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OPDC Publications

Mitochondrial Dysfunction and Mitophagy in Parkinson's Disease

Cover image of Trends in Biochemical Sciences Volume 46, Number 4, April 2021

See the full issue

2023

Theme 1 Clinical

Author Correction: Accurate long-read sequencing identified GBA1 as major risk factor in the Luxembourgish Parkinson's study.
Journal article

Pachchek S. et al, (2023), NPJ Parkinsons Dis, 9
Accurate long-read sequencing identified GBA1 as major risk factor in the Luxembourgish Parkinson’s study
Journal article

Pachchek S. et al, (2023), npj Parkinson's Disease, 9
Altered Impulsivity Across Drug-Naïve Parkinsonism, Isolated Rapid Eye Movement Sleep Behavior Disorder, and Their High-Risk Relatives.
Journal article

Zhou L. et al, (2023), Ann Neurol
Investigating gait-responsive somatosensory cueing from a wearable device to improve walking in Parkinson's disease.
Journal article

Li D. et al, (2023), Biomed Eng Online, 22
A programme evaluation of 'First Steps': A peer-conceived, developed and led self-management intervention for people after a Parkinson's diagnosis.
Journal article

Collett J. et al, (2023), Clin Rehabil
Investigation of the genetic aetiology of Lewy body diseases with and without dementia.
Journal article

Wu L. et al, (2023), medRxiv
Genome-wide Analysis of Motor Progression in Parkinson Disease.
Journal article

Martínez Carrasco A. et al, (2023), Neurol Genet, 9
Genetic meta-analysis of levodopa induced dyskinesia in Parkinson's disease.
Journal article

Martinez-Carrasco A. et al, (2023), NPJ Parkinsons Dis, 9
Progression of clinical markers in prodromal Parkinson's disease and dementia with Lewy bodies: a multicentre study.
Journal article

Joza S. et al, (2023), Brain, 146, 3258 - 3272
Progression of atypical parkinsonian syndromes: PROSPECT-M-UK study implications for clinical trials.
Journal article

Street D. et al, (2023), Brain, 146, 3232 - 3242
Prodromal dementia with Lewy bodies in REM sleep behavior disorder: A multicenter study.
Journal article

Joza S. et al, (2023), Alzheimers Dement
HLA in isolated REM sleep behavior disorder and Lewy body dementia.
Journal article

Yu E. et al, (2023), Ann Clin Transl Neurol
Towards a multi-arm multi-stage platform trial of disease modifying approaches in Parkinson's disease.
Journal article

Foltynie T. et al, (2023), Brain, 146, 2717 - 2722
NPC1 variants are not associated with Parkinson's disease, REM-sleep behavior disorder or dementia with Lewy bodies in European cohorts.
Journal article

Somerville EN. et al, (2023), Neurobiol Aging, 127, 94 - 98
Reward insensitivity is associated with dopaminergic deficit in rapid eye movement sleep behaviour disorder.
Journal article

Barber TR. et al, (2023), Brain, 146, 2502 - 2511
Co-Existent Probable RBD and PD: Disease Progression, Medication Response, and Clinical Trial Implications
Journal article

Zou H. et al, (2023), Movement Disorders Clinical Practice
Subthalamic nucleus shows opposite functional connectivity pattern in Huntington's and Parkinson's disease.
Journal article

Evangelisti S. et al, (2023), Brain Commun, 5
Embedding Patient Input in Outcome Measures for Long-Term Disease-Modifying Parkinson Disease Trials
Journal article

Gonzalez-Robles C. et al, (2023), Movement Disorders
Identification of a possible proteomic biomarker in Parkinson's disease: discovery and replication in blood, brain and cerebrospinal fluid.
Journal article

Winchester L. et al, (2023), Brain Commun, 5
Outcome Measures for Disease-Modifying Trials in Parkinson's Disease: Consensus Paper by the EJS ACT-PD Multi-Arm Multi-Stage Trial Initiative.
Journal article

Gonzalez-Robles C. et al, (2023), J Parkinsons Dis, 13, 1013 - 1035
B lymphocyte responses in Parkinson's disease and their possible significance in disease progression.
Journal article

Scott KM. et al, (2023), Brain Commun, 5

Theme 2 Cellular

Correction: Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons.
Journal article

Hasan S. et al, (2023), Mol Neurodegener, 18
Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons.
Journal article

Hasan S. et al, (2023), Mol Neurodegener, 18
C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9.
Journal article

Vahsen BF. et al, (2023), Nat Commun, 14
Patient-derived iPSC models of Friedreich ataxia: a new frontier for understanding disease mechanisms and therapeutic application
Journal article

Maheshwari S. et al, (2023), Translational Neurodegeneration, 12
Mitochondrial dysfunction and mitophagy defects in LRRK2-R1441C Parkinson's disease models.
Journal article

Williamson MG. et al, (2023), Hum Mol Genet, 32, 2808 - 2821
Impaired dopamine release in Parkinson's disease.
Journal article

Cramb KML. et al, (2023), Brain, 146, 3117 - 3132
Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson's iPSC-dopamine neurons.
Journal article

Beccano-Kelly DA. et al, (2023), iScience, 26
Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson's disease GBA-N370S dopamine neurons.
Journal article

Bogetofte H. et al, (2023), Cell Rep, 42
Early striatal hyperexcitability in anin vitrohuman striatal microcircuit model carrying the Parkinson’sGBA-N370Smutation
Preprint

Do QB. et al, (2023)
Multi-modal Proteomic Characterization of Lysosomal Function and Proteostasis in Progranulin-Deficient Neurons.
Journal article

Hasan S. et al, (2023), bioRxiv
Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function.
Journal article

Carling PJ. et al, (2023), Autophagy, 19, 692 - 705
Identification of a possible proteomic biomarker in Parkinson's disease: discovery and replication in blood, brain and cerebrospinal fluid.
Journal article

Winchester L. et al, (2023), Brain Commun, 5
Multi-modal Proteomic Characterization of Lysosomal Function and Proteostasis in Progranulin-Deficient Neurons
Conference paper

Hasan S. et al, (2023), JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 82, 541 - 541

Theme 3 Models

Axo-glial interactions between midbrain dopamine neurons and oligodendrocyte lineage cells in the anterior corpus callosum.
Journal article

Caldwell M. et al, (2023), Brain Struct Funct, 228, 1993 - 2006
Discovery of CVN417, a Novel Brain-Penetrant α6-Containing Nicotinic Receptor Antagonist for the Modulation of Motor Dysfunction.
Journal article

Christie LA. et al, (2023), J Med Chem
A selective projection from the subthalamic nucleus to parvalbumin-expressing interneurons of the striatum.
Journal article

Kondabolu K. et al, (2023), eNeuro
The aperiodic exponent of subthalamic field potentials reflects excitation/inhibition balance in Parkinsonism.
Journal article

Wiest C. et al, (2023), Elife, 12

2022

Theme 1 Clinical

Neurofilament light levels predict clinical progression and death in multiple system atrophy.
Journal article

Chelban V. et al, (2022), Brain, 145, 4398 - 4408
Genome-wide association study of REM sleep behavior disorder identifies polygenic risk and brain expression effects.
Journal article

Krohn L. et al, (2022), Nat Commun, 13
Universal clinical Parkinson's disease axes identify a major influence of neuroinflammation.
Journal article

Sandor C. et al, (2022), Genome Med, 14
Association between the LRP1B and APOE loci in the development of Parkinson's disease dementia.
Journal article

Real R. et al, (2022), Brain
Publisher Correction: Age at onset as stratifier in idiopathic Parkinson's disease - effect of ageing and polygenic risk score on clinical phenotypes.
Journal article

Pavelka L. et al, (2022), NPJ Parkinsons Dis, 8
Age at onset as stratifier in idiopathic Parkinson's disease - effect of ageing and polygenic risk score on clinical phenotypes.
Journal article

Pavelka L. et al, (2022), NPJ Parkinsons Dis, 8
Exploration of whether socioeconomic factors affect the results of priority setting partnerships: updating the top 10 research priorities for the management of Parkinson's in an international setting.
Journal article

Bowring F. et al, (2022), BMJ Open, 12
Genetics of validated Parkinson's disease subtypes in the Oxford Discovery and Tracking Parkinson's cohorts.
Journal article

Lawton M. et al, (2022), J Neurol Neurosurg Psychiatry
A composite clinical motor score as a comprehensive and sensitive outcome measure for Parkinson's disease.
Journal article

Lo C. et al, (2022), J Neurol Neurosurg Psychiatry, 93, 617 - 624
Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies.
Journal article

Poggiolini I. et al, (2022), Brain, 145, 584 - 595
Dietary Patterns and Nonmotor Symptoms in Parkinson's Disease: A Cross-Sectional Analysis.
Journal article

Lawrie S. et al, (2022), J Am Nutr Assoc, 1 - 10
Author Correction: Mapping brain structural differences and neuroreceptor correlates in Parkinson's disease visual hallucinations.
Journal article

Vignando M. et al, (2022), Nat Commun, 13
Quantifying activities of daily living impairment in Parkinson's disease using the Functional Activities Questionnaire.
Journal article

Becker S. et al, (2022), Neurol Sci, 43, 1047 - 1054
Mapping brain structural differences and neuroreceptor correlates in Parkinson's disease visual hallucinations.
Journal article

Vignando M. et al, (2022), Nat Commun, 13
Rare PSAP Variants and Possible Interaction with GBA in REM Sleep Behavior Disorder.
Journal article

Sosero YL. et al, (2022), J Parkinsons Dis, 12, 333 - 340
Automated Movement Detection with Dirichlet Process Mixture Models and Electromyography
Conference paper

Cooray N. et al, (2022), 2022 25th International Conference on Information Fusion, FUSION 2022

Theme 2 Cellular

Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement.
Journal article

Fdez E. et al, (2022), iScience, 25
Hyperexcitability in young iPSC-derived C9ORF72 mutant motor neurons is associated with increased intracellular calcium release.
Journal article

