Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we will assume that you are happy to receive all cookies and you will not see this message again. Click 'Find out more' for information on how to change your cookie settings.
We are recognised internationally for our pioneering approaches to systems biology and to computational modelling of the heart.
Cardiac Sciences

We are recognised internationally for our ...

We study everything from the structure of ion channels and transporters right up to their role in behaviour and human disease.
Cell Physiology

We study everything from the structure of ion ...

We dissect the molecular and cellular mechanisms underlying a range of developmental and reproductive processes.
Development & Cell Biology

We dissect the molecular and cellular mechanisms ...

We play a leading role in the development of more efficient and cost-effective sequencing technologies.
Functional Genomics

We play a leading role in the development of more ...

We use the full range of modern molecular genetic and imaging techniques to study a range of metabolic areas.
Metabolism & Endocrinology

We use the full range of modern molecular genetic ...

We host a number of internationally recognised neuroscience groups, with expertise in a wide range of experimental and computational methods.
Neuroscience

We host a number of internationally recognised ...

ATP-sensitive potassium (K-ATP) channels, insulin secretion and diabetes
Ashcroft Group

ATP-sensitive potassium (K-ATP) channels, insulin ...

Hearing Loss and Tinnitus
Bajo Lorenzana Group

Hearing Loss and Tinnitus

Cellular mechanisms of oxygen and acid sensing in arterial chemoreceptors
Buckler Group

Cellular mechanisms of oxygen and acid sensing in ...

Optical probing of neural networks in the developing neocortex
Butt Group

Optical probing of neural networks in the ...

Optimising cardiac stem cell therapy by finding the best conditions for the cells in the lab and in the heart
Carr Group

Optimising cardiac stem cell therapy by finding ...

Glucocorticoids, Annexin 1 and the Neuroendocrine–Immune Interface
Christian Group

Glucocorticoids, Annexin 1 and the ...

Ketone metabolism in exercise and disease
Clarke Group

Ketone metabolism in exercise and disease

Monoamine transmission: from mechanisms to movement
Cragg Group

Monoamine transmission: from mechanisms to ...

Molecular Analysis of Neuromuscular Diseases
Davies Group

Molecular Analysis of Neuromuscular Diseases

Regulation of blood and lymphatic vessel development
De Val Group

Regulation of blood and lymphatic vessel ...

Role of ABC transporters in gut endocrine K-and L-cells
de Wet Group

Role of ABC transporters in gut endocrine K-and ...

We investigate neuroimmune molecular mechanisms underlying obesity.
Domingos Group

We investigate neuroimmune molecular mechanisms ...

Proton dependence of intracellular calcium signalling in the cerebellum in health and disease - role of extracellular pH sensing receptors and ion channels.
Glitsch Group

Proton dependence of intracellular calcium ...

Growth Regulation and Cancer: mTORC1, Exosomes and Cellular Amino Acid Sensing
Goberdhan Group

Growth Regulation and Cancer: mTORC1, Exosomes ...

Genetic Dissection of Sexual Behaviour
Goodwin Group

Genetic Dissection of Sexual Behaviour

Abnormal metabolism in type 2 diabetes, and how this affects the heart
Heather Group

Abnormal metabolism in type 2 diabetes, and how ...

Local neuromodulators of cardiac autonomic control
Herring Group

Local neuromodulators of cardiac autonomic control

Neural coding and plasticity in the auditory system
King Group

Neural coding and plasticity in the auditory ...

Spatial organization of fat metabolism.
Klemm Group

Spatial organization of fat metabolism.

Circuit Mechanisms of Learning and Decision Making
Lak Group

Circuit Mechanisms of Learning and Decision Making

Iron Homeostasis- Mechanisms and importance in systems (patho)physiology
Lakhal-Littleton Group

Iron Homeostasis- Mechanisms and importance in ...

Laboratory of Oscillations & Plasticity
Mann Group

Laboratory of Oscillations & Plasticity

Optical Control of Neurons;
Neuronal Control of Behaviour
Miesenboeck Group

Optical Control of Neurons; Neuronal Control of ...

Cerebral Cortical Development and Evolution
Molnar Group

Cerebral Cortical Development and Evolution

Heart regeneration & development
Mommersteeg Group

Heart regeneration & development

Intracellular calcium signalling in health and disease
Parekh Group

Intracellular calcium signalling in health and ...

