OPDC Publications

Mitochondrial Dysfunction and Mitophagy in Parkinson's Disease

Cover image of Trends in Biochemical Sciences Volume 46, Number 4, April 2021

See the full issue

Theme 1: Clinical

Genetic associations between post-traumatic stress disorder and REM-sleep behavior disorder

Ghamgosar Shahkhali M. et al, (2026), Npj Parkinson S Disease, 12

α-Synuclein blocks endoplasmic reticulum co-translational protein translocation early in Parkinson’s disease

Lam CL. et al, (2026), Nature Communications, 17

GWAS on short tandem repeats identifies genetic mechanisms in Alzheimer’s disease

Gmelin D. et al, (2026), Nature Communications, 17

Suppression of pathological oscillations with transcranial focused ultrasound in Parkinson’s disease

Eraifej J. et al, (2026), Nature Communications, 17

Data-driven trajectories of atrophy explain clinical heterogeneity across Lewy body diseases

Konuri A. et al, (2026), Ebiomedicine, 131

Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profiles

Lee SS. et al, (2026)

Defining the underlying pathology of corticobasal syndrome using clinical features and biomarkers.

Vaughan DP. et al, (2026), Brain

Patient experiences of tissue donation and digital consent support in primary craniospinal tumour research

Mawhinney G. et al, (2026), Supportive Care in Cancer, 34

‘A No-Brainer, but Not a Simple Decision’: A Qualitative Study of Patient Experiences of Tissue Donation for Research in Rare Craniospinal Tumour Pathways

Mawhinney G. et al, (2026), Health Expectations, 29

Early assessment, diagnosis and treatment of Parkinsonism and Related Syndromes study (ExPRESS): a protocol for an observational study on incident parkinsonism

Fumi RG. et al, (2026), BMJ Open, 16

More publications

Theme 2: Cellular

Protocol for efficient purification of endotoxin-free human recombinant tau protein

Karabova MK. et al, (2026), STAR Protocols, 7, 104800 - 104800

Varicose projection astrocytes: Conserved reactive cells in brain pathology

Ciani C. et al, (2026), Science Advances, 12, 1 - 18

Dissecting genotype-specific effects of disease-associated genetic variants

Farrow SL. et al, (2026), Iscience, 29

Reactive astrocytes mediate toxicity in iPSC derived dopaminergic neurons.

Ibarra-Aizpurua N. et al, (2026), NPJ Parkinsons Dis

Single-cell and spatial transcriptomic analyses of gene therapy-associated retinal inflammation in non-human primates.

Sourd C. et al, (2026), Mol Ther Adv, 34

Phosphorylated ubiquitin is a secondary messenger and an epigenetic mark mediating mitochondria to nucleus signaling.

Mercer TJ. et al, (2026)

Tracking tau and cellular responses in human iPSC-microglia: from uptake to seedable secretion, including in extracellular vesicles

Karabova MK. et al, (2026), Alzheimer S and Dementia, 22

Dopamine release from Parkinson’s patient-derived neurons is disrupted due to impaired synaptic vesicle loading

Cramb KML. et al, (2026)

CHCHD2 links mitochondrial dysfunction and α-synuclein misfolding in Parkinson’s disease

Narendra D. and Ryan BJ., (2026), Trends in Neurosciences, 49, 157 - 158

Light-driven repair: Photobiomodulation restores blood–brain barrier function following hypoxic injury

Domocos M. et al, (2026)

More publications

Theme 3: Models

The superior colliculus gates dopamine responses to conditioned stimuli in visual classical conditioning

Zhang YF. et al, (2026), Nature Communications, 17

Dynamins maintain nuclear envelope homeostasis and genome stability

Aveleira C. et al, (2026), Nature Communications, 17

Selective GRAB sensors reveal distinct endocannabinoid dynamics in vivo

Cai R. et al, (2026)

5-HT4 Receptor Ligand RS67333 Modulates Striatal Acetylcholine and Dopamine Release via the Inhibition of Acetylcholinesterase

Qiao Q. et al, (2026), ACS Chemical Neuroscience, 17, 3013 - 3022

Dopamine release from Parkinson’s patient-derived neurons is disrupted due to impaired synaptic vesicle loading

Cramb KML. et al, (2026)

Corrigendum to "New insights into axonal regulators of dopamine transmission in health and disease" [Curr Op Neurobiol 94 (2025) 103093

Todd KL. et al, (2026), Current Opinion in Neurobiology, 96

An anatomical hotspot for striatal dopamine-acetylcholine interactions during reward and movement.