Burley S. et al, (2022), Sci Rep, 12
Neurons derived from individual early Alzheimer's disease patients reflect their clinical vulnerability.
Journal article

Ng B. et al, (2022), Brain Commun, 4

Theme 3 Models

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2.
Journal article

Kosillo P. et al, (2022), Elife, 11
Distributional coding of associative learning within projection-defined populations of midbrain dopamine neurons
Preprint

Avvisati R. et al, (2022)
Dopamine Release in Nucleus Accumbens Is under Tonic Inhibition by Adenosine A1 Receptors Regulated by Astrocytic ENT1 and Dysregulated by Ethanol.
Journal article

Roberts BM. et al, (2022), J Neurosci, 42, 1738 - 1751
Stimulating at the right time to recover network states in a model of the cortico-basal ganglia-thalamic circuit.
Journal article

West TO. et al, (2022), PLoS Comput Biol, 18

2021

Theme 1 Clinical

Longitudinal Changes in Parkinson's Disease Symptoms with and Without Rapid Eye Movement Sleep Behavior Disorder: The Oxford Discovery Cohort Study.
Journal article

Liu Y. et al, (2021), Mov Disord, 36, 2821 - 2832
Altered network stability in progressive supranuclear palsy.
Journal article

Whiteside DJ. et al, (2021), Neurobiol Aging, 107, 109 - 117
Validation of α-Synuclein in L1CAM-Immunocaptured Exosomes as a Biomarker for the Stratification of Parkinsonian Syndromes.
Journal article

Jiang C. et al, (2021), Mov Disord, 36, 2663 - 2669
Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder.
Journal article

Miglis MG. et al, (2021), Lancet Neurol, 20, 671 - 684
Non-motor predictors of 36-month quality of life after subthalamic stimulation in Parkinson disease.
Journal article

Jost ST. et al, (2021), NPJ Parkinsons Dis, 7
Exenatide once weekly over 2 years as a potential disease-modifying treatment for Parkinson's disease: protocol for a multicentre, randomised, double blind, parallel group, placebo controlled, phase 3 trial: The 'Exenatide-PD3' study.
Journal article

Vijiaratnam N. et al, (2021), BMJ Open, 11
Olfactory Testing in Parkinson Disease and REM Behavior Disorder: A Machine Learning Approach.
Journal article

Lo C. et al, (2021), Neurology, 96, e2016 - e2027
Proof of concept: Screening for REM sleep behaviour disorder with a minimal set of sensors.
Journal article

Cooray N. et al, (2021), Clin Neurophysiol, 132, 904 - 913
Temporal orienting in Parkinson's disease.
Journal article

Zokaei N. et al, (2021), Eur J Neurosci, 53, 2713 - 2725
Novel Associations of BST1 and LAMP3 With REM Sleep Behavior Disorder.
Journal article

Mufti K. et al, (2021), Neurology, 96, e1402 - e1412
Dopaminergic imaging and clinical predictors for phenoconversion of REM sleep behaviour disorder.
Journal article

Arnaldi D. et al, (2021), Brain, 144, 278 - 287
Genome-Wide Association Studies of Cognitive and Motor Progression in Parkinson's Disease.
Journal article

Tan MMX. et al, (2021), Mov Disord, 36, 424 - 433
Comprehensive Analysis of Familial Parkinsonism Genes in Rapid-Eye-Movement Sleep Behavior Disorder.
Journal article

Mufti K. et al, (2021), Mov Disord, 36, 235 - 240
Reduced cortico-muscular beta coupling in Parkinson's disease predicts motor impairment.
Journal article

Zokaei N. et al, (2021), Brain Commun, 3
Network Analysis of the CSF Proteome Characterizes Convergent Pathways of Cellular Dysfunction in ALS.
Journal article

Thompson AG. et al, (2021), Front Neurosci, 15
Orofacial pain in 1916 patients with early or moderate Parkinson disease.
Journal article

O'Neill F. et al, (2021), Pain Rep, 6
Parkinson's Disease Subtypes: Critical Appraisal and Recommendations.
Journal article

Mestre TA. et al, (2021), J Parkinsons Dis, 11, 395 - 404

Theme 2 Cellular

Identification of a novel proteomic Biomarker in Parkinson’s Disease: Discovery and Replication in Blood, brain and CSF
Preprint

Winchester L. et al, (2021)
Erratum: Ryan et al., "REST Protects Dopaminergic Neurons from Mitochondrial and α-Synuclein Oligomer Pathology in an Alpha Synuclein Overexpressing BAC-Transgenic Mouse Model".
Journal article

(2021), J Neurosci, 41
A novel post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson’s diseaseGBA-N370Sdopamine neurons
Preprint

Bogetofte H. et al, (2021)
Identification of bioactive metabolites in human iPSC-derived dopaminergic neurons with PARK2 mutation: Altered mitochondrial and energy metabolism.
Journal article

Okarmus J. et al, (2021), Stem Cell Reports, 16, 1510 - 1526
Gene therapy restores dopamine transporter expression and ameliorates pathology in iPSC and mouse models of infantile parkinsonism.
Journal article

Ng J. et al, (2021), Sci Transl Med, 13
REST Protects Dopaminergic Neurons from Mitochondrial and α-Synuclein Oligomer Pathology in an Alpha Synuclein Overexpressing BAC-Transgenic Mouse Model.
Journal article

Ryan BJ. et al, (2021), J Neurosci, 41, 3731 - 3746
Mitochondrial Dysfunction and Mitophagy in Parkinson's Disease: From Mechanism to Therapy.
Journal article

Malpartida AB. et al, (2021), Trends Biochem Sci, 46, 329 - 343
Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer's disease.
Journal article

Bengoa-Vergniory N. et al, (2021), Acta Neuropathol Commun, 9
Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol.
Journal article

Threlfell S. et al, (2021), Front Cell Neurosci, 15

Theme 3 Models

Input Zone-Selective Dysrhythmia in Motor Thalamus after Dopamine Depletion.
Journal article

Nakamura KC. et al, (2021), J Neurosci, 41, 10382 - 10404
Dopamine release in nucleus accumbens is under tonic inhibition by adenosine A1 receptors regulated by astrocytic ENT1 and dysregulated by ethanol
Preprint

Roberts BM. et al, (2021)
Revisiting dopamine-acetylcholine imbalance in Parkinson's disease: Glutamate co-transmission as an exciting partner in crime.
Journal article

Zhang Y-F. and Cragg SJ., (2021), Neuron, 109, 1070 - 1071
Axonal Modulation of Striatal Dopamine Release by Local γ-Aminobutyric Acid (GABA) Signalling.
Journal article

Roberts BM. et al, (2021), Cells, 10
Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol.
Journal article

Threlfell S. et al, (2021), Front Cell Neurosci, 15

2020

Theme 1 Clinical

Dopamine promotes instrumental motivation, but reduces reward-related vigour.
Journal article

Grogan JP. et al, (2020), Elife, 9
The Cortical Basal ganglia Functional Scale (CBFS): Development and preliminary validation.
Journal article

Lang AE. et al, (2020), Parkinsonism Relat Disord, 79, 121 - 126
The association between pain and impulse control behaviours in Parkinson's disease.
Journal article

Kobylecki C. et al, (2020), Parkinsonism Relat Disord, 78, 53 - 55
REM sleep behavior disorder (RBD).
Journal article

Hu MT., (2020), Neurobiol Dis, 143
SMPD1 variants do not have a major role in rapid eye movement sleep behavior disorder.
Journal article

Rudakou U. et al, (2020), Neurobiol Aging, 93, 142.e5 - 142.e7
GBA variants in REM sleep behavior disorder: A multicenter study.
Journal article

Krohn L. et al, (2020), Neurology, 95, e1008 - e1016
Cohort profile: the Oxford Parkinson's Disease Centre Discovery Cohort MRI substudy (OPDC-MRI).
Journal article

Griffanti L. et al, (2020), BMJ Open, 10
Dopamine and reward hypersensitivity in Parkinson's disease with impulse control disorder.
Journal article

Drew DS. et al, (2020), Brain, 143, 2502 - 2518
Serum neuronal exosomes predict and differentiate Parkinson's disease from atypical parkinsonism.
Journal article

Jiang C. et al, (2020), J Neurol Neurosurg Psychiatry, 91, 720 - 729
Spectrum of impulse control behaviours in Parkinson's disease: pathophysiology and management.
Journal article

Kelly MJ. et al, (2020), J Neurol Neurosurg Psychiatry, 91, 703 - 711
Parkinson's disease-associated alterations of the gut microbiome predict disease-relevant changes in metabolic functions.
Journal article

Baldini F. et al, (2020), BMC Biol, 18
A Heterogeneous Sensing Suite for Multisymptom Quantification of Parkinson's Disease.
Journal article

Huo W. et al, (2020), IEEE Trans Neural Syst Rehabil Eng, 28, 1397 - 1406
The Dementias Platform UK (DPUK) Data Portal.
Journal article

Bauermeister S. et al, (2020), Eur J Epidemiol, 35, 601 - 611
Testing Shortened Versions of Smell Tests to Screen for Hyposmia in Parkinson's Disease.
Journal article

Auger SD. et al, (2020), Mov Disord Clin Pract, 7, 394 - 398
Genome-Wide Association Study of Pain in Parkinson's Disease Implicates TRPM8 as a Risk Factor.
Journal article

Williams NM. et al, (2020), Mov Disord, 35, 705 - 707
Fine-Mapping of SNCA in Rapid Eye Movement Sleep Behavior Disorder and Overt Synucleinopathies.
Journal article

Krohn L. et al, (2020), Ann Neurol, 87, 584 - 598
Deep phenotyping of peripheral tissue facilitates mechanistic disease stratification in sporadic Parkinson's disease.
Journal article

Carling PJ. et al, (2020), Prog Neurobiol, 187
Diagnosis Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Syndrome.
Journal article

Jabbari E. et al, (2020), JAMA Neurol, 77, 377 - 387
Blood biomarkers with Parkinson's disease clusters and prognosis: The oxford discovery cohort.
Journal article

