OPDC Publications

Mitochondrial Dysfunction and Mitophagy in Parkinson's Disease

Cover image of Trends in Biochemical Sciences Volume 46, Number 4, April 2021

See the full issue

2025

Theme 1: Clinical

Dopamine and the dynamics of subthalamic and leg muscle activities in parkinsonian stepping.

Simpson TG. et al, (2025), Brain

Disentangling motor and cognitive roles of cortical beta oscillations and their modulation with rTMS

He S. et al, (2025)

Cortical and Corticomuscular Beta-Gamma Phase-Amplitude Coupling During Different Locomotion States and the Effects of Levodopa in Parkinson's Disease.

Zhao H. et al, (2025), Mov Disord, 40, 2641 - 2653

Quantitative measurements of α-synuclein seeds in CSF inform diagnosis of synucleinopathies.

Abdi IY. et al, (2025), J Parkinsons Dis, 15, 1412 - 1430

Smartphone-based prediction of dopaminergic deficit in prodromal and manifest Parkinson's disease.

Gunter KM. et al, (2025), NPJ Digit Med, 8

Biomarkers

Mak E. et al, (2025), Alzheimer S Dementia the Journal of the Alzheimer S Association, 21

Global network and local vulnerabilities underlie brain atrophy across Parkinson's disease stages.

Vo A. et al, (2025), Brain

Actigraphy-based detection of isolated REM sleep behavior disorder: multicenter validation across devices and populations.

Zhou L. et al, (2025), NPJ Digit Med, 8

Estrogen-related receptor gene expression associates with sex differences in cortical atrophy in isolated REM sleep behavior disorder.

Filiatrault M. et al, (2025), Nat Commun, 16

Association of DTI-ALPS Glymphatic Index With Differential Phenoconversion in Isolated REM Sleep Behavior Disorder: A Multi-Cohort MRI Study.

Ayral V. et al, (2025), Neurology, 105

More publications

Theme 2: Cellular

Protocol for pooled FACS-based CRISPR knockout screening in human iPSC-derived microglia.

Washer SJ. et al, (2025), STAR Protoc, 6

Aquaporins in GtoPdb v.2025.4

Bill RM. et al, (2025), IUPHAR/BPS Guide to Pharmacology CITE, 2025

The Concise Guide to PHARMACOLOGY 2025/26: Ion channels.

Alexander SPH. et al, (2025), Br J Pharmacol, 182 Suppl 1, S152 - S241

Basic Science and Pathogenesis

Bertherat F. et al, (2025), Alzheimer S Dementia the Journal of the Alzheimer S Association, 21

Cerebellar organoids model cell type-specific FOXP2 expression during human cerebellar development.

Apsley EJ. et al, (2025), Dis Model Mech, 18

Evidence for enhancer activity in intron 1 of TNFRSF1A using CRISPR/Cas9 in human induced pluripotent stem cell-derived macrophages.

Osgood JA. et al, (2025), Sci Rep, 15

Aquaporins in GtoPdb v.2025.3

Bill RM. et al, (2025), IUPHAR/BPS Guide to Pharmacology CITE, 2025

Galectin-3 induces neurodevelopmental apical-basal polarity and regulates gyrification.

Soares LC. et al, (2025), Sci Adv, 11

SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides.

Loreto A. et al, (2025), Neurobiol Dis, 213

Cytoskeletal control in adult microglia is essential to restore neurodevelopmental synaptic and cognitive deficits.

Kessels S. et al, (2025), Sci Adv, 11

More publications

Theme 3: Models

Nucleophagy removes cytotoxic trapped PARP1

Hoslett G. et al, (2025)

Loss of the lysosomal protein CLN3 triggers c-Abl-dependent YAP1 pro-apoptotic signaling.

Domingues N. et al, (2025), EMBO Rep, 26, 6096 - 6120

Adenosine in the Brain: Recent Progress on Detection, Function, and Translation.

Yahiro T. et al, (2025), J Neurosci, 45

TAAR1 Regulates Presynaptic Dopamine Function: Evidence From Preclinical Studies and a Phase 1b Trial in Patients With Schizophrenia.

Howes OD. et al, (2025), Biol Psychiatry

Large-scale visualization of α-synuclein oligomers in Parkinson's disease brain tissue.

Andrews R. et al, (2025), Nat Biomed Eng

New insights into axonal regulators of dopamine transmission in health and disease.

Todd KL. et al, (2025), Curr Opin Neurobiol, 94

Gabapentinoids promote striatal dopamine release and rescue multiple deficits of a mouse model of early Parkinson’s

Brimblecombe KR. et al, (2025)

The Handbook of Dopamine

(2025)

Intersectin and endophilin condensates prime synaptic vesicles for release site replenishment.