Bouabid S. et al, (2026), bioRxiv

Dopamine neurotransmission in Parkinson's disease

Cramb KML. et al, (2026), 35, 171 - 189

Nucleophagy removes cytotoxic trapped PARP1

Hoslett G. et al, (2026), Nature Cell Biology

TAAR1 Regulates Presynaptic Dopamine Function: Evidence From Preclinical Studies and a Phase 1b Trial in Patients With Schizophrenia

Howes OD. et al, (2026), Biological Psychiatry

More publications

2025

Theme 1: Clinical

Dopamine and the dynamics of subthalamic and leg muscle activities in parkinsonian stepping.

Simpson TG. et al, (2025), Brain

Genome-wide association study of REM sleep behavior disorder in Parkinson’s disease

Sosero YL. et al, (2025), Npj Parkinson S Disease, 11

Dopamine D2 receptor upregulation in dorsal striatum in the LRRK2-R1441C rat model of early Parkinson’s disease revealed by in vivo PET imaging

Delgado-Goñi T. et al, (2025), Scientific Reports, 15

The profile of gastrointestinal dysfunction in prodromal to late-stage Parkinson’s disease

Camacho M. et al, (2025), npj Parkinson's Disease, 11

Working memory filtering at encoding and maintenance in healthy ageing, Alzheimer’s and Parkinson’s disease

Toniolo S. et al, (2025), Scientific Reports, 15

Smartphone-based prediction of dopaminergic deficit in prodromal and manifest Parkinson’s disease

Gunter KM. et al, (2025), Npj Digital Medicine, 8

Actigraphy-based detection of isolated REM sleep behavior disorder: multicenter validation across devices and populations

Zhou L. et al, (2025), Npj Digital Medicine, 8

Study protocol for putting the ‘Person’ in the PiCTuRE: an exploratory sequential mixed methods-based design, exploring how precision medicine is implemented and experienced by people living with a primary tumour of the craniospinal axis

Mawhinney G. et al, (2025), BMC Cancer, 25

Biomarkers

Mak E. et al, (2025), Alzheimer S Dementia the Journal of the Alzheimer S Association, 21

Quantitative measurements of α-synuclein seeds in CSF inform diagnosis of synucleinopathies

Abdi IY. et al, (2025), Journal of Parkinson S Disease, 15, 1412 - 1430

More publications

Theme 2: Cellular

Protocol for pooled FACS-based CRISPR knockout screening in human iPSC-derived microglia

Washer SJ. et al, (2025), STAR Protocols, 6

Aquaporins in GtoPdb v.2025.4

Bill RM. et al, (2025), IUPHAR/BPS Guide to Pharmacology CITE, 2025

TransLeish: Identification of membrane transporters essential for survival of intracellular Leishmania parasites in a systematic gene deletion screen

Albuquerque-Wendt A. et al, (2025), Nature Communications, 16

Basic Science and Pathogenesis

Bertherat F. et al, (2025), Alzheimer S Dementia the Journal of the Alzheimer S Association, 21

The Concise Guide to PHARMACOLOGY 2025/26: Ion channels

Alexander SPH. et al, (2025), British Journal of Pharmacology, 182, S152 - S241

Formation of seeding-competent α-synuclein aggregates in parkin-deficient iPSC-derived human neurons

Schmidt SI. et al, (2025), Npj Parkinson S Disease, 11

Cerebellar organoids model cell type-specific FOXP2 expression during human cerebellar development

Apsley EJ. et al, (2025), Disease Models Mechanisms, 18

Evidence for enhancer activity in intron 1 of TNFRSF1A using CRISPR/Cas9 in human induced pluripotent stem cell-derived macrophages