Lawton M. et al, (2020), Mov Disord, 35, 279 - 287
Genetic, Structural, and Functional Evidence Link TMEM175 to Synucleinopathies.
Journal article

Krohn L. et al, (2020), Ann Neurol, 87, 139 - 153
Reply to: "Predictors of motor complications in early Parkinson's disease".
Journal article

Baig F. et al, (2020), Mov Disord, 35
Nigrosome 1 imaging in REM sleep behavior disorder and its association with dopaminergic decline.
Journal article

Barber TR. et al, (2020), Ann Clin Transl Neurol, 7, 26 - 35
Book Review of "Ending Parkinson's Disease: A Prescription for Action".
Journal article

Hu MT., (2020), J Parkinsons Dis, 10, 743 - 744
Continuous Real-World Gait Monitoring in Idiopathic REM Sleep Behavior Disorder.
Journal article

Del Din S. et al, (2020), J Parkinsons Dis, 10, 283 - 299
Precompetitive Consensus Building to Facilitate the Use of Digital Health Technologies to Support Parkinson Disease Drug Development through Regulatory Science.
Journal article

Stephenson D. et al, (2020), Digit Biomark, 4, 28 - 49
A Ketone Ester Drink Enhances Endurance Exercise Performance in Parkinson's Disease.
Journal article

Norwitz NG. et al, (2020), Front Neurosci, 14

Theme 2 Cellular

Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells.
Journal article

Vilema-Enríquez G. et al, (2020), J Biol Chem, 295, 17973 - 17985
GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model.
Journal article

Roberts BM. et al, (2020), Nat Commun, 11
CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease.
Journal article

Bengoa-Vergniory N. et al, (2020), Nat Commun, 11
A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders.
Journal article

Agarwal D. et al, (2020), Nat Commun, 11
Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson’s
Journal article

Brimblecombe KR. et al, (2020)
Lysosomal perturbations in human dopaminergic neurons derived from induced pluripotent stem cells with PARK2 mutation.
Journal article

Okarmus J. et al, (2020), Sci Rep, 10
Cohort Profile: the Oxford Parkinson's Disease Centre Discovery Cohort Magnetic Resonance Imaging sub-study (OPDC-MRI)
Journal article

GRIFFANTI L. et al, (2020), BMJ Open
Human-Specific Transcriptome of Ventral and Dorsal Midbrain Dopamine Neurons.
Journal article

Monzón-Sandoval J. et al, (2020), Ann Neurol, 87, 853 - 868
The Dementias Platform UK (DPUK) Data Portal.
Journal article

Bauermeister S. et al, (2020), Eur J Epidemiol, 35, 601 - 611
LRRK2 Is Recruited to Phagosomes and Co-recruits RAB8 and RAB10 in Human Pluripotent Stem Cell-Derived Macrophages.
Journal article

Lee H. et al, (2020), Stem Cell Reports, 14, 940 - 955
Deep phenotyping of peripheral tissue facilitates mechanistic disease stratification in sporadic Parkinson's disease.
Journal article

Carling PJ. et al, (2020), Prog Neurobiol, 187
Recommendations for measuring whisker movements and locomotion in mice with sensory, motor and cognitive deficits.
Journal article

Simanaviciute U. et al, (2020), J Neurosci Methods, 331
Understanding the pathophysiological role of early tau aggregates in Alzheimer's disease by their direct visualisation in situ
Conference paper

Velentza-Almpani E. et al, (2020), NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 46, 42 - 42
Enhancing mitophagy as a therapeutic approach for neurodegenerative diseases.
Chapter

Aman Y. et al, (2020), 155, 169 - 202
What we can learn from iPSC-derived cellular models of Parkinson's disease.
Chapter

Caiazza MC. et al, (2020), 252, 3 - 25
"LRRK2: Autophagy and Lysosomal Activity".
Journal article

Madureira M. et al, (2020), Front Neurosci, 14

Theme 3 Models

GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model.
Journal article

Roberts BM. et al, (2020), Nat Commun, 11
CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease.
Journal article

Bengoa-Vergniory N. et al, (2020), Nat Commun, 11
Diabetes Causes Dysfunctional Dopamine Neurotransmission Favoring Nigrostriatal Degeneration in Mice.
Journal article

Pérez-Taboada I. et al, (2020), Mov Disord, 35, 1636 - 1648
Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson’s
Journal article

Brimblecombe KR. et al, (2020)
State Dependent Beta Oscillations in the Cortico-Basal Ganglia Circuit and their Neuromodulation under Phase-Locked Inputs
Journal article

West TO. et al, (2020)

2019

Theme 1 Clinical

A Qualitative Study on the Impact of First Steps-A Peer-led Educational Intervention for People Newly Diagnosed with Parkinson's Disease.
Journal article

Soundy A. et al, (2019), Behav Sci (Basel), 9
RNA sequencing reveals MMP2 and TGFB1 downregulation in LRRK2 G2019S Parkinson's iPSC-derived astrocytes.
Journal article

Booth HDE. et al, (2019), Neurobiol Dis, 129, 56 - 66
Impulse control disorders in Parkinson disease and RBD: A longitudinal study of severity.
Journal article

Baig F. et al, (2019), Neurology, 93, e675 - e687
Dementia in Parkinson's disease
Chapter

HU M. and BAIG F., (2019), New Oxford Textbook Psychiatry 3e
Predicting motor, cognitive & functional impairment in Parkinson's.
Journal article

Lo C. et al, (2019), Ann Clin Transl Neurol, 6, 1498 - 1509
Predictors of motor complications in early Parkinson's disease: A prospective cohort study.
Journal article

Kelly MJ. et al, (2019), Mov Disord, 34, 1174 - 1183
From dreams to parkinsonism: tracking the journey.
Internet publication

Hu MTM., (2019), 142, 1850 - 1852
Proximity extension assay testing reveals novel diagnostic biomarkers of atypical parkinsonian syndromes.
Journal article

Jabbari E. et al, (2019), J Neurol Neurosurg Psychiatry, 90, 768 - 773
Critical Path for Parkinson's: Catalyzing Innovation for Parkinson's Clinical Trials through Data Sharing and Regulatory Science
Conference paper

Stephenson D. et al, (2019), NEUROLOGY, 92
Detection of REM sleep behaviour disorder by automated polysomnography analysis.
Journal article

Cooray N. et al, (2019), Clin Neurophysiol, 130, 505 - 514
Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study.
Journal article

Postuma RB. et al, (2019), Brain, 142, 744 - 759
Neuroimaging of Rapid Eye Movement Sleep Behavior Disorder
Journal article

HU MICHELE. et al, (2019), International Review of Neurobiology
Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes.
Journal article

Lang C. et al, (2019), Cell Stem Cell, 24, 93 - 106.e6
Sleep Disturbance as Potential Risk and Progression Factor for Parkinson's Disease.
Journal article

Bohnen NI. and Hu MTM., (2019), J Parkinsons Dis, 9, 603 - 614
Neuroimaging of Rapid Eye Movement Sleep Behavior Disorder.
Chapter

Bourgouin P-A. et al, (2019), 144, 185 - 210
The Mechanisms by Which the Ketone Body D-β-Hydroxybutyrate May Improve the Multiple Cellular Pathologies of Parkinson's Disease.
Journal article

Norwitz NG. et al, (2019), Front Nutr, 6

Theme 2 Cellular

Application of CRISPR/Cas9 editing and digital droplet PCR in human iPSCs to generate novel knock-in reporter lines to visualize dopaminergic neurons.
Journal article

Überbacher C. et al, (2019), Stem Cell Res, 41
Perturbations in RhoA signalling cause altered migration and impaired neuritogenesis in human iPSC-derived neural cells with PARK2 mutation.
Journal article

Bogetofte H. et al, (2019), Neurobiol Dis, 132
Lysosomal Dysfunction at the Centre of Parkinson's Disease and Frontotemporal Dementia/Amyotrophic Lateral Sclerosis.
Journal article

Wallings RL. et al, (2019), Trends Neurosci, 42, 899 - 912
Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson's disease.
Journal article

Benkert J. et al, (2019), Nat Commun, 10
Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior.
Journal article

Hunn BHM. et al, (2019), Cell Rep, 29, 920 - 931.e7
RNA sequencing reveals MMP2 and TGFB1 downregulation in LRRK2 G2019S Parkinson's iPSC-derived astrocytes.
Journal article

Booth HDE. et al, (2019), Neurobiol Dis, 129, 56 - 66
LRRK2 interacts with the vacuolar-type H+-ATPase pump a1 subunit to regulate lysosomal function.
Journal article

Wallings R. et al, (2019), Hum Mol Genet, 28, 2696 - 2710
The A30P α-synuclein mutation decreases subventricular zone proliferation.
Journal article

Zhang X-M. et al, (2019), Hum Mol Genet, 28, 2283 - 2294
Astrocytic striatal GABA transporter activity governs dopamine release and shows maladaptive downregulation in early parkinsonism
Journal article

Roberts BM. et al, (2019)
An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2.
Journal article

Connor-Robson N. et al, (2019), Neurobiol Dis, 127, 512 - 526
Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons.
Journal article

Zambon F. et al, (2019), Hum Mol Genet, 28, 2001 - 2013
Oxidation Resistance 1 Modulates Glycolytic Pathways in the Cerebellum via an Interaction with Glucose-6-Phosphate Isomerase.
Journal article

Finelli MJ. et al, (2019), Mol Neurobiol, 56, 1558 - 1577
Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes.
Journal article

Lang C. et al, (2019), Cell Stem Cell, 24, 93 - 106.e6
Using human iPSC derived dopamine neurons to investigate physiological changes in Parkinson Disease
Conference paper

Beccano-Kelly D. et al, (2019), ACTA PHYSIOLOGICA, 227
Targeting Alpha-Synuclein as a Therapy for Parkinson's Disease.
Journal article

Fields CR. et al, (2019), Front Mol Neurosci, 12
Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction.
Journal article

