About Us
The Oxford Parkinson's Disease Centre (OPDC) is a unique multidisciplinary research program at the University of Oxford. The OPDC was established in February 2010 and brings together internationally-renowned scientists who work on the genetics of Parkinson’s, the generation of cell and animal models, and the wiring of brain circuits which control movement, with clinical experts in the diagnosis and treatment of Parkinson’s.
Our world-class research centre works to understand the earliest events in the development of Parkinson’s with an ultimate view to target the molecular mechanisms of disease with neuroprotective therapies to prevent disease onset or delay progression.
Our program is focused on the molecular pathways to Parkinson’s in order to:
- Predict the onset of Parkinson’s
- Understand the progression of Parkinson’s
- Identify potential drug targets for Parkinson's
- Develop new treatments that will prevent the development of Parkinson’s in at-risk individuals.
Watch the video below to learn more about OPDC's research:
Latest News
World Parkinson’s Day: AD/PD 2026 Highlights
10 April 2026
OPDC researchers support World Parkinson’s Day 2025
22 April 2025
Latest publications
Human induced pluripotent stem cell-derived microglia with 1q21.1 deletion and duplication exhibit aberrant inflammatory response
Journal article
Singh T. et al, (2026), Genes and Diseases, 13
Injected extracellular vesicles and other nanoparticles hitchhike on erythrocytes and platelets from circulation towards organ clearance
Journal article
Pavlova S. et al, (2026), Extracellular Vesicle, 7
Channelrhodopsin Ion Selectivity Determines Mechanisms and Efficacy of Optogenetic Defibrillation in Human Atria and Ventricles
Preprint
Ohnemus S. et al, (2026)
Rethinking hierarchy: the auditory system as an integrated cortical-subcortical network.
Journal article
Lohse M. et al, (2026), Nat Rev Neurosci
Defective regulated secretion: A trigger for Alzheimer's pathology?
Journal article
Verma B. et al, (2026), Prog Neurobiol, 262
Synthesis of aryl-fused bicyclo[3.1.1]heptanes and validation as naphthyl bioisosteres.
Journal article
Kerckhoffs A. et al, (2026), Nat Chem

