ARUK Senior Research Fellow
Ono Rising Star Award
Proteome complexity in neurodegenerative and neuropsychiatric disease
During our lifetimes, most of us will be personally affected by, or be close to someone with, mental health problems, or to someone who experiences memory problems as they get older. These complicated brain diseases are still poorly understood, probably because their origins lie within a combination of genetic risk, exposure to environmental stressors, and differences in our behaviour, that cause subtle changes to the way our brain cells communicate with each other. These subtle changes, accumulated across a lifespan, lead to the development of the symptoms we experience.
Our research uses a combination of proteomic techniques in post-mortem human brain tissue and experiments in cellular brain cell-models, to understand how protein-level changes in the brain might lead to differences in brain cell health and communication. Our current questions focus on discovering why some people have high level of Alzheimer’s pathology in their brains, but