Gordon D. et al, (2019), Neurobiol Dis, 121, 148 - 162
The neuronal calcium sensor NCS-1 is involved in defining vulnerability of Substantia nigra dopaminergic neurons to degenration in Parkinson's disease
Conference paper

Simons C. et al, (2019), ACTA PHYSIOLOGICA, 227
PARK2 Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived Neurons.
Journal article

Bogetofte H. et al, (2019), Front Cell Neurosci, 13

Theme 3 Models

Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility.
Journal article

Kosillo P. et al, (2019), Nat Commun, 10
Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior.
Journal article

Hunn BHM. et al, (2019), Cell Rep, 29, 920 - 931.e7
Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter.
Journal article

Condon MD. et al, (2019), Nat Commun, 10
Calbindin-D28K Limits Dopamine Release in Ventral but Not Dorsal Striatum by Regulating Ca2+ Availability and Dopamine Transporter Function.
Journal article

Brimblecombe KR. et al, (2019), ACS Chem Neurosci, 10, 3419 - 3426
Temporal evolution of beta bursts in the parkinsonian cortical and basal ganglia network.
Journal article

Cagnan H. et al, (2019), Proc Natl Acad Sci U S A, 116, 16095 - 16104
Astrocytic striatal GABA transporter activity governs dopamine release and shows maladaptive downregulation in early parkinsonism
Journal article

Roberts BM. et al, (2019)
Thalamocortical dynamics underlying spontaneous transitions in beta power in Parkinsonism.
Journal article

Reis C. et al, (2019), Neuroimage, 193, 103 - 114
A Hippocampus-Accumbens Tripartite Neuronal Motif Guides Appetitive Memory in Space.
Journal article

Trouche S. et al, (2019), Cell, 176, 1393 - 1406.e16
Dopamine neuron-derived IGF-1 controls dopamine neuron firing, skill learning, and exploration.
Journal article

Pristerà A. et al, (2019), Proc Natl Acad Sci U S A, 116, 3817 - 3826
Inhibition of Nigrostriatal Dopamine Release by Striatal GABAA and GABAB Receptors.
Journal article

Lopes EF. et al, (2019), J Neurosci, 39, 1058 - 1065

2018

Theme 1 Clinical

Detection of alpha-synuclein conformational variants from gastro-intestinal biopsy tissue as a potential biomarker for Parkinson's disease.
Journal article

Ruffmann C. et al, (2018), Neuropathol Appl Neurobiol, 44, 722 - 736
Developing and validating Parkinson's disease subtypes and their motor and cognitive progression.
Journal article

Lawton M. et al, (2018), J Neurol Neurosurg Psychiatry, 89, 1279 - 1287
Exploring variability in basal ganglia connectivity with functional MRI in healthy aging.
Journal article

Griffanti L. et al, (2018), Brain Imaging Behav, 12, 1822 - 1827
A detailed clinical study of pain in 1957 participants with early/moderate Parkinson's disease.
Journal article

Silverdale MA. et al, (2018), Parkinsonism Relat Disord, 56, 27 - 32
Smartphone motor testing to distinguish idiopathic REM sleep behavior disorder, controls, and PD.
Journal article

Arora S. et al, (2018), Neurology, 91, e1528 - e1538
Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells.
Journal article

Smith AM. et al, (2018), Mov Disord, 33, 1580 - 1590
Apathy in rapid eye movement sleep behaviour disorder is associated with serotonin depletion in the dorsal raphe nucleus.
Journal article

Barber TR. et al, (2018), Brain, 141, 2848 - 2854
Neuromelanin-MRI in REM sleep behaviour disorder predicts dopaminergic dysfunction and clinical risk of Parkinson's disease
Conference paper

Barber T. et al, (2018), MOVEMENT DISORDERS, 33, S79 - S79
Potential Metabolomic Linkage in Blood between Parkinson's Disease and Traumatic Brain Injury.
Journal article

Fiandaca MS. et al, (2018), Metabolites, 8
Automating the Detection of REM Sleep Behaviour Disorder.
Journal article

Cooray N. et al, (2018), Annu Int Conf IEEE Eng Med Biol Soc, 2018, 1460 - 1463
Full sequencing and haplotype analysis of MAPT in Parkinson's disease and rapid eye movement sleep behavior disorder.
Journal article

Li J. et al, (2018), Mov Disord, 33, 1016 - 1020
LRRK2 protective haplotype and full sequencing study in REM sleep behavior disorder.
Journal article

Ouled Amar Bencheikh B. et al, (2018), Parkinsonism Relat Disord, 52, 98 - 101
Dopamine Modulates Option Generation for Behavior.
Journal article

Ang Y-S. et al, (2018), Curr Biol, 28, 1561 - 1569.e3
Distinct effects of apathy and dopamine on effort-based decision-making in Parkinson's disease.
Journal article

Le Heron C. et al, (2018), Brain, 141, 1455 - 1469
Cortical structural involvement and cognitive dysfunction in early Parkinson's disease.
Journal article

Klein JC. et al, (2018), NMR Biomed, 31
Apathy in rapid eye movement sleep behaviour disorder is common and under-recognized.
Journal article

Barber TR. et al, (2018), Eur J Neurol, 25, 469 - e32
Cerebrospinal fluid macrophage biomarkers in amyotrophic lateral sclerosis.
Journal article

Thompson AG. et al, (2018), Ann Neurol, 83, 258 - 268
The Luxembourg Parkinson's Study: A Comprehensive Approach for Stratification and Early Diagnosis.
Journal article

Hipp G. et al, (2018), Front Aging Neurosci, 10

Theme 2 Cellular

Smartphone motor testing to distinguish idiopathic REM sleep behavior disorder, controls, and PD.
Journal article

Arora S. et al, (2018), Neurology, 91, e1528 - e1538
Are rodent models of Parkinson's disease behaving as they should?
Journal article

Vingill S. et al, (2018), Behav Brain Res, 352, 133 - 141
Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells.
Journal article

Smith AM. et al, (2018), Mov Disord, 33, 1580 - 1590
Potential Metabolomic Linkage in Blood between Parkinson's Disease and Traumatic Brain Injury.
Journal article

Fiandaca MS. et al, (2018), Metabolites, 8
Convergent pathways in Parkinson's disease.
Journal article

Cherubini M. and Wade-Martins R., (2018), Cell Tissue Res, 373, 79 - 90
Phenotypic Screening and Functional Genetics in FTD/ALS
Conference paper

Humble SW. et al, (2018), MOLECULAR BIOLOGY OF THE CELL, 29, 343 - 344

Theme 3 Models

Temporal evolution of beta bursts in the parkinsonian cortico-basal ganglia network
Journal article

Cagnan H. et al, (2018)
Thalamocortical dynamics underlying spontaneous transitions in beta power in Parkinsonism
Journal article

Reis C. et al, (2018)
Targeted Activation of Cholinergic Interneurons Accounts for the Modulation of Dopamine by Striatal Nicotinic Receptors.
Journal article

Brimblecombe KR. et al, (2018), eNeuro, 5
Pauses in Cholinergic Interneuron Activity Are Driven by Excitatory Input and Delayed Rectification, with Dopamine Modulation.
Journal article

Zhang Y-F. et al, (2018), Neuron, 98, 918 - 925.e3
Propagation of beta/gamma rhythms in the cortico-basal ganglia circuits of the parkinsonian rat.
Journal article

West TO. et al, (2018), J Neurophysiol, 119, 1608 - 1628
Structural and molecular heterogeneity of calretinin-expressing interneurons in the rodent and primate striatum.
Journal article

Garas FN. et al, (2018), J Comp Neurol, 526, 877 - 898

2017

Theme 1 Clinical

Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease.
Journal article

Robak LA. et al, (2017), Brain, 140, 3191 - 3203
Considerations in the Use of MDS Research Criteria for Prodromal Parkinson's in Rapid Eye Movement Sleep Behaviour Disorder and Population Cohorts.
Journal article

Barber TR. et al, (2017), Sleep, 40
Prodromal Parkinsonism and Neurodegenerative Risk Stratification in REM Sleep Behavior Disorder.
Journal article

Barber TR. et al, (2017), Sleep, 40
Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases.
Journal article

Witoelar A. et al, (2017), JAMA Neurol, 74, 780 - 792
Cortical involvement in early Parkinson's disease: evidence from multimodal MRI
Conference paper

Klein JC. et al, (2017), EUROPEAN JOURNAL OF NEUROLOGY, 24, 92 - 92
No genetic association between attention-deficit/hyperactivity disorder (ADHD) and Parkinson's disease in nine ADHD candidate SNPs.
Journal article

Geissler JM. et al, (2017), Atten Defic Hyperact Disord, 9, 121 - 127
Personality and addictive behaviours in early Parkinson's disease and REM sleep behaviour disorder.
Journal article

Baig F. et al, (2017), Parkinsonism Relat Disord, 37, 72 - 78
Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson's disease.
Journal article

Sandor C. et al, (2017), Hum Mol Genet, 26, 552 - 566
Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing.
Journal article

Jansen IE. et al, (2017), Genome Biol, 18
Whole-exome sequencing of 228 patients with sporadic Parkinson's disease.
Journal article

Sandor C. et al, (2017), Sci Rep, 7
The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder.
Journal article

Gan-Or Z. et al, (2017), Neurobiol Aging, 49, 218.e13 - 218.e15
Neuroimaging in pre-motor Parkinson's disease.
Journal article

Barber TR. et al, (2017), Neuroimage Clin, 15, 215 - 227
DISEASE STRATIFICATION IN SPORADIC PARKINSON'S DISEASE
Conference paper

Carling P. et al, (2017), JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 88, A31 - A32

Theme 2 Cellular

Alpha-synuclein oligomers: a new hope.
Journal article

Bengoa-Vergniory N. et al, (2017), Acta Neuropathol, 134, 819 - 838
Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders.
Journal article

Lai MC. et al, (2017), Mol Neurodegener, 12
Loss of MicroRNA-7 Regulation Leads to α-Synuclein Accumulation and Dopaminergic Neuronal Loss In Vivo.
Journal article

