The Oxford Parkinson's Disease Centre (OPDC) is a unique multidisciplinary research program at the University of Oxford. The OPDC was established in February 2010 and brings together internationally-renowned scientists who work on the genetics of Parkinson’s, the generation of cell and animal models, and the wiring of brain circuits which control movement, with clinical experts in the diagnosis and treatment of Parkinson’s.
Our world-class research centre works to understand the earliest events in the development of Parkinson’s with an ultimate view to target the molecular mechanisms of disease with neuroprotective therapies to prevent disease onset or delay progression.
Our program is focused on the molecular pathways to Parkinson’s in order to:
- Understand the progression of Parkinson’s
- Predict the onset of Parkinson’s
- Identify potential drug targets for Parkinson’s
- Develop new treatments that will prevent the development of Parkinson’s in at-risk individuals.
Watch the video below to learn more about OPDC's research:
Wednesday, 06 December 2023, 4pm to 5pm
Tuesday, 09 January 2024, 2pm to 3pm
Accurate long-read sequencing identified GBA1 as major risk factor in the Luxembourgish Parkinson’s study
Pachchek S. et al, (2023), npj Parkinson's Disease, 9
Investigating gait-responsive somatosensory cueing from a wearable device to improve walking in Parkinson's disease.
Li D. et al, (2023), Biomed Eng Online, 22
Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons.
Hasan S. et al, (2023), Mol Neurodegener, 18
A programme evaluation of 'First Steps': A peer-conceived, developed and led self-management intervention for people after a Parkinson's diagnosis.
Collett J. et al, (2023), Clin Rehabil
Axo-glial interactions between midbrain dopamine neurons and oligodendrocyte lineage cells in the anterior corpus callosum.
Caldwell M. et al, (2023), Brain Struct Funct, 228, 1993 - 2006
Investigation of the genetic aetiology of Lewy body diseases with and without dementia.
Wu L. et al, (2023), medRxiv