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News

Expression of the Alzheimer’s-associated Aβ-peptide disrupts the normal aggregation of proteins inside secretory compartments. Two fly cells (each outlined by a white-dashed line) with about 10 secretory compartments, normally characterised by a central dense-core granule containing aggregated proteins (green; left-hand cell). Aβ-peptide expression disrupts this process (right-hand cell). Magenta staining indicates acidic compartments and ‘n’ the nuclei of these binucleate cells.

Researchers Identify New Mechanism Linked to Early Cellular Defects in Alzheimer’s Disease

a collage of photos showing teachers and scientists working together in labs and other University settings

Teacher’s residential 2025

Picasso’s sleeping ‘Woman with Yellow Hair’ (1931) becomes an arrangement of mitochondrial shapes. In a new study in Nature, Raffaele Sarnataro, Gero Miesenböck and colleagues identify mitochondrial electron flux as the root cause of sleep.

Why do we need sleep? Oxford researchers find the answer may lie in mitochondria

A New study uncovers how a metabolic “overload” in specialised brain cells triggers the need to sleep. Sleep may not just be rest for the mind - it may be essential maintenance for the body’s power supply.

Given sensory input delivered via layer 4, the “students” in layer 2/3 generate predictions (“Will the apple fall?”), which are then evaluated by comparing them to the actual sensory outcome provided by the “teacher” in layer 5. In this way, the sensory input itself supervises learning (self-supervision). Image shows illustration of man in profile with activities in brain

New research shows cortical layers implement AI-like predictive learning

Stevens Group logo

Soft microrobots bring precision drug delivery closer to clinical reality

Peter Beaconsfield Essay Prize - triple success

Professor Ana Domingos elected to EMBO membership

Molly Stevens pictured next to the Chapman medal

Professor Dame Molly Stevens awarded the IOM3 Chapman Medal

Illustration showing Baseline serum ferritin predicts myocardial iron uptake following intravenous iron therapy – a hypothesis‐generating study

Lakhal-Littleton Group's latest research on intravenous iron therapy is published in the European Journal of Heart Failure

Professor Ana Domingos one of seven Oxford academics awarded European Research Council Advanced Grants

BHF Fellowship Awarded to Explore the Hidden Role of Placental Blood Vessels in Pregnancy and Fetal Heart Health

photo of Mootaz Salman smiling

Dr Mootaz Salman awarded £1.5M BHF/ UK DRI Group Leader position to advance research on the blood-brain barrier in dementia and neurodegeneration

(left panel) transient expression of the serotonin transporter alongside increased REM sleep buffers cortical serotonin levels in the developing brain with (central panel) serotonin signalling only observed in response to aversive stimuli such as an air puff. (Right panel) dosing with SSRIs in early life can have long-term detrimental consequences for sensory-evoked neural activity with hyperactivity observed in animal exposed to the anti-depressant.

Butt Lab publish a study in Nature Communications on how changes in serotonin signalling affect perinatal brain development

photo taken from balcony showing busy event in the Kavli, Oxford

Oxford Parkinson’s Disease Centre hosts the 2025 Oxford Parkinson’s Research Day

Longitudinal tracking of long-term learning behaviour and striatal dopamine revealed that dopamine teaching signals shape individuals’ diverse yet systematic learning trajectories, captured mathematically by a deep neural network.

New Lak Lab paper published in Cell: dopamine signals for long-term learning

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A conversation with Professor Robert Langer ahead of his DPAG Kavli Sir Hans Krebs Lecture

an illustration showing Mechanism that drives excess fatty acid metabolism in diabetes involves a FoxO1-zDHHC4-CD36 S-acylation axis.

Paper published by Heather Group in Circulation Research identifies a new metabolic axis which explains why the diabetic heart becomes fatty

Professor Dame Molly Stevens among new Fellows announced by Academy of Medical Sciences

Rui Ponte Costa awarded title of Associate Professor

Photo of Professor Iyengar against a blue banner background

An interview with Professor Sheena S. Iyengar ahead of her Sherrington Public Understanding of Science lecture

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