About Us
The Oxford Parkinson's Disease Centre (OPDC) is a unique multidisciplinary research program at the University of Oxford. The OPDC was established in February 2010 and brings together internationally-renowned scientists who work on the genetics of Parkinson’s, the generation of cell and animal models, and the wiring of brain circuits which control movement, with clinical experts in the diagnosis and treatment of Parkinson’s.
Our world-class research centre works to understand the earliest events in the development of Parkinson’s with an ultimate view to target the molecular mechanisms of disease with neuroprotective therapies to prevent disease onset or delay progression.
Our program is focused on the molecular pathways to Parkinson’s in order to:
- Predict the onset of Parkinson’s
- Understand the progression of Parkinson’s
- Identify potential drug targets for Parkinson's
- Develop new treatments that will prevent the development of Parkinson’s in at-risk individuals.
Watch the video below to learn more about OPDC's research:
Latest News
Upcoming Seminars
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Tuesday, 28 October 2025, 12pm to 1pm
Speakers: Professor Peter Vangheluwe
Latest publications
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New insights into axonal regulators of dopamine transmission in health and disease.
Journal article
Todd KL. et al, (2025), Curr Opin Neurobiol, 94
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Altered network efficiency in isolated REM sleep behavior disorder: A multicentric study.
Journal article
Tremblay C. et al, (2025), Alzheimers Dement, 21
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Diagnostic and prognostic value of α-synuclein seed amplification assay kinetic measures in Parkinson's disease: a longitudinal cohort study
Journal article
Orrú CD. et al, (2025), Lancet Neurology, 24, 580 - 590
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Formation of seeding-competent α-synuclein aggregates in parkin-deficient iPSC-derived human neurons.
Journal article
Schmidt SI. et al, (2025), NPJ Parkinsons Dis, 11
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SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides.
Journal article
Loreto A. et al, (2025), Neurobiol Dis
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Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorder.
Journal article
Joza S. et al, (2025), EBioMedicine