McMillan KJ. et al, (2017), Mol Ther, 25, 2404 - 2414
Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages.
Journal article

Haenseler W. et al, (2017), Sci Rep, 7
MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in iPSC-Derived Dopamine Neurons.
Journal article

Beevers JE. et al, (2017), Stem Cell Reports, 9, 587 - 599
A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response.
Journal article

Haenseler W. et al, (2017), Stem Cell Reports, 8, 1727 - 1742
A Genomic DNA Reporter Screen Identifies Squalene Synthase Inhibitors That Act Cooperatively with Statins to Upregulate the Low-Density Lipoprotein Receptor.
Journal article

Kerr AG. et al, (2017), J Pharmacol Exp Ther, 361, 417 - 428
The Role of Astrocyte Dysfunction in Parkinson's Disease Pathogenesis.
Journal article

Booth HDE. et al, (2017), Trends Neurosci, 40, 358 - 370
A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance.
Journal article

Bailey J. et al, (2017), Free Radic Biol Med, 104, 214 - 225
Increased 4R tau expression and behavioural changes in a novel MAPT-N296H genomic mouse model of tauopathy.
Journal article

Wobst HJ. et al, (2017), Sci Rep, 7
Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson's disease.
Journal article

Sandor C. et al, (2017), Hum Mol Genet, 26, 552 - 566
Whole-exome sequencing of 228 patients with sporadic Parkinson's disease.
Journal article

Sandor C. et al, (2017), Sci Rep, 7
Global proteomic and transcriptomic analysis of the LRRK2 G2019S mutation in iPSC-derived midbrain dopaminergic neurons
Poster

Martin J. et al, (2017), MOLECULAR & CELLULAR PROTEOMICS, 16, S52 - S52
Preclinical development of a vaccine against oligomeric alpha-synuclein based on virus-like particles.
Journal article

Doucet M. et al, (2017), PLoS One, 12
Wild-Type, but Not Mutant N296H, Human Tau Restores Aβ-Mediated Inhibition of LTP in Tau-/- mice.
Journal article

Vargas-Caballero M. et al, (2017), Front Neurosci, 11
DISEASE STRATIFICATION IN SPORADIC PARKINSON'S DISEASE
Conference paper

Carling P. et al, (2017), JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 88, A31 - A32

Theme 3 Models

A Population of Indirect Pathway Striatal Projection Neurons Is Selectively Entrained to Parkinsonian Beta Oscillations.
Journal article

Sharott A. et al, (2017), J Neurosci, 37, 9977 - 9998
The Striosome and Matrix Compartments of the Striatum: A Path through the Labyrinth from Neurochemistry toward Function.
Journal article

Brimblecombe KR. and Cragg SJ., (2017), ACS Chem Neurosci, 8, 235 - 242
Pauses in Striatal Cholinergic Interneurons: What is Revealed by Their Common Themes and Variations?
Journal article

Zhang Y-F. and Cragg SJ., (2017), Front Syst Neurosci, 11

2016

Theme 1 Clinical

Equating scores of the University of Pennsylvania Smell Identification Test and Sniffin' Sticks test in patients with Parkinson's disease.
Journal article

Lawton M. et al, (2016), Parkinsonism Relat Disord, 33, 96 - 101
Paradoxical facilitation after depotentiation protocol can precede dyskinesia onset in early Parkinson's disease.
Journal article

Lago-Rodriguez A. et al, (2016), Exp Brain Res, 234, 3659 - 3667
Statins are underused in recent-onset Parkinson's disease with increased vascular risk: findings from the UK Tracking Parkinson's and Oxford Parkinson's Disease Centre (OPDC) discovery cohorts.
Journal article

Swallow DMA. et al, (2016), J Neurol Neurosurg Psychiatry, 87, 1183 - 1190
Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies.
Journal article

Fairfoul G. et al, (2016), Ann Clin Transl Neurol, 3, 812 - 818
Reward sensitivity deficits modulated by dopamine are associated with apathy in Parkinson's disease.
Journal article

Muhammed K. et al, (2016), Brain, 139, 2706 - 2721
Basal ganglia dysfunction in idiopathic REM sleep behaviour disorder parallels that in early Parkinson's disease.
Journal article

Rolinski M. et al, (2016), Brain, 139, 2224 - 2234
Acute variegate porphyria presenting with reversible cerebral vasoconstriction.
Journal article

Webb AJS. et al, (2016), Clin Neurol Neurosurg, 146, 102 - 104
Validation of conversion between mini-mental state examination and montreal cognitive assessment.
Journal article

Lawton M. et al, (2016), Mov Disord, 31, 593 - 596
ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons.
Journal article

Fernandes HJR. et al, (2016), Stem Cell Reports, 6, 342 - 356
Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy.
Journal article

Lesage S. et al, (2016), Am J Hum Genet, 98, 500 - 513
Colonic alpha-synuclein: a potential diagnostic biomarker in Parkinson's disease
Conference paper

Ruffmann C. et al, (2016), NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 42, 51 - 51
Colonic alpha-synuclein: A potential diagnostic biomarker in Parkinson's disease
Conference paper

Ruffmann C. et al, (2016), MOVEMENT DISORDERS, 31, S584 - S584
Challenges in the reproducibility of clinical studies with resting state fMRI: An example in early Parkinson's disease.
Journal article

Griffanti L. et al, (2016), Neuroimage, 124, 704 - 713
Visual short-term memory deficits in REM sleep behaviour disorder mirror those in Parkinson's disease.
Journal article

Rolinski M. et al, (2016), Brain, 139, 47 - 53
Prodromal Markers in Parkinson's Disease: Limitations in Longitudinal Studies and Lessons Learned.
Journal article

Heinzel S. et al, (2016), Front Aging Neurosci, 8
Aiming for Study Comparability in Parkinson's Disease: Proposal for a Modular Set of Biomarker Assessments to be Used in Longitudinal Studies.
Journal article

Lerche S. et al, (2016), Front Aging Neurosci, 8

Theme 2 Cellular

Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease.
Journal article

Vazquez-Arango P. et al, (2016), Nucleic Acids Res, 44, 10960 - 10973
C-type natriuretic peptide and natriuretic peptide receptor B signalling inhibits cardiac sympathetic neurotransmission and autonomic function.
Journal article

Buttgereit J. et al, (2016), Cardiovasc Res, 112, 637 - 644
Episomal Nonviral Gene Therapy Vectors Slow Progression of Atherosclerosis in a Model of Familial Hypercholesterolemia.
Journal article

Kerr AG. et al, (2016), Mol Ther Nucleic Acids, 5
Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies.
Journal article

Fairfoul G. et al, (2016), Ann Clin Transl Neurol, 3, 812 - 818
C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell-Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.
Journal article

Dafinca R. et al, (2016), Stem Cells, 34, 2063 - 2078
The infectious BAC genomic DNA expression library: a high capacity vector system for functional genomics.
Journal article

Lufino MMP. et al, (2016), Sci Rep, 6
Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism.
Journal article

Dodson PD. et al, (2016), Proc Natl Acad Sci U S A, 113, E2180 - E2188
Improving the physiological realism of experimental models.
Journal article

Vinnakota KC. et al, (2016), Interface Focus, 6
ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons.
Journal article

Fernandes HJR. et al, (2016), Stem Cell Reports, 6, 342 - 356
LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function.
Journal article

Sloan M. et al, (2016), Hum Mol Genet, 25, 951 - 963
TDP-43 is cytoplasmically mislocalized and associated with impaired stress responses and survival of primary neurons from symptomatic amyotrophic lateral sclerosis (ALS) mice
Conference paper

Farrimond L. et al, (2016), EUROPEAN JOURNAL OF NEUROLOGY, 23, 390 - 391
Colonic alpha-synuclein: A potential diagnostic biomarker in Parkinson's disease
Conference paper

Ruffmann C. et al, (2016), MOVEMENT DISORDERS, 31, S584 - S584
Absence of wide-spread mis-splicing in the preclinical phase of a native promoter driven TDP-43 mouse model of ALS
Conference paper

Scaber J. et al, (2016), EUROPEAN JOURNAL OF NEUROLOGY, 23, 797 - 797
Using a Novel Combinatorial Non-Viral Vector and Small Molecules to Treat Familial Hypercholesterolaemia (FH)
Conference paper

Kerr AG. et al, (2016), MOLECULAR THERAPY, 24, S9 - S10
WORKSHOP 3.1: NOVEL THERAPIES. A NOVEL COMBINATORIAL NON-VIRAL VECTOR TO TREAT FAMILIAL HYPERCHOLESTEROLAEMIA (FH)
Conference paper

Kerr A. et al, (2016), ATHEROSCLEROSIS, 252, E238 - E238
Episomal Nonviral Gene Therapy Vectors Slow Progression of Atherosclerosis in a Model of Familial Hypercholesterolemia.
Journal article

Kerr AG. et al, (2016), Mol Ther Nucleic Acids, 5
Commentary: Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models.
Journal article

Fernandes HJR. et al, (2016), Front Neurosci, 10
Can pathological oligomeric proteins make good biomarkers? (Commentary on Williams et al.).
Journal article

Roberts RF. and Wade-Martins R., (2016), Eur J Neurosci, 43, 1 - 2

Theme 3 Models

Cortical Control of Striatal Dopamine Transmission via Striatal Cholinergic Interneurons.
Journal article

Kosillo P. et al, (2016), Cereb Cortex, 26, 4160 - 4169
Secretagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneurons.
Journal article

Garas FN. et al, (2016), Elife, 5
Striatal dopamine neurotransmission: regulation of release and uptake.
Journal article

Sulzer D. et al, (2016), Basal Ganglia, 6, 123 - 148
Properties of Neurons in External Globus Pallidus Can Support Optimal Action Selection.
Journal article

Bogacz R. et al, (2016), PLoS Comput Biol, 12
Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism.
Journal article