Osgood JA. et al, (2025), Scientific Reports, 15

Aquaporins in GtoPdb v.2025.3

Bill RM. et al, (2025), IUPHAR/BPS Guide to Pharmacology CITE, 2025

Galectin-3 induces neurodevelopmental apical-basal polarity and regulates gyrification

Soares LC. et al, (2025), Science Advances, 11

More publications

Theme 3: Models

Dopamine D2 receptor upregulation in dorsal striatum in the LRRK2-R1441C rat model of early Parkinson’s disease revealed by in vivo PET imaging

Delgado-Goñi T. et al, (2025), Scientific Reports, 15

Adenosine in the Brain: Recent Progress on Detection, Function, and Translation

Yahiro T. et al, (2025), Journal of Neuroscience the Official Journal of the Society for Neuroscience, 45

TAAR1 Regulates Presynaptic Dopamine Function: Evidence From Preclinical Studies and a Phase 1b Trial in Patients With Schizophrenia.

Howes OD. et al, (2025), Biol Psychiatry

New insights into axonal regulators of dopamine transmission in health and disease

Todd KL. et al, (2025), Current Opinion in Neurobiology, 94

The Handbook of Dopamine

(2025)

MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress

Rodrigues B. et al, (2025), Molecular Psychiatry, 30, 1034 - 1046

Somatodendritic Dopamine Release in Midbrain

Cragg SJ. and Rice ME., (2025), 69 - 83

Intersectin and endophilin condensates prime synaptic vesicles for release site replenishment

Ogunmowo TH. et al, (2025), Nature Neuroscience

Role of lipids in interorganelle communication

Domingues N. et al, (2025), Trends in Cell Biology, 35, 46 - 58

Loss of the lysosomal protein CLN3 triggers c-Abl-dependent YAP1 pro-apoptotic signaling

Domingues N. et al, (2025), EMBO Reports

More publications

2024

Theme 1: Clinical

Comprehensive blood metabolomics profiling of Parkinson’s disease reveals coordinated alterations in xanthine metabolism

de Lope EG. et al, (2024), Npj Parkinson S Disease, 10

Predictors of short-term anxiety outcome in subthalamic stimulation for Parkinson’s disease

Sauerbier A. et al, (2024), npj Parkinson's Disease, 10

Rapid modulation of striatal cholinergic interneurons and dopamine release by satellite astrocytes

Stedehouder J. et al, (2024), Nature Communications, 15

A worldwide study of white matter microstructural alterations in people living with Parkinson’s disease

Owens-Walton C. et al, (2024), npj Parkinson's Disease, 10

Evaluation of Cerebrospinal Fluid α-Synuclein Seed Amplification Assay in Progressive Supranuclear Palsy and Corticobasal Syndrome

Vaughan DP. et al, (2024), Movement Disorders, 39, 2285 - 2291

Online cognitive monitoring technology for people with Parkinson’s disease and REM sleep behavioural disorder

Bălăeţ M. et al, (2024), npj Digital Medicine, 7

Genome-wide determinants of mortality and motor progression in Parkinson’s disease

Tan MMX. et al, (2024), npj Parkinson's Disease, 10

Author Correction: Development and validation of an expanded antibody toolset that captures alpha-synuclein pathological diversity in Lewy body diseases (npj Parkinson's Disease, (2023), 9, 1, (161), 10.1038/s41531-023-00604-y)

Altay MF. et al, (2024), Npj Parkinson S Disease, 10

A worldwide study of subcortical shape as a marker for clinical staging in Parkinson’s disease

Laansma MA. et al, (2024), npj Parkinson's Disease, 10

Revolutionizing treatment for disorders of consciousness: a multidisciplinary review of advancements in deep brain stimulation

Yang Y. et al, (2024), Military Medical Research, 11

More publications

Theme 2: Cellular

Tapasin assembly surveillance by the RNF185/Membralin ubiquitin ligase complex regulates MHC-I surface expression

van de Weijer ML. et al, (2024), Nature Communications, 15

Benchmarking nanopore sequencing and rapid genomics feasibility: validation at a quaternary hospital in New Zealand

