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We play a leading role in the development of more efficient and cost-effective sequencing technologies.

Male Drosophila accessory gland

Understanding genetics through computation and experimentation

Our functional genomics program combines theory and practice to capitalize on the wealth of information available from genomic sequencing. We’re driven by a desire to understand human disease through analysing patients and relevant animal models – which means our work can often be translated into clinical practice.

Much of our work is based on the core principle of using model organisms to better understand human disease. A major driving force behind our research, for instance, is the MRC Functional Genomics Unit (FGU). Using genomic information from patients, it combines rigorous computational analysis and interpretation to identify the genetic origins of common neurological diseases such as Parkinson’s and multiple sclerosis.

Elsewhere, our researchers work across a wide range of diseases, but are always led by clinical relevance. Studying the single gene defects responsible for Duchenne muscular dystrophy has led to effective treatments for the disease in mice which are now being translated for use in human, for instance, while computational analysis of enormous genomic data sets is shedding light on the origins of neurodevelopmental disorders like autism and ADHD. Even some of our most basic work, such as fruit fly genetics, is resulting in the discovery of new cellular organelles and uncovering the basis of sexual development.

In the future, the availability of genomic data looks set to increase exponentially, and our Computational Genomics Analysis and Training Programme (www.cgat.org) is equipping researchers from a diverse range of backgrounds to process and interpret their results more efficiently. While there’s no denying that genomic information has begun to transform the treatment of patients, we hope to ensure it will increasingly make good on its early promise and continues to flourish.



Groups within this theme

Understanding Cerebellar Development and Disease
Becker Group

Understanding Cerebellar Development and Disease

Molecular Analysis of Neuromuscular Diseases
Davies Group

Molecular Analysis of Neuromuscular Diseases

We investigate neuroimmune molecular mechanisms underlying obesity.
Domingos Group

We investigate neuroimmune molecular mechanisms ...

Genetic Dissection of Sexual Behaviour
Goodwin Group

Genetic Dissection of Sexual Behaviour

Sleep, brain and behaviour laboratory
Vyazovskiy Group

Sleep, brain and behaviour laboratory

Understanding molecular mechanisms of age-related neurodegenerative diseases to generate novel molecular therapies
Wade-Martins Group

Understanding molecular mechanisms of age-related ...

Cell Biology of Exosome Signalling, Secretion and Growth in Normal and Cancer Cells at Super-Resolution
Wilson Group

Cell Biology of Exosome Signalling, Secretion and ...

Latest news

New human heart model set to boost future cardiac research and therapies

DPAG's Dr Jakub Tomek and Professor Blanca Rodriguez's Computational Cardiovascular Science Team have developed a new computer model that recreates the electrical activity of the ventricles in a human heart. In doing so, they have uncovered and resolved theoretical inconsistencies that have been present in almost all models of the heart from the last 25 years and created a new human heart model that could enable more basic, translational and clinical research into a range of heart diseases and potentially accelerate the development of new therapies.

New target identified for repairing the heart after heart attack

An immune cell is shown for the first time to be involved in creating the scar that repairs the heart after damage. The Riley Group study was funded by the British Heart Foundation and led by BHF CRE Intermediate Transition Research Fellow Dr Filipa Simões.

New insights into how the brain makes sense of our constantly changing soundscape

We experience a wide range of sounds at varying levels. The brain's auditory neurons constantly adapt their responses to changes in sound level to help us perceive and understand what we hear. King Group researchers have previously demonstrated how these neurons do this and have now produced new evidence for exactly where this happens in the brain and the perceptual consequences of these adaptations.