Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we will assume that you are happy to receive all cookies and you will not see this message again. Click 'Find out more' for information on how to change your cookie settings.

We dissect the molecular and cellular mechanisms underlying a range of developmental and reproductive processes.

© Intracellular compartments in Drosophila secondary cells (Benjamin Kroeger)

Understanding growth, evolution and the onset of disease

Our development and cell biology theme is home to the largest assembly of developmental biologists in the University, and tackles research questions fundamental to understanding evolution, growth, organ formation, the onset of disease and tissue regeneration.

While our research interests are diverse and necessarily cut across other themes with the department, all of our work is guided by a fundamental desire to dissect the molecular and cellular mechanisms which underlie developmental and reproductive processes. The majority of our work is conducted in vivo, embracing the inherent complexity of using model organisms in order to acquire the most clinically relevant findings possible.

Our research is, through necessity, multidisciplinary, bringing together techniques such as state-of-the-art live cell imaging and genetic analysis to understand the developmental, evolutionary, and reproductive aspects of life. Our researchers currently study some of the most fundamental questions facing biology today: how cells are regulated to move and correctly develop embryos, for instance, or the basic science which dictates healthy development of cerebral and cardiovascular systems.

Unsurprisingly, our research is having a significant impact on clinical thinking. While some aspects of our work focus  specifically on disease-related problems - such as the regulation of growth and its relevance to cancer and diabetes - others tackle issues that look set to become increasingly important in the near future, such as how to restore embryonic potential to adult stem cells for tissue repair.

All told, we believe that by understanding development, it is possible to shed light on some of the current and future challenges in translating basic biological understanding into clinical medicine.



Groups within this theme

Understanding Cerebellar Development and Disease
Becker Group

Understanding Cerebellar Development and Disease

Optical probing of neural networks in the developing neocortex
Butt Group

Optical probing of neural networks in the ...

Regulation of blood and lymphatic vessel development
De Val Group

Regulation of blood and lymphatic vessel ...

Proton dependence of intracellular calcium signalling in the cerebellum in health and disease - role of extracellular pH sensing receptors and ion channels.
Glitsch Group

Proton dependence of intracellular calcium ...

Growth Regulation and Cancer: mTORC1, Exosomes and Cellular Amino Acid Sensing
Goberdhan Group

Growth Regulation and Cancer: mTORC1, Exosomes ...

Genetic Dissection of Sexual Behaviour
Goodwin Group

Genetic Dissection of Sexual Behaviour

Cerebral Cortical Development and Evolution
Molnar Group

Cerebral Cortical Development and Evolution

Heart regeneration & development
Mommersteeg Group

Heart regeneration & development

Development, homeostasis and regeneration of the cardiovascular system
Smart Group

Development, homeostasis and regeneration of the ...

Investigating the Genetic and Environmental Causes of Congenital Heart Disease
Sparrow Group

Investigating the Genetic and Environmental ...

Patterning and morphogenesis of the early mammalian embryo
Srinivas Group

Patterning and morphogenesis of the early ...

Spatiotemporal dissection of vascular heterogeneity
Stone Group

Spatiotemporal dissection of vascular ...

We study postnatal and adult mammalian brain stem cells to uncover fundamental developmental mechanisms and disease pathogenesis.
Szele Group

We study postnatal and adult mammalian brain stem ...

Cell Biology of Exosome Signalling, Secretion and Growth in Normal and Cancer Cells at Super-Resolution
Wilson Group

Cell Biology of Exosome Signalling, Secretion and ...

Latest news

Dr Oliver Stone starts research group as Sir Henry Dale Fellow

Dr Stone has been awarded a Wellcome Trust Henry Dale Fellowship to lead research investigating how lineage history can impact vascular cell fate and function.

COVID-19 drug trial could lead to enhanced respiratory care for patients

Researchers at the University of Oxford led by DPAG's Professor Peter Robbins are working with clinical collaborators from NHS hospitals to carry out a new clinical drug trial aimed at treating COVID-19, funded by LifeArc. It will test a drug that could raise oxygen levels in the blood in COVID-19 patients in order to improve their chances of recovery. Raising oxygen levels is important in COVID-19, because many patients with the disease die when oxygen levels in their arterial blood fall to levels that are too low to support life.

HCQ with antibiotics to treat COVID-19 could be dangerous for the heart

DPAG researchers have collaborated on an international study that demonstrates a detailed mechanistic understanding of how the anti-malaria drug, Hydroxychloroquine, combined with antibiotics, can cause adverse cardiac side-effects in COVID-19 patients. This gives weight to US Federal advice against using this combined treatment.