Memory, motivation and neural transposition
Directed behaviour emerges from neural integration of sensory stimuli, memory of prior experience and internal states. The Waddell group seeks an understanding of these conserved neural mechanisms using genetically-encoded tools and the relatively small brain of Drosophila. By temporally controlling neural function memories can be implanted and internal states altered so that most flies behave according to our direction. Such recent studies have revealed a role for distinct subsets of dopaminergic neurons that innervate the mushroom bodies in reward learning and the control of motivated fly behaviour. Therefore, the positive reinforcement system of flies is more similar to that of mammals than previously envisaged.
One might interpret the relative ease of altering behaviour to indicate that everything is simple in the fly brain. However, complexity may arise in unexpected ways. Cell-type specific gene expression profiling revealed transposable element expression in long-term memory relevant neurons of the mushroom body. Importantly, neural transposon mobilization is prevalent and likely to be heterogeneous within and between fly brains. Since neural expression and retrotransposition of LINE-1 transposable elements has been observed in mammals, it appears that genomic heterogeneity is a conserved feature of the brain. We are particularly interested in the implied cell-type biased nature of neural transposition and whether the stochasticity of transposition could contribute to cellular and organismal individuality.
We are part of the Centre for Neural Circuits and Behaviour along with the groups of Gero Miesenböck, Martin Booth, Stephen Goodwin, Korneel Hens and Tim Vogels.
5th December 2016
Many congratulations to my first Oxford Ph.D. student, the very talented Christoph [Charlie] Treiber who defended his thesis today.
1st July 2016
On a roll, latest from Emmanuel, David, Oliver and co-authors, now published in Neuron.
Multi-tasking inhibition in the fly brain
7th March 2016
Congratulations to Oliver, David, Johannes and co-authors on their paper, now online in Neuron.
At last we know the identity of a fast-acting neurotransmitter released from the Drosophila mushroom bodies.
Interesting Press Attention
The lab was featured in an article by Philip Ball in The Guardian /Observer.
Suewei Lin's work on water reward and thirst was featured in an article in The New Yorker from Jonathan Weiner, author of Time, Love and Memory.