About Us
The Oxford Parkinson's Disease Centre (OPDC) is a unique multidisciplinary research program at the University of Oxford. The OPDC was established in February 2010 and brings together internationally-renowned scientists who work on the genetics of Parkinson’s, the generation of cell and animal models, and the wiring of brain circuits which control movement, with clinical experts in the diagnosis and treatment of Parkinson’s.
Our world-class research centre works to understand the earliest events in the development of Parkinson’s with an ultimate view to target the molecular mechanisms of disease with neuroprotective therapies to prevent disease onset or delay progression.
Our program is focused on the molecular pathways to Parkinson’s in order to:
- Predict the onset of Parkinson’s
- Understand the progression of Parkinson’s
- Identify potential drug targets for Parkinson's
- Develop new treatments that will prevent the development of Parkinson’s in at-risk individuals.
Watch the video below to learn more about OPDC's research:
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Latest publications
Mutant TDP-43 drives impairments in axonal transport and glycolysis in a mouse stem-cell-derived motor neuron model of amyotrophic lateral sclerosis (ALS)
Journal article
Carroll E. et al, (2026), Cell Death and Disease, 17
Distinct roles of cortical layer 5 subtypes in associative learning
Journal article
Moberg S. et al, (2026), Nature Communications, 17
Dynamins maintain nuclear envelope homeostasis and genome stability
Journal article
Aveleira C. et al, (2026), Nature Communications, 17
Whole-exome sequencing in children with dyslexia implicates rare variants in CLDN3 and ion channel genes
Journal article
Marianski K. et al, (2026), Human Genetics, 145
Vigilance state dissociation induced by 5-MeO-DMT in mice
Journal article
Bréant BJB. et al, (2026), Communications Biology, 9
Suppression of pathological oscillations with transcranial focused ultrasound in Parkinson’s disease
Journal article
Eraifej J. et al, (2026), Nature Communications, 17