Ogunmowo TH. et al, (2025), Nat Neurosci, 28, 1649 - 1662

Dopamine D2 receptor upregulation in dorsal striatum in the LRRK2-R1441C rat model of early Parkinson's disease revealed by in vivo PET imaging.

Delgado-Goñi T. et al, (2025), Sci Rep, 15

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2024

Theme 1: Clinical

Abundant non-inclusion α-synuclein pathology in Lewy body-negative LRRK2-mutant cases

Jensen NM. et al, (2024)

Revolutionizing treatment for disorders of consciousness: a multidisciplinary review of advancements in deep brain stimulation.

Yang Y. et al, (2024), Mil Med Res, 11

Evaluation of Cerebrospinal Fluid α-Synuclein Seed Amplification Assay in Progressive Supranuclear Palsy and Corticobasal Syndrome.

Vaughan DP. et al, (2024), Mov Disord, 39, 2285 - 2291

Unraveling Microglial Spatial Organization in the Developing Human Brain with DeepCellMap, a Deep Learning Approach Coupled to Spatial Statistics

Perochon T. et al, (2024)

Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profiles.

Lee SS. et al, (2024)

Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profiles

Lee SS. et al, (2024), eLife, 13

Rapid modulation of striatal cholinergic interneurons and dopamine release by satellite astrocytes.

Stedehouder J. et al, (2024), Nat Commun, 15

A worldwide study of subcortical shape as a marker for clinical staging in Parkinson's disease.

Laansma MA. et al, (2024), NPJ Parkinsons Dis, 10

Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profiles

Lee SS. et al, (2024)

Cortico-thalamic tremor circuits and their associations with deep brain stimulation effects in essential tremor

He S. et al, (2024)

More publications

Theme 2: Cellular

Cerebellar organoids model cell type-specific FOXP2 expression during human cerebellar development

Apsley EJ. et al, (2024)

Benchmarking nanopore sequencing and rapid genomics feasibility: validation at a quaternary hospital in New Zealand.

Nyaga DM. et al, (2024), NPJ Genom Med, 9

Optical genome mapping of structural variants in Parkinson's disease-related induced pluripotent stem cells.

Trinh J. et al, (2024), BMC Genomics, 25

Tapasin assembly surveillance by the RNF185/Membralin ubiquitin ligase complex regulates MHC-I surface expression.

van de Weijer ML. et al, (2024), Nat Commun, 15

Variant-specific effects of GBA1 mutations on dopaminergic neuron proteostasis.

Onal G. et al, (2024), J Neurochem, 168, 2543 - 2560

Astrocytes in functional recovery following central nervous system injuries.

Alhadidi QM. et al, (2024), J Physiol, 602, 3069 - 3096

Tau depletion in human neurons mitigates Aβ-driven toxicity.

Ng B. et al, (2024), Mol Psychiatry, 29, 2009 - 2020

A fluid-walled microfluidic platform for human neuron microcircuits and directed axotomy.

Nebuloni F. et al, (2024), Lab Chip, 24, 3252 - 3264

TransLeish: Identification of membrane transporters essential for survival of intracellular Leishmania parasites in a systematic gene deletion screen

Albuquerque-Wendt A. et al, (2024)

Systematic identification of structure-specific protein-protein interactions.

Holfeld A. et al, (2024), Mol Syst Biol, 20, 651 - 675

More publications

Theme 3: Models

Rapid modulation of striatal cholinergic interneurons and dopamine release by satellite astrocytes.

Stedehouder J. et al, (2024), Nat Commun, 15

Impaired striatal glutathione-ascorbate metabolism induces transient dopamine increase and motor dysfunction.

Malik MY. et al, (2024), Nat Metab, 6, 2100 - 2117

Beta bursts in the parkinsonian cortico-basal ganglia network form spatially discrete ensembles.

Grennan I. et al, (2024), Neurobiol Dis, 201

TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival.

Lascaux P. et al, (2024), Cell, 187, 5698 - 5718.e26

Connexin43 promotes exocytosis of damaged lysosomes through actin remodelling.

Domingues N. et al, (2024), EMBO J, 43, 3627 - 3649

Upregulation of cholesterol synthesis by lysosomal defects requires a functional mitochondrial respiratory chain.

Agostini F. et al, (2024), J Biol Chem, 300

Loss of the lysosomal protein CLN3 modifies the lipid content of the nuclear envelope leading to DNA damage and activation of YAP1 pro-apoptotic signaling.

Domingues N. et al, (2024)

Distributional coding of associative learning in discrete populations of midbrain dopamine neurons.

Avvisati R. et al, (2024), Cell Rep, 43

Up-regulation of cholesterol synthesis by lysosomal defects requires a functional mitochondrial respiratory chain.

Agostini F. et al, (2024), bioRxiv

Dopamine transmission in the tail striatum: Regional variation and contribution of dopamine clearance mechanisms.