Nyaga DM. et al, (2024), Npj Genomic Medicine, 9

Identification of 27 allele-specific regulatory variants in Parkinson’s disease using a massively parallel reporter assay

Farrow SL. et al, (2024), Npj Parkinson S Disease, 10

Early deficits in an in vitro striatal microcircuit model carrying the Parkinson’s GBA-N370S mutation

Do QB. et al, (2024), Npj Parkinson S Disease, 10

Discovering genetic mechanisms underlying the co-occurrence of Parkinson’s disease and non-motor traits

Gokuladhas S. et al, (2024), Npj Parkinson S Disease, 10

Optical genome mapping of structural variants in Parkinson’s disease-related induced pluripotent stem cells

Trinh J. et al, (2024), BMC Genomics, 25

Variant-specific effects of GBA1 mutations on dopaminergic neuron proteostasis

Onal G. et al, (2024), Journal of Neurochemistry, 168, 2543 - 2560

Tau depletion in human neurons mitigates Aβ-driven toxicity

Ng B. et al, (2024), Molecular Psychiatry, 29, 2009 - 2020

Astrocytes in functional recovery following central nervous system injuries

Alhadidi QM. et al, (2024), Journal of Physiology, 602, 3069 - 3096

A fluid-walled microfluidic platform for human neuron microcircuits and directed axotomy

Nebuloni F. et al, (2024), Lab on a Chip, 24, 3252 - 3264

More publications

Theme 3: Models

Rapid modulation of striatal cholinergic interneurons and dopamine release by satellite astrocytes

Stedehouder J. et al, (2024), Nature Communications, 15

Impaired striatal glutathione–ascorbate metabolism induces transient dopamine increase and motor dysfunction

Malik MY. et al, (2024), Nature Metabolism, 6, 2100 - 2117

Beta bursts in the parkinsonian cortico-basal ganglia network form spatially discrete ensembles

Grennan I. et al, (2024), Neurobiology of Disease, 201

TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival

Lascaux P. et al, (2024), Cell, 187, 5698 - 5718.e26

MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress

Rodrigues B. et al, (2024), Molecular Psychiatry, 30, 1034 - 1046

Connexin43 promotes exocytosis of damaged lysosomes through actin remodelling

Domingues N. et al, (2024), EMBO Journal, 43, 3627 - 3649

Upregulation of cholesterol synthesis by lysosomal defects requires a functional mitochondrial respiratory chain

Agostini F. et al, (2024), Journal of Biological Chemistry, 300

Loss of the lysosomal protein CLN3 modifies the lipid content of the nuclear envelope leading to DNA damage and activation of YAP1 pro-apoptotic signaling.

Domingues N. et al, (2024)

Distributional coding of associative learning in discrete populations of midbrain dopamine neurons

Avvisati R. et al, (2024), Cell Reports, 43

Up-regulation of cholesterol synthesis by lysosomal defects requires a functional mitochondrial respiratory chain.

Agostini F. et al, (2024), bioRxiv

More publications

2023

Theme 1: Clinical

Protocol for tissue processing and paraffin embedding of mouse brains following ex vivo MRI

Smart A. et al, (2023), STAR Protocols, 4

Neuronally derived extracellular vesicle α-synuclein as a serum biomarker for individuals at risk of developing Parkinson disease

Yan S. et al, (2023), JAMA Neurology, 81, 59 - 68

Development and validation of an expanded antibody toolset that captures alpha-synuclein pathological diversity in Lewy body diseases

Altay MF. et al, (2023), Npj Parkinson S Disease, 9

Deep topographic proteomics of a human brain tumour

Davis S. et al, (2023), Nature Communications, 14

Accurate long-read sequencing identified GBA1 as major risk factor in the Luxembourgish Parkinson’s study

Pachchek S. et al, (2023), npj Parkinson's Disease, 9

Normal and pathogenic variation of RFC1 repeat expansions: implications for clinical diagnosis

Dominik N. et al, (2023), Brain, 146, 5060 - 5069

Entorhinal cortex epigenome-wide association study highlights four novel loci showing differential methylation in Alzheimer’s disease

