We investigate neuroimmune molecular mechanisms underlying obesity.
The Domingos laboratory researches neuroimmune mechanisms underlying obesity. They discovered the sympathetic neuro-adipose junction, a functional synapse-like connection between white adipocytes and the sympathetic nervous system (Cell 2015). They found that this neuro-adipose junction is necessary and sufficient for fat mass reduction via norepinephrine (NE) signaling (Cell 2015, Nature Comm 2017). They then discovered Sympathetic neuron-Associated Macrophages (SAMs) that directly import and metabolize NE. Abrogation of SAM function promotes long-term amelioration of obesity independently of food intake (Nature Medicine, 2017).
© Guttenplan, Kevin A. et al. (2018) Play It Again, SAM: Macrophages Control Peripheral Fat Metabolism, Trends in Immunology, and Conor A. Bradley (2017). Specialized macrophages contribute to obesity. Nature Reviews Endocrinology.
© Lady Margaret Hall / Dominik Osvald / www.dominikosvald.com
The Domingos Lab is proud to be sponsored by the following funding bodies:
The paper, 'Brain-Sparing Sympathofacilitators Mitigate Obesity without Adverse Cardiovascular Effects' has been featured in:
- Alan Morris (2020): Unravelling novel weight loss mechanisms. Nature Reviews Endocrinology.
- Jung Dae Kim and Sabrina Diano (2020): A Sympathetic Treatment for Obesity. Cell Metabolism.
The paper, 'Sympathetic neuron-associated macrophages contribute to obesity by importing and metabolizing norepinephrine' has been featured in:
- Stefan Jung: Year in Review — Macrophages and monocytes in 2017: Macrophages and monocytes: of tortoises and hares. Nature Reviews Immunology 2017
- Conor A. Bradley (2017). Specialized macrophages contribute to obesity. Nature Reviews Endocrinology.
- Making Fat Mice Lean: Novel Immune Cells Control Neurons Responsible For Fat Breakdown. ScienMag.
- Wei Wong (14 Nov 2017). Fat expansion through norepinephrine catabolism. Editor's Choice, Science Signalling.
- Seth Thomas Scanlon (17 Nov 2017), Unusual macrophages contribute to obesity. Editor's Choice, Science
- Guttenplan, Kevin A. et al. (2018) Play It Again, SAM: Macrophages Control Peripheral Fat Metabolism, Trends in Immunology
- Michael P Czech (7 Nov 2017), Macrophages dispose of catecholamines in adipose tissue. Nature Medicine
The paper, 'Sympathetic neuro-adipose connections mediate leptin-driven lipolysis' has been featured in:
- Johan Ruud & Jens Bruening (2015). Metabolism: Light on leptin link to lipolysis. Nature
- Natasha Bray (2015). Zapping fat in WAT, Nature Reviews Neuroscience
- News and Views (2015). A closer look at the nerves that slim down your fat cells, Science
- Luis Varela, Tamas L. Horvath (2015). A Sympathetic View on Fat by Leptin, Cell
- Qingchun Tong (2015) Exceptional F1000 Physiology, Technical Advance
- Mark Bothwell (2015) Very Good F1000 Neuroscience, New Finding
MRC London Institute of Medical Sciences, Inter-organ Communication in Health and Disease Virtual Symposium, November 24 2020, Session 1: ‘Signalling stress and disease’ 2:20 – 2:30 pm. Register here.
GRC, Neuroimmunology in Organismic Function: Shared Mechanisms and Reciprocal Interactions, California, USA, January 24 - 29 2021.
Keystone Symposia, Obesity: From Cell to Patient, Vancouver, Canada, January 29 - February 2 2021.
GRC, Gordon Research Conference: Immune System in Health, Disease and Therapy, Castelldefels, Spain, Postponed to 2022.
Check out some pictures from the event here.
Type 2 Immunity in Homeostasis and Disease - 21-22 February 2019
EMBO Workshop, Organ crosstalk in energy balance and metabolic disease, Sancti Petri, Chiclana, Cádiz, Spain, April 8-11 2019
Aegean Conferences, 4th International Conference on ImmunoMetabolism: Molecular and Cellular Immunology of Metabolism, Rhodes, Greece May 28 - June 2 2019
ICMS, 14th World Congress on Inflammation, Sydney, September 15-19 2019
Cell Symposia, Neuro-Immune Axis: Reciprocal Regulation in Development, Health and Disease, Long Beach, California, September 22-24 2019
Nature Conferences, Advances in Metabolic Communication, Rio de Janeiro, Brazil, October 15 - 18 2019
Gastronauts Zoom-side Chat: Why we self medicate, Virtual Meeting, Tuesday 7 April 2020
Neuroscience School of Advanced Studies (NSAS), Neuroscience of Obesity, Venice, Italy, June 6 - 13 2020
Cell Symposia, Metabolites in Signalling and Disease, Lisbon, Portugal, October 25 - 27 2020
Naomi Berrie Diabetes Center Seminars at Columbia University, “Sympathetic Neuroimmunity in Obesity”, November 12 2020