About Us
The Oxford Parkinson's Disease Centre (OPDC) is a unique multidisciplinary research program at the University of Oxford. The OPDC was established in February 2010 and brings together internationally-renowned scientists who work on the genetics of Parkinson’s, the generation of cell and animal models, and the wiring of brain circuits which control movement, with clinical experts in the diagnosis and treatment of Parkinson’s.
Our world-class research centre works to understand the earliest events in the development of Parkinson’s with an ultimate view to target the molecular mechanisms of disease with neuroprotective therapies to prevent disease onset or delay progression.
Our program is focused on the molecular pathways to Parkinson’s in order to:
- Understand the progression of Parkinson’s
- Predict the onset of Parkinson’s
- Identify potential drug targets for Parkinson’s
- Develop new treatments that will prevent the development of Parkinson’s in at-risk individuals.
Watch the video below to learn more about OPDC's research:
Latest News
How can sleep improve Parkinson's care?
6 February 2024
Upcoming Seminars
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Monday, 25 March 2024, 12pm to 1pm
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Tuesday, 16 April 2024, 12pm to 1pm
Latest publications
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Single-cell spatial transcriptomic and translatomic profiling of dopaminergic neurons in health, aging, and disease.
Journal article
Kilfeather P. et al, (2024), Cell Rep, 43
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Tau depletion in human neurons mitigates Aβ-driven toxicity.
Journal article
Ng B. et al, (2024), Mol Psychiatry
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Two sample Mendelian Randomisation using an outcome from a multilevel model of disease progression.
Journal article
Lawton M. et al, (2024), Eur J Epidemiol
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Transitioning from Subtyping to Precision Medicine in Parkinson's Disease: A Purpose-Driven Approach.
Journal article
Marras C. et al, (2024), Mov Disord
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A pathogenic variant in RAB32 causes autosomal dominant Parkinson's disease and activates LRRK2 kinase.
Journal article
Gustavsson EK. et al, (2024), medRxiv
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Correction: Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons.
Journal article
Hasan S. et al, (2023), Mol Neurodegener, 18