Dodson PD. et al, (2016), Proc Natl Acad Sci U S A, 113, E2180 - E2188
LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function.
Journal article

Sloan M. et al, (2016), Hum Mol Genet, 25, 951 - 963
Action initiation shapes mesolimbic dopamine encoding of future rewards.
Journal article

Syed ECJ. et al, (2016), Nat Neurosci, 19, 34 - 36
Regulation of Extracellular Dopamine: Release and Uptake
Chapter

Sulzer D. et al, (2016), Handbook of Behavioral Neuroscience, 24, 373 - 402

2015

Theme 1 Clinical

Delineating nonmotor symptoms in early Parkinson's disease and first-degree relatives.
Journal article

Baig F. et al, (2015), Mov Disord, 30, 1759 - 1766
Dopamine enhances willingness to exert effort for reward in Parkinson's disease.
Journal article

Chong TT-J. et al, (2015), Cortex, 69, 40 - 46
Pattern of working memory deficit in REM sleep behaviour disorder is the same as in Parkinson's disease
Conference paper

Rolinski M. et al, (2015), MOVEMENT DISORDERS, 30, S347 - S348
Widespread functional, but not structural, changes in patients with idiopathic REM sleep behaviour disorder
Conference paper

Rolinski M. et al, (2015), EUROPEAN JOURNAL OF NEUROLOGY, 22, 44 - 45
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption
Journal article

Cornelis MC. et al, (2015), Molecular Psychiatry, 20, 647 - 656
Antisaccades and executive dysfunction in early drug-naive Parkinson's disease: The discovery study.
Journal article

Antoniades CA. et al, (2015), Mov Disord, 30, 843 - 847
Identification of distinct circulating exosomes in Parkinson's disease.
Journal article

Tomlinson PR. et al, (2015), Ann Clin Transl Neurol, 2, 353 - 361
Functional connectivity in the basal ganglia network differentiates PD patients from controls.
Journal article

Montgomery EB., (2015), Neurology, 84
Author response.
Journal article

Mackay CE. et al, (2015), Neurology, 84
Methods in Neuroepidemiology Characterization of European Longitudinal Cohort Studies in Parkinson's Disease--Report of the JPND Working Group BioLoC-PD.
Journal article

Lerche S. et al, (2015), Neuroepidemiology, 45, 282 - 297
Precompetitive Data Sharing as a Catalyst to Address Unmet Needs in Parkinson's Disease.
Journal article

Stephenson D. et al, (2015), J Parkinsons Dis, 5, 581 - 594
Parkinson's Disease Subtypes in the Oxford Parkinson Disease Centre (OPDC) Discovery Cohort.
Journal article

Lawton M. et al, (2015), J Parkinsons Dis, 5, 269 - 279
Aberrant functional connectivity within the basal ganglia of patients with Parkinson's disease.
Journal article

Rolinski M. et al, (2015), Neuroimage Clin, 8, 126 - 132

Theme 2 Cellular

Protein-protein interaction networks identify targets which rescue the MPP+ cellular model of Parkinson's disease.
Journal article

Keane H. et al, (2015), Sci Rep, 5
Encyclopedia of Inflammatory Diseases
Chapter

Ryan BJ. et al, (2015), Encyclopedia of Inflammatory Diseases
Restoration of Physiologically Responsive Low-Density Lipoprotein Receptor-Mediated Endocytosis in Genetically Deficient Induced Pluripotent Stem Cells.
Journal article

Ramakrishnan VM. et al, (2015), Sci Rep, 5
Delivery of the 135kb human frataxin genomic DNA locus gives rise to different frataxin isoforms
Journal article

Pérez-Luz S. et al, (2015), Genomics, 106, 76 - 82
Delivery of the 135 kb human frataxin genomic DNA locus gives rise to different frataxin isoforms.
Journal article

Pérez-Luz S. et al, (2015), Genomics, 106, 76 - 82
Expanded GAA repeats impair FXN gene expression and reposition the FXN locus to the nuclear lamina in single cells.
Journal article

Silva AM. et al, (2015), Hum Mol Genet, 24, 3457 - 3471
Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brain.
Journal article

Roberts RF. et al, (2015), Brain, 138, 1642 - 1657
Parkinson's disease in GTP cyclohydrolase 1 mutation carriers.
Journal article

Ryan BJ. et al, (2015), Brain, 138
Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease.
Journal article

Ryan BJ. et al, (2015), Trends Biochem Sci, 40, 200 - 210
Oxidative and other posttranslational modifications in extracellular vesicle biology.
Journal article

Szabó-Taylor K. et al, (2015), Semin Cell Dev Biol, 40, 8 - 16
Identification of distinct circulating exosomes in Parkinson's disease.
Journal article

Tomlinson PR. et al, (2015), Ann Clin Transl Neurol, 2, 353 - 361
Investigating the function of microtubule-associated protein tau (MAPT) and its genetic association with Parkinson’s using human iPSC-derived dopamine neurons
Conference paper

Beevers JE. et al, (2015)
A requirement for Gch1 and tetrahydrobiopterin in embryonic development.
Journal article

Douglas G. et al, (2015), Dev Biol, 399, 129 - 138
Impaired intracellular trafficking defines early Parkinson's disease
Journal article

Hunn BHM. et al, (2015), Trends in Neurosciences, 38, 178 - 188
Impaired intracellular trafficking defines early Parkinson's disease.
Journal article

Hunn BHM. et al, (2015), Trends Neurosci, 38, 178 - 188
TARDBP pathogenic mutations increase cytoplasmic translocation of TDP-43 and cause reduction of endoplasmic reticulum Ca²⁺ signaling in motor neurons.
Journal article

Mutihac R. et al, (2015), Neurobiol Dis, 75, 64 - 77
Modelling amyotrophic lateral sclerosis (ALS) using mutant and CAS9/CRISPR-corrected motor neurons from patients with C9ORE72 mutations reveals disease-specific cellular phenotypes
Conference paper

Mutihac R. et al, (2015), JOURNAL OF THE NEUROLOGICAL SCIENCES, 357, E48 - E48
Growth Arrest Specific 1 (Gas1) Gene Overexpression in Liver Reduces the In Vivo Progression of Murine Hepatocellular Carcinoma and Partially Restores Gene Expression Levels.
Journal article

Sacilotto N. et al, (2015), PLoS One, 10
Generation of an Engineered, Vascularized, iPSC-derived Hepatic Module to Mitigate Genetic Disorders
Conference paper

Ramakrishnan VM. et al, (2015), TISSUE ENGINEERING PART A, 21, S242 - S242

Theme 3 Models

The impact of a parkinsonian lesion on dynamic striatal dopamine transmission depends on nicotinic receptor activation.
Journal article

Jennings KA. et al, (2015), Neurobiol Dis, 82, 262 - 268
Transcription factors FOXA1 and FOXA2 maintain dopaminergic neuronal properties and control feeding behavior in adult mice.
Journal article

Pristerà A. et al, (2015), Proc Natl Acad Sci U S A, 112, E4929 - E4938
Substance P Weights Striatal Dopamine Transmission Differently within the Striosome-Matrix Axis.
Journal article

Brimblecombe KR. and Cragg SJ., (2015), J Neurosci, 35, 9017 - 9023
Prototypic and arkypallidal neurons in the dopamine-intact external globus pallidus.
Journal article

Abdi A. et al, (2015), J Neurosci, 35, 6667 - 6688
Distinct developmental origins manifest in the specialized encoding of movement by adult neurons of the external globus pallidus.
Journal article

Dodson PD. et al, (2015), Neuron, 86, 501 - 513
Impaired intracellular trafficking defines early Parkinson's disease
Journal article

Hunn BHM. et al, (2015), Trends in Neurosciences, 38, 178 - 188
Impaired intracellular trafficking defines early Parkinson's disease.
Journal article

Hunn BHM. et al, (2015), Trends Neurosci, 38, 178 - 188
Gating of dopamine transmission by calcium and axonal N-, Q-, T- and L-type voltage-gated calcium channels differs between striatal domains.
Journal article

Brimblecombe KR. et al, (2015), J Physiol, 593, 929 - 946
Large intercalated neurons of amygdala relay noxious sensory information.
Journal article

Bienvenu TCM. et al, (2015), J Neurosci, 35, 2044 - 2057
Ni(2+) affects dopamine uptake which limits suitability as inhibitor of T-type voltage-gated Ca(2+) channels.
Journal article

Brimblecombe KR. and Cragg SJ., (2015), ACS Chem Neurosci, 6, 124 - 129
COUPLING VOLTAMMETRY WITH OPTOGENETICS TO REVEAL AXONAL CONTROL OF DOPAMINE TRANSMISSION BY STRIATAL ACETYLCHOLINE
Chapter

Kosillo P. et al, (2015), COMPENDIUM OF IN VIVO MONITORING IN REAL-TIME MOLECULAR NEUROSCIENCE, VOL 1: FUNDAMENTALS AND APPLICATIONS, 201 - 223

2014

Theme 1 Clinical

Letter in response to Picillo etal., in relation to Szewczyk-Krolikowski etal.: The influence of age and gender on motor and non-motor features of early Parkinson's disease: Initial findings from the Oxford Parkinson disease Center (OPDC) discovery cohort
Journal article

Ben-Shlomo Y. et al, (2014), Parkinsonism and Related Disorders, 20, 1321 - 1322
Letter in response to Picillo et al., in relation to Szewczyk-Krolikowski et al.: the influence of age and gender on motor and non-motor features of early Parkinson's disease: initial findings from the Oxford Parkinson disease Center (OPDC) discovery cohort.
Journal article

Ben-Shlomo Y. et al, (2014), Parkinsonism Relat Disord, 20, 1321 - 1322
An impedimetric assay of α-synuclein autoantibodies in early stage Parkinson's disease
Journal article

Xu Q. et al, (2014), RSC Advances, 4, 58773 - 58777
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
Journal article

Nalls MA. et al, (2014), Nat Genet, 46, 989 - 993
Visual short-term memory deficits associated with GBA mutation and Parkinson's disease.
Journal article

