals
- Circuits that control behaviour
Please get in touch if you’d like to join the lab, and see current recruitment opportunities below.
Cragg Group Announcements
**We are recruiting!**
Interested in joining us? Please stay tuned for our imminent advert for a Research Assistant to join our international ASAP-funded collaboration.
November 2023 - We welcome visiting Marie Skłodowska-Curie Fellow Alice Petty, and Wenhui Wu
January 2023 - We welcome new lab members Simon Bossi, Susanne Szydlowski and Kathryn Todd!
September 2022 - We welcome new lab members Qinbo Qiao, Ana Sousa and Elliot Yates!
September 2022 - We welcome to Oxford all of ASAP Team Cragg for our first annual in-person conference!
May 2022 - We are delighted to begin our new Wellcome Trust-funded collaboration with Profs Richard Wade-Martins, Peter Magill, Birgit Liss and Josef Kittler
February 2022 - We welcome our new ASAP Project Manager Claudia Mendes!
January 2022 - We welcome new lab member Ross McLeod!
November 2021 - We are delighted to begin our new major international research project supported by Aligning Science Across Parkinson's (ASAP) with Mark Howe (Boston University), Dinos Meletis (Karolinska Institutet), Richard Wade-Martins (Oxford) and Peter Magill (Oxford)
Please read our pledge to support inclusivity, diversity and equality here.
Cragg Group News
11 January 2023
Congratulations are in order for the winners Katherine Brimblecombe and Anna Kordala, and also to Jéssica Luiz and Andia Redpath who were highly commended for their outreach and public engagement work.
11 November 2022
"A Year of Progress" was held in the Sherrington Library on Wednesday 9 November 2022.
29 April 2022
A collaborative research team led by the Oxford Parkinson’s Disease Centre (OPDC) has been awarded a £3.8 million Wellcome Trust Collaborative Award to study the function of calcium in dopamine neurons, and how this is plays a role in Parkinson’s. Their research will help explain how and why dopamine neurons are vulnerable in the disease and look at how they may be preserved.
Dopamine Club is an informal, lab meeting-style forum that brings dopamine researchers together from across the University to exchange and discuss our different perspectives on dopamine.
Dopamine Club was founded in 2014 to bring together dopamine researchers within the University and promote interactions towards the common goal of understanding dopamine function.
Anyone is welcome to attend, organise and participate in Dopamine Club meetings and we'd like it to be as interactive as possible so if you want to be involved please get in touch (firstname.lastname@example.org, or any of the other contributing groups).
Meetings are held termly, usually on Monday of 8th week, in DPAG. Meetings are chaired by different labs on a rotating basis.
Book Chapters and Other Articles
|Handbook of Basal Ganglia Structure and Function, 2nd Edition|
|Compendium of in Vivo Monitoring in Real-Time Molecular Neuroscience: Fundamentals and Applications v. 1|
Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson's.
Brimblecombe KR. et al, (2023), Eur J Neurosci
Axo-glial interactions between midbrain dopamine neurons and oligodendrocyte lineage cells in the anterior corpus callosum.
Caldwell M. et al, (2023), Brain Struct Funct, 228, 1993 - 2006
Discovery of CVN417, a Novel Brain-Penetrant α6-Containing Nicotinic Receptor Antagonist for the Modulation of Motor Dysfunction.
Christie LA. et al, (2023), J Med Chem
Coincidence of cholinergic pauses, dopaminergic activation and depolarisation of spiny projection neurons drives synaptic plasticity in the striatum
Reynolds JNJ. et al, (2022), Nature Communications, 13