About Us
The Oxford Parkinson's Disease Centre (OPDC) is a unique multidisciplinary research program at the University of Oxford. The OPDC was established in February 2010 and brings together internationally-renowned scientists who work on the genetics of Parkinson’s, the generation of cell and animal models, and the wiring of brain circuits which control movement, with clinical experts in the diagnosis and treatment of Parkinson’s.
Our world-class research centre works to understand the earliest events in the development of Parkinson’s with an ultimate view to target the molecular mechanisms of disease with neuroprotective therapies to prevent disease onset or delay progression.
Our program is focused on the molecular pathways to Parkinson’s in order to:
- Predict the onset of Parkinson’s
- Understand the progression of Parkinson’s
- Identify potential drug targets for Parkinson's
- Develop new treatments that will prevent the development of Parkinson’s in at-risk individuals.
Watch the video below to learn more about OPDC's research:
Latest News
Upcoming Seminars
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Thursday, 10 July 2025, 4pm to 5pm
Speakers: Assistant Prof. Briana R. De Miranda
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Thursday, 10 July 2025, 4pm to 5pm
Speakers: Assistant Professor Briana R. De Miranda
Latest publications
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SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides.
Journal article
Loreto A. et al, (2025), Neurobiol Dis
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Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorder.
Journal article
Joza S. et al, (2025), EBioMedicine
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The profile of gastrointestinal dysfunction in prodromal to late-stage Parkinson's disease.
Journal article
Camacho M. et al, (2025), NPJ Parkinsons Dis, 11
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Dopamine D2 receptor upregulation in dorsal striatum in the LRRK2-R1441C rat model of early Parkinson's disease revealed by in vivo PET imaging.
Journal article
Delgado-Goñi T. et al, (2025), Sci Rep, 15
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Working memory filtering at encoding and maintenance in healthy ageing, Alzheimer's and Parkinson's disease.
Journal article
Toniolo S. et al, (2025), Sci Rep, 15
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Cholinergic degeneration in prodromal and early Parkinson's: a link to present and future disease states.
Journal article
Eisenstein T. et al, (2025), Brain