Zokaei N. et al, (2014), Brain, 137, 2303 - 2311
Functional connectivity in the basal ganglia network differentiates PD patients from controls.
Journal article

Szewczyk-Krolikowski K. et al, (2014), Neurology, 83, 208 - 214
REM sleep behaviour disorder is associated with worse quality of life and other non-motor features in early Parkinson's disease.
Journal article

Rolinski M. et al, (2014), J Neurol Neurosurg Psychiatry, 85, 560 - 566
Comprehensive morphometry of subcortical grey matter structures in early-stage Parkinson's disease.
Journal article

Menke RAL. et al, (2014), Hum Brain Mapp, 35, 1681 - 1690
Predictors of cognitive impairment in an early stage Parkinson's disease cohort.
Journal article

Hu MTM. et al, (2014), Mov Disord, 29, 351 - 359
REM sleep behaviour disorder is associated with worse quality of life and other non-motor features in early Parkinson's disease
Journal article

Rolinski M. et al, (2014), Journal of Neurology, Neurosurgery and Psychiatry, 85, 560 - 566
The influence of age and gender on motor and non-motor features of early Parkinson's disease: Initial findings from the Oxford Parkinson Disease Center (OPDC) discovery cohort
Journal article

Szewczyk-Krolikowski K. et al, (2014), Parkinsonism and Related Disorders, 20, 99 - 105
The influence of age and gender on motor and non-motor features of early Parkinson's disease: initial findings from the Oxford Parkinson Disease Center (OPDC) discovery cohort.
Journal article

Szewczyk-Krolikowski K. et al, (2014), Parkinsonism Relat Disord, 20, 99 - 105

Theme 2 Cellular

Investigating the function of microtubule-associated protein tau (MAPT) and its genetic association with Parkinson’s using human iPSC-derived dopamine neurons
Conference paper

Beevers JE. et al, (2014)
An impedimetric assay of α-synuclein autoantibodies in early stage Parkinson's disease
Journal article

Xu Q. et al, (2014), RSC Advances, 4, 58773 - 58777
R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome.
Journal article

Groh M. et al, (2014), PLoS Genet, 10
α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease.
Journal article

Ryan BJ. et al, (2014), Free Radic Biol Med, 67, 58 - 68
Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse.
Journal article

Taylor TN. et al, (2014), Neurobiol Dis, 62, 193 - 207
Familial Alzheimer's disease coding mutations reduce Presenilin-1 expression in a novel genomic locus reporter model.
Journal article

Ahmadi S. and Wade-Martins R., (2014), Neurobiol Aging, 35, 443.e5 - 443.e16
Generation and LDLR Functional Correction of Familial Hypercholesterolemia iPSC With Physiologically Responsive Non-Integrating BAC Vector
Conference paper

Ramakrishnan VM. et al, (2014), CIRCULATION, 130
C9orf72 Hexanucleotide Expansion Mutations Alter Calcium Signalling in ALS-FTD Patient iPSC-Derived Motor Neurons
Conference paper

Mutihac R. et al, (2014), ANNALS OF NEUROLOGY, 76, S121 - S121
Physiological characterisation of human iPS-derived dopaminergic neurons.
Journal article

Hartfield EM. et al, (2014), PLoS One, 9
Oxidative post-translational modifications and their involvement in the pathogenesis of autoimmune diseases.
Journal article

Ryan BJ. et al, (2014), Redox Biol, 2, 715 - 724
Autoantibodies to posttranslational modifications in rheumatoid arthritis.
Journal article

Burska AN. et al, (2014), Mediators Inflamm, 2014
Detection and characterization of autoantibodies against modified self-proteins in SLE sera after exposure to reactive oxygen and nitrogen species.
Journal article

Ryan BJ. and Eggleton P., (2014), Methods Mol Biol, 1134, 163 - 171
The influence of age and gender on motor and non-motor features of early Parkinson's disease: Initial findings from the Oxford Parkinson Disease Center (OPDC) discovery cohort
Journal article

Szewczyk-Krolikowski K. et al, (2014), Parkinsonism and Related Disorders, 20, 99 - 105
The influence of age and gender on motor and non-motor features of early Parkinson's disease: initial findings from the Oxford Parkinson Disease Center (OPDC) discovery cohort.
Journal article

Szewczyk-Krolikowski K. et al, (2014), Parkinsonism Relat Disord, 20, 99 - 105
Parkinson's disease in a dish - Using stem cells as a molecular tool.
Journal article

Badger JL. et al, (2014), Neuropharmacology, 76 Pt A, 88 - 96

Theme 3 Models

Effective connectivity of the subthalamic nucleus-globus pallidus network during Parkinsonian oscillations
Journal article

Nevado-Holgado AJ. et al, (2014), Journal of Physiology, 592, 1429 - 1455
Cortical and thalamic excitation mediate the multiphasic responses of striatal cholinergic interneurons to motivationally salient stimuli.
Journal article

Doig NM. et al, (2014), J Neurosci, 34, 3101 - 3117
Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse.
Journal article

Taylor TN. et al, (2014), Neurobiol Dis, 62, 193 - 207
Stereological and ultrastructural quantification of the afferent synaptome of individual neurons
Journal article

Henny P. et al, (2014), Brain Structure and Function, 219, 631 - 640
Temporal coupling with cortex distinguishes spontaneous neuronal activities in identified basal ganglia-recipient and cerebellar-recipient zones of the motor thalamus.
Journal article

Nakamura KC. et al, (2014), Cereb Cortex, 24, 81 - 97

2013

Theme 1 Clinical

The Val158Met COMT polymorphism is a modifier of the age at onset in Parkinson's disease with a sexual dimorphism.
Journal article

Klebe S. et al, (2013), J Neurol Neurosurg Psychiatry, 84, 666 - 673

Theme 2 Cellular

A GAA repeat expansion reporter model of Friedreich's ataxia recapitulates the genomic context and allows rapid screening of therapeutic compounds.
Journal article

Lufino MMP. et al, (2013), Hum Mol Genet, 22, 5173 - 5187
Induced pluripotent stem cell (iPSC)-derived dopaminergic models of Parkinson's disease.
Journal article

Beevers JE. et al, (2013), Biochem Soc Trans, 41, 1503 - 1508
Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model.
Journal article

Janezic S. et al, (2013), Proc Natl Acad Sci U S A, 110, E4016 - E4025
RNA dysfunction and aggrephagy at the centre of an amyotrophic lateral sclerosis/frontotemporal dementia disease continuum.
Journal article

Thomas M. et al, (2013), Brain, 136, 1345 - 1360
Detection and isolation of human serum autoantibodies that recognize oxidatively modified autoantigens.
Journal article

Eggleton P. et al, (2013), Free Radic Biol Med, 57, 79 - 91
HSV-1 AMPLICON MEDIATED DELIVERY OF THE HUMAN beta-GLOBIN LOCUS
Conference paper

McColl B. et al, (2013), JOURNAL OF GENE MEDICINE, 15, 337 - 337

Theme 3 Models

Nicotinic acetylcholine receptor regulation of striatal dopamine transmission: The different requirement for diverse subtypes in ventral versus dorsal striatum
Conference paper

Exley R. et al, (2013), BIOCHEMICAL PHARMACOLOGY, 86, 1228 - 1229
Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model.
Journal article

Janezic S. et al, (2013), Proc Natl Acad Sci U S A, 110, E4016 - E4025
Striatal dopamine transmission is reduced after chronic nicotine with a decrease in α6-nicotinic receptor control in nucleus accumbens.
Journal article

Exley R. et al, (2013), Eur J Neurosci, 38, 3036 - 3043
Serotonin spillover onto the axon initial segment of motoneurons induces central fatigue by inhibiting action potential initiation.
Journal article

Cotel F. et al, (2013), Proc Natl Acad Sci U S A, 110, 4774 - 4779

2012

Theme 1 Clinical

Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease.
Journal article

Keller MF. et al, (2012), Hum Mol Genet, 21, 4996 - 5009

Theme 2 Cellular

Insights into LRRK2 function and dysfunction from transgenic and knockout rodent models.
Journal article

Sloan M. et al, (2012), Biochem Soc Trans, 40, 1080 - 1085
Cellular reprogramming: a new approach to modelling Parkinson's disease.
Journal article

Hartfield EM. et al, (2012), Biochem Soc Trans, 40, 1152 - 1157
Genetics: The MAPT locus-a genetic paradigm in disease susceptibility.
Journal article

Wade-Martins R., (2012), Nat Rev Neurol, 8, 477 - 478
The role of MAPT sequence variation in mechanisms of disease susceptibility.
Journal article

Caffrey TM. and Wade-Martins R., (2012), Biochem Soc Trans, 40, 687 - 692
Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus.
Journal article

Hamilton G. et al, (2012), Neurobiol Aging, 33, 1848.e1 - 1848.13
Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus
Journal article

Hamilton G. et al, (2012), Neurobiology of Aging, 33, 1848.e1 - 1848.e13
Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus.
Journal article

Hamilton G. et al, (2012), Neurobiology of aging, 33
Guidelines for the use and interpretation of assays for monitoring autophagy.
Journal article

Klionsky DJ. et al, (2012), Autophagy, 8, 445 - 544
A novel method for autophagy detection in primary cells: impaired levels of macroautophagy in immunosenescent T cells.
Journal article

Phadwal K. et al, (2012), Autophagy, 8, 677 - 689
RNAi-mediated knockdown of HMG CoA reductase enhances gene expression from physiologically regulated low-density lipoprotein receptor therapeutic vectors in vivo.
Journal article

Hibbitt O. et al, (2012), Gene Ther, 19, 463 - 467
RNAi-mediated knockdown of HMG CoA reductase enhances gene expression from physiologically regulated low-density lipoprotein receptor therapeutic vectors in vivo
Journal article

Hibbitt O. et al, (2012), Gene Therapy, 19, 463 - 467
Dissecting the Role of FUS Mutations on Subcellular Protein Localisation and Function Using a Novel Genomic Expression System
Conference paper