Riley B. et al, (2024), J Neurochem, 168, 251 - 268

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2023

Theme 1: Clinical

Author Correction: Accurate long-read sequencing identified GBA1 as major risk factor in the Luxembourgish Parkinson's study.

Pachchek S. et al, (2023), NPJ Parkinsons Dis, 9

Protocol for tissue processing and paraffin embedding of mouse brains following ex vivo MRI.

Smart A. et al, (2023), STAR Protoc, 4

Development and validation of an expanded antibody toolset that captures alpha-synuclein pathological diversity in Lewy body diseases.

Altay MF. et al, (2023), NPJ Parkinsons Dis, 9

Beta-triggered adaptive deep brain stimulation during reaching movement in Parkinson's disease.

He S. et al, (2023), Brain, 146, 5015 - 5030

Normal and pathogenic variation of RFC1 repeat expansions: implications for clinical diagnosis.

Dominik N. et al, (2023), Brain, 146, 5060 - 5069

Deep topographic proteomics of a human brain tumour.

Davis S. et al, (2023), Nat Commun, 14

Accurate long-read sequencing identified GBA1 as major risk factor in the Luxembourgish Parkinson's study.

Pachchek S. et al, (2023), NPJ Parkinsons Dis, 9

Investigating gait-responsive somatosensory cueing from a wearable device to improve walking in Parkinson's disease.

Li D. et al, (2023), Biomed Eng Online, 22

Tuning the brakes – Modulatory role of transcranial random noise stimulation on inhibition

Mandali A. et al, (2023)

Methodological considerations in neuronal extracellular vesicle isolation for α-synuclein biomarkers.

Yan S. et al, (2023), Brain, 146, e95 - e97

More publications

Theme 2: Cellular

Correction: Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons.

Hasan S. et al, (2023), Mol Neurodegener, 18

Transcriptional memory is conferred by combined heritable maintenance and local removal of selective chromatin modifications

Mikulski P. et al, (2023)

Aquaporins in GtoPdb v.2023.3

Bill RM. et al, (2023), IUPHAR/BPS Guide to Pharmacology CITE, 2023

Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons.

Hasan S. et al, (2023), Mol Neurodegener, 18

Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson’s

BRIMBLECOMBE K. et al, (2023), European Journal of Neuroscience

A fluid-walled microfluidic platform for human neuron microcircuits and directed axotomy

Nebuloni F. et al, (2023)

Integration of 3D-printed cerebral cortical tissue into an ex vivo lesioned brain slice.

Jin Y. et al, (2023), Nat Commun, 14

The Concise Guide to PHARMACOLOGY 2023/24: Ion channels.

Alexander SPH. et al, (2023), Br J Pharmacol, 180 Suppl 2, S145 - S222

C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9.

Vahsen BF. et al, (2023), Nat Commun, 14

Patient-derived iPSC models of Friedreich ataxia: a new frontier for understanding disease mechanisms and therapeutic application.

Maheshwari S. et al, (2023), Transl Neurodegener, 12

More publications

Theme 3: Models

Lights, Fiber, Action! A primer on in vivo fiber photometry

WALTON M. et al, (2023), Neuron

Axo-glial interactions between midbrain dopamine neurons and oligodendrocyte lineage cells in the anterior corpus callosum.

Caldwell M. et al, (2023), Brain Struct Funct, 228, 1993 - 2006

MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress

Carvalho AL. et al, (2023)

Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson’s

BRIMBLECOMBE K. et al, (2023), European Journal of Neuroscience

Discovery of CVN417, a Novel Brain-Penetrant α6-Containing Nicotinic Receptor Antagonist for the Modulation of Motor Dysfunction.

Christie LA. et al, (2023), J Med Chem, 66, 11718 - 11731

Intersectin and Endophilin condensates prime synaptic vesicles for release site replenishment.

Ogunmowo T. et al, (2023), bioRxiv

Impaired dopamine release in Parkinson's disease.

Cramb KML. et al, (2023), Brain, 146, 3117 - 3132

A Selective Projection from the Subthalamic Nucleus to Parvalbumin-Expressing Interneurons of the Striatum.

Kondabolu K. et al, (2023), eNeuro, 10

The aperiodic exponent of subthalamic field potentials reflects excitation/inhibition balance in Parkinsonism.

Wiest C. et al, (2023), Elife, 12

Theme 1: Clinical

Theme 2: Cellular

Theme 3: Models

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OPDC Publications

Mitochondrial Dysfunction and Mitophagy in Parkinson's Disease

2025

Theme 1: Clinical

Theme 2: Cellular

Theme 3: Models

2024

Theme 1: Clinical

Theme 2: Cellular

Theme 3: Models

2023

Theme 1: Clinical

Theme 2: Cellular

Theme 3: Models

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