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Proteome complexity in neurodegenerative and neuropsychiatric disease

© Credit: Laura Pearson
Cortical neurons growing in the Carlyle lab, coloured green to allow for tracing of processes

During our lifetimes, most of us will be personally affected by, or be close to someone with, mental health problems, or to someone who experiences memory problems as they get older.  These complicated brain diseases are still poorly understood, probably because their origins lie within a combination of genetic risk, exposure to environmental stressors, and differences in our behaviour, that cause subtle changes to the way our brain cells communicate with each other. These subtle changes, accumulated across a lifespan, lead to the development of the symptoms we experience. 

Our research uses a combination of proteomic techniques in post-mortem human brain tissue and experiments in cellular brain cell-models, to understand how protein-level changes in the brain might lead to differences in brain cell health and communication. Our current questions focus on discovering why some people have high level of Alzheimer’s pathology in their brains, but experience no problems with their memory, and how changes in protein isoforms might lead to the symptoms of schizophrenia.

Our team

Recent publications

What's new

DPAG researchers host week-long teacher residential in collaboration with Oxford Colleges

Five school teachers joined researchers from the Carlyle, Lakhal-Littleton, Mommersteeg, Srinivas, and Stone groups, based in the Institute of Developmental and Regenerative Medicine (IDRM), Kavli Institute for Nanoscience Discovery, and Sherrington Building, in a project run in collaboration with Jesus College and Trinity College between 19 and 22 June 2023.

Becky Carlyle funded by leading dementia research charity to reveal new targets for Alzheimer's

Senior Postdoctoral Research Scientist Dr Becky Carlyle has been awarded a £420K funding boost from Alzheimer’s Research UK.

Related research themes

We host a number of internationally recognised neuroscience groups, with expertise in a wide range of experimental and computational methods.

We host a number of internationally recognised ...