Neural systems and circuits for visual perception
Parker Group

Neural systems and circuits for visual perception

Gene Transfer of Nitric Oxide Synthase into Cardiac Nerves Modulates Neurotransmission
Paterson Group

Gene Transfer of Nitric Oxide Synthase into ...

Human systems physiology: Respiratory, cardiovascular and metabolic function in response to stresses such as exercise and hypoxia
Robbins Group

Human systems physiology: Respiratory, ...

Development, homeostasis and regeneration of the cardiovascular system
Smart Group

Development, homeostasis and regeneration of the ...

Investigating the Genetic and Environmental Causes of Congenital Heart Disease
Sparrow Group

Investigating the Genetic and Environmental ...

Patterning and morphogenesis of the early mammalian embryo
Srinivas Group

Patterning and morphogenesis of the early ...

Spatiotemporal dissection of vascular heterogeneity
Stone Group

Spatiotemporal dissection of vascular ...

Acid handling and signalling in the heart and in cancer
Swietach Group

Acid handling and signalling in the heart and in ...

We study postnatal and adult mammalian brain stem cells to uncover fundamental developmental mechanisms and disease pathogenesis.
Szele Group

We study postnatal and adult mammalian brain stem ...

Translational cardiorespiratory physiology, with a focus on hypoxia and iron.
Talbot Group

Translational cardiorespiratory physiology, with ...

Development and Application of Cardiac Magnetic Resonance Imaging and Spectroscopy
Tyler Group

Development and Application of Cardiac Magnetic ...

Investigating regulatory mechanisms of cardiac development, repair and regeneration.
Vieira Group

Investigating regulatory mechanisms of cardiac ...

Sleep, brain and behaviour laboratory
Vyazovskiy Group

Sleep, brain and behaviour laboratory

Memory, motivation and individuality
Waddell Group

Memory, motivation and individuality

Understanding molecular mechanisms of age-related neurodegenerative diseases to generate novel molecular therapies
Wade-Martins Group

Understanding molecular mechanisms of age-related ...

We investigate how the activity of neurons in the brain give rise to our perception of sound.
Walker Group

We investigate how the activity of neurons in the ...

Membrane transport in cartilage and cancer cells
Wilkins Group

Membrane transport in cartilage and cancer cells

Exosomes, Microcarriers and Regulated Secretion: Complex Forms of Inter-Cellular and Inter-Organism Communication
Wilson Group

Exosomes, Microcarriers and Regulated Secretion: ...

Cyclic Nucleotides signalling
Zaccolo Group

Cyclic Nucleotides signalling

Jeol 1010 Transmission Electron Microscope (TEM) allowing 2D imaging of specimen ultrastructure at up to 100,000x magnification.
Electron Microscopy

Jeol 1010 Transmission Electron Microscope (TEM) ...

Specialising in Cryosectioning, Immunohistochemistry and Light microscopy histological techniques.
Histology

Specialising in Cryosectioning, ...

Well equipped and versatile Media Services Unit in the Le Gros Clark Building. Services available to the wider University and external organisations.​
Media Services

Well equipped and versatile Media Services Unit ...

Two high resolution Magnetic resonance imaging systems, specialising in in vivo cine and cardiac MRI. We also have access to Hyperpolarized magnetic resonance imaging capabilities.
Preclinical Imaging Facilities

Two high resolution Magnetic resonance imaging ...

Latest news

Iron deficiency anaemia in early pregnancy increases risk of heart defects, suggests new research

In animal models, iron deficient mothers have a greatly increased risk of having offspring with congenital heart disease (CHD). The risk of CHD can be greatly reduced if the mother is given iron supplements very early in pregnancy. Additionally, embryos from a mouse model of Down Syndrome were particularly vulnerable to the effects of maternal iron deficiency, leading to a higher risk of developing severe heart defects.

New target to develop immunosuppressants

A new study from the Parekh Group has resolved a long-standing question in our understanding of intracellular Ca2+ signalling, namely how a specific type of Ca2+ channel is uniquely able to signal to the nucleus to regulate gene expression. By unravelling this mechanism, researchers have identified a new approach for developing immunosuppressant drugs.

How the kidney contributes to healthy iron levels and disease

A new study from the Lakhal-Littleton Group has addressed a long-standing gap in our understanding of systemic iron homeostasis. It provides the first formal demonstration that the hormone hepcidin controls iron reabsorption in the kidney, in a manner that impacts the body’s iron levels, under normal physiological conditions. It also demonstrates for the first time how this mechanism becomes critically important in the development of iron disorders.