Thomas M. et al, (2012), DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 33, 66 - 67
Mitochondrial bioenergetics in a cell culture model of Parkinson's disease
Journal article

Ryan BJ. et al, (2012), FREE RADICAL BIOLOGY AND MEDICINE, 53, S178 - S178
Measurement of serum autoantibodies against oxidatively modified autoantigens in human autoimmune diseases
Journal article

Winyard PG. et al, (2012), FREE RADICAL BIOLOGY AND MEDICINE, 53, S64 - S65

Theme 3 Models

Relationships between the firing of identified striatal interneurons and spontaneous and driven cortical activities in vivo.
Journal article

Sharott A. et al, (2012), J Neurosci, 32, 13221 - 13236
K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration.
Journal article

Schiemann J. et al, (2012), Nat Neurosci, 15, 1272 - 1280
Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons.
Journal article

Threlfell S. et al, (2012), Neuron, 75, 58 - 64
Cell-type-specific recruitment of amygdala interneurons to hippocampal theta rhythm and noxious stimuli in vivo.
Journal article

Bienvenu TCM. et al, (2012), Neuron, 74, 1059 - 1074
Dichotomous organization of the external globus pallidus.
Journal article

Mallet N. et al, (2012), Neuron, 74, 1075 - 1086
Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin.
Journal article

Adlam D. et al, (2012), Cardiovasc Res, 93, 694 - 701
Frequency selectivity and dopamine-dependence of plasticity at glutamatergic synapses in the subthalamic nucleus.
Journal article

Yamawaki N. et al, (2012), Neuroscience, 203, 1 - 11
Striatal α5 nicotinic receptor subunit regulates dopamine transmission in dorsal striatum.
Journal article

Exley R. et al, (2012), J Neurosci, 32, 2352 - 2356
Structural correlates of heterogeneous in vivo activity of midbrain dopaminergic neurons.
Journal article

Henny P. et al, (2012), Nat Neurosci, 15, 613 - 619
Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin
Journal article

Adlam D. et al, (2012), Cardiovascular Research, 93, 694 - 701
Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice.
Journal article

Platt NJ. et al, (2012), PLoS One, 7
Striatal Acetylcholine-Dopamine Crosstalk and the Dorsal-Ventral Divide
Chapter

Threlfell S. and Cragg SJ., (2012), DOPAMINE-GLUTAMATE INTERACTIONS IN THE BASAL GANGLIA, 119 - 138

2011

Theme 1 Clinical

How well do we recognise non-motor symptoms in a British Parkinson's disease population?
Journal article

Hu M. et al, (2011), J Neurol, 258, 1513 - 1517
A two-stage meta-analysis identifies several new loci for Parkinson's disease.
Journal article

International Parkinson's Disease Genomics Consortium (IPDGC) None. and Wellcome Trust Case Control Consortium 2 (WTCCC2) None., (2011), PLoS Genet, 7
How common and what are the determinants of sub-optimal care for Parkinson's disease patients: the Milton Keynes community study.
Journal article

Hu MTM. et al, (2011), Parkinsonism Relat Disord, 17, 177 - 181
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.
Journal article

International Parkinson Disease Genomics Consortium None. et al, (2011), Lancet, 377, 641 - 649

Theme 2 Cellular

Combining M-FISH and Quantum Dot technology for fast chromosomal assignment of transgenic insertions.
Journal article

Yusuf M. et al, (2011), BMC Biotechnol, 11
Infectious delivery and long-term persistence of transgene expression in the brain by a 135-kb iBAC-FXN genomic DNA expression vector.
Journal article

Gimenez-Cassina A. et al, (2011), Gene Ther, 18, 1015 - 1019
Infectious delivery and long-term persistence of transgene expression in the brain by a 135-kb iBAC-FXN genomic DNA expression vector
Journal article

Gimenez-Cassina A. et al, (2011), Gene Therapy, 18, 1015 - 1019
Measurement and meaning of markers of reactive species of oxygen, nitrogen and sulfur in healthy human subjects and patients with inflammatory joint disease.
Journal article

Winyard PG. et al, (2011), Biochem Soc Trans, 39, 1226 - 1232
A BACwards glance at neurodegeneration: molecular insights into disease from LRRK2, SNCA and MAPT BAC-transgenic mice.
Journal article

Johnson SJ. and Wade-Martins R., (2011), Biochem Soc Trans, 39, 862 - 867
Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family.
Journal article

Anwar S. et al, (2011), J Neurosci, 31, 7264 - 7274
Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation.
Journal article

Shipton OA. et al, (2011), J Neurosci, 31, 1688 - 1692
Developing extrachromosomal gene expression vector technologies: an overview.
Journal article

Wade-Martins R., (2011), Methods Mol Biol, 738, 1 - 17
Episomal transgene expression in pluripotent stem cells.
Journal article

Lufino MMP. et al, (2011), Methods Mol Biol, 767, 369 - 387
High capacity extrachromosomal gene expression vectors.
Journal article

Hibbitt O. and Wade-Martins R., (2011), Methods Mol Biol, 738, 19 - 40
POST-TRANSLATIONAL MODIFICATIONS OF C1Q LEAD TO ANTIGENICITY AND BREAKDOWN OF IMMUNE TOLERANCE IN SYSTEMIC LUPUS ERYTHEMATOSUS
Journal article

Eggleton P. et al, (2011), CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 29, 176 - 176

Theme 3 Models

Dopamine release in the basal ganglia.
Journal article

Rice ME. et al, (2011), Neuroscience, 198, 112 - 137
Dopamine release in the basal ganglia
Journal article

Rice ME. et al, (2011), Neuroscience, 198, 112 - 137
Morphological characterization of large intercalated neurons provides novel insight on intrinsic networks of the amygdala
Journal article

Busti D. et al, (2011), BMC Pharmacology, 11
Effects of dopamine depletion on information flow between the subthalamic nucleus and external globus pallidus.
Journal article

Cruz AV. et al, (2011), J Neurophysiol, 106, 2012 - 2023
Nitric oxide donors enhance the frequency dependence of dopamine release in nucleus accumbens.
Journal article

Hartung H. et al, (2011), Neuropsychopharmacology, 36, 1811 - 1822
Nitric oxide donors enhance the frequency dependence of dopamine release in nucleus accumbens
Journal article

Hartung H. et al, (2011), Neuropsychopharmacology, 36, 1811 - 1822
Alterations in brain connectivity underlying beta oscillations in Parkinsonism.
Journal article

Moran RJ. et al, (2011), PLoS Comput Biol, 7
Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family.
Journal article

Anwar S. et al, (2011), J Neurosci, 31, 7264 - 7274
Distinct contributions of nicotinic acetylcholine receptor subunit alpha4 and subunit alpha6 to the reinforcing effects of nicotine.
Journal article

Exley R. et al, (2011), Proc Natl Acad Sci U S A, 108, 7577 - 7582
Dopamine signaling in dorsal versus ventral striatum: The dynamic role of cholinergic interneurons
Journal article

Threlfell S. and Cragg SJ., (2011), Frontiers in Systems Neuroscience
Dopamine signaling in dorsal versus ventral striatum: the dynamic role of cholinergic interneurons.
Journal article

Threlfell S. and Cragg SJ., (2011), Front Syst Neurosci, 5

2010

Theme 1: Clinical

Theme 2 Cellular

α-Synuclein and dopamine at the crossroads of Parkinson's disease.
Journal article

Venda LL. et al, (2010), Trends Neurosci, 33, 559 - 568
Extracellular calreticulin is present in the joints of patients with rheumatoid arthritis and inhibits FasL (CD95L)-mediated apoptosis of T cells.
Journal article

Tarr JM. et al, (2010), Arthritis Rheum, 62, 2919 - 2929
Long-term physiologically regulated expression of the low-density lipoprotein receptor in vivo using genomic DNA mini-gene constructs.
Journal article

Hibbitt OC. et al, (2010), Mol Ther, 18, 317 - 326
A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors.
Journal article

Evers B. et al, (2010), Clin Cancer Res, 16, 99 - 108
Targeted Gene Knockdown of HMG CoA Reductase Increases Transgene Expression from Genomic DNA LDLR Mini-Gene Vectors In Vitro and In Vivo: Increased Transgene Expression from Genomic LDLR Mini-Gene Vectors In Vitro and In Vivo Following Targeted Knockdown of HMG CoA Reductase
Conference paper

Hibbitt OC. et al, (2010), HUMAN GENE THERAPY, 21, 505 - 505
UNDERSTANDING THE EARLY PATHOLOGICAL PATHWAYS IN PARKINSON'S DISEASE. THE OXFORD PARKINSON'S DISEASE CENTRE
Conference paper

Hu M. et al, (2010), JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 81, E59 - E59
Oxidative and Nitrative Modification of C1q Affects its Structure, Function and Antigenicity in Systemic Lupus Erythematosus
Conference paper

Ryan B. et al, (2010), FREE RADICAL BIOLOGY AND MEDICINE, 49, S148 - S148

Theme 3 Models

α-Synuclein and dopamine at the crossroads of Parkinson's disease.
Journal article

Venda LL. et al, (2010), Trends Neurosci, 33, 559 - 568
Non-linear relationship between 5-HT transporter gene expression and frequency sensitivity of 5-HT signals.
Journal article

Jennings KA. et al, (2010), J Neurochem, 115, 965 - 973
Distinct types of non-cholinergic pedunculopontine neurons are differentially modulated during global brain states.
Journal article

Ros H. et al, (2010), Neuroscience, 170, 78 - 91
Striatal muscarinic receptors promote activity dependence of dopamine transmission via distinct receptor subtypes on cholinergic interneurons in ventral versus dorsal striatum.
Journal article

Threlfell S. et al, (2010), J Neurosci, 30, 3398 - 3408
5-HT(1B) receptor regulation of serotonin (5-HT) release by endogenous 5-HT in the substantia nigra.
Journal article

Threlfell S. et al, (2010), Neuroscience, 165, 212 - 220