Sommerer Y. et al, (2023), Alzheimer's Research and Therapy, 15

Author Correction: Accurate long-read sequencing identified GBA1 as major risk factor in the Luxembourgish Parkinson’s study (npj Parkinson's Disease, (2023), 9, 1, (156), 10.1038/s41531-023-00595-w)

Pachchek S. et al, (2023), Npj Parkinson S Disease, 9

Investigating gait-responsive somatosensory cueing from a wearable device to improve walking in Parkinson’s disease

Li D. et al, (2023), BioMedical Engineering Online, 22

Genetic meta-analysis of levodopa induced dyskinesia in Parkinson’s disease

Martinez-Carrasco A. et al, (2023), npj Parkinson's Disease, 9

More publications

Theme 2: Cellular

Correction: Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons (Molecular Neurodegeneration, (2023), 18, 1, (87), 10.1186/s13024-023-00673-w)

Hasan S. et al, (2023), Molecular Neurodegeneration, 18

Integration of 3D-printed cerebral cortical tissue into an ex vivo lesioned brain slice

Jin Y. et al, (2023), Nature Communications, 14

C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9

Vahsen BF. et al, (2023), Nature Communications, 14

CRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neuronal cell death

Pavlou S. et al, (2023), Scientific Reports, 13

Patient-derived iPSC models of Friedreich ataxia: a new frontier for understanding disease mechanisms and therapeutic application

Maheshwari S. et al, (2023), Translational Neurodegeneration, 12

Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons

Hasan S. et al, (2023), Molecular Neurodegeneration, 18

Aquaporins in GtoPdb v.2023.3

Bill RM. et al, (2023), IUPHAR/BPS Guide to Pharmacology CITE, 2023

Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson's

Brimblecombe K. et al, (2023), European Journal of Neuroscience, 59, 1242 - 1259

The Concise Guide to PHARMACOLOGY 2023/24: Ion channels

Alexander SPH. et al, (2023), British Journal of Pharmacology, 180, S145 - S222

Mitochondrial dysfunction and mitophagy defects in LRRK2-R1441C Parkinson's disease models

Williamson MG. et al, (2023), Human Molecular Genetics, 32, 2808 - 2821

More publications

Theme 3: Models

Lights, fiber, action! A primer on in vivo fiber photometry

Simpson EH. et al, (2023), Neuron, 112, 718 - 739

Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson's

Brimblecombe K. et al, (2023), European Journal of Neuroscience, 59, 1242 - 1259

Axo-glial interactions between midbrain dopamine neurons and oligodendrocyte lineage cells in the anterior corpus callosum

Caldwell M. et al, (2023), Brain Structure and Function, 228, 1993 - 2006

MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress

Carvalho AL. et al, (2023)

Discovery of CVN417, a Novel Brain-Penetrant α6-Containing Nicotinic Receptor Antagonist for the Modulation of Motor Dysfunction

Christie LA. et al, (2023), Journal of Medicinal Chemistry, 66, 11718 - 11731

Intersectin and Endophilin condensates prime synaptic vesicles for release site replenishment.

Ogunmowo T. et al, (2023), bioRxiv

Impaired dopamine release in Parkinson's disease

Cramb KML. et al, (2023), Brain, 146, 3117 - 3132

A Selective Projection from the Subthalamic Nucleus to Parvalbumin-Expressing Interneurons of the Striatum

Kondabolu K. et al, (2023), Eneuro, 10

The aperiodic exponent of subthalamic field potentials reflects excitation/inhibition balance in Parkinsonism

Wiest C. et al, (2023), Elife, 12

Theme 1: Clinical

Theme 2: Cellular

Theme 3: Models

Cookies on this website

OPDC Publications

Mitochondrial Dysfunction and Mitophagy in Parkinson's Disease

Theme 1: Clinical

Theme 2: Cellular

Theme 3: Models

2025

Theme 1: Clinical

Theme 2: Cellular

Theme 3: Models

2024

Theme 1: Clinical

Theme 2: Cellular

Theme 3: Models

2023

Theme 1: Clinical

Theme 2: Cellular

Theme 3: Models

2022

2021

2020

2019

2018

2017

2016

2015

2014

2013

2012

2011