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Burdon Sanderson Cardiac Science and Integrative Physiology Centre

Directors

The Burdon Sanderson Cardiac Science Centre was established in 2005 as a multidisciplinary centre directed by Professor Manuela Zaccolo. It is dedicated to the science of normal and abnormal cardiac function. The overarching aims are to understand the physiology of the heart at the molecular, cellular and tissue levels. Researchers focus on key areas such as signal transduction, regulation of intracellular ionic concentration and metabolism, the neural control of cardiac activity as well as cardiac development. The Centre is uniquely placed in Oxford to achieve successfully these combined goals, because of its onsite linking of experimentation with integrative modelling. It forms part of the Oxford Cardiovascular Science strategic research network and is a core component of the BHF Centre of Research Excellence.

The Centre recently incorporated the Centre for Integrative Physiology, which aims to study organisms as functioning systems of molecules, cells, tissues, and organs, by researching fundamental physiological mechanisms and pathways. These span the whole breadth, from single genes to complex behaviour, in order to understand better normal human function and how disruption of these mechanisms leads to disease. There are overlaps and strong bonds with related areas, such as Neuroscience and Cardiac Science.

Learn more about The Burdon Sanderson Cardiac Science and Integrative Physiology Centre

Research Themes

A translucent scan of a surface fish in which the heart is shown in three distinct sections (red, yellow and green)

Cardiac Sciences

We are recognised internationally for our pioneering approaches to systems biology and to computational modelling of the heart.

Cell signalling captured in a group of converging activity

Cell Physiology

We study everything from the structure of ion channels and transporters right up to their role in behaviour and human disease.

Secondary cells shown as a cluster of 16 cells (green) next to a larger cell (red)

Development & Cell Biology

We dissect the molecular and cellular mechanisms underlying a range of developmental and reproductive processes.

Cells within the skin are represented as an oblong-shaped solid mass of multi coloured, almost mosaic-like structure

Metabolism & Endocrinology

We use the full range of modern molecular genetic and imaging techniques to study a range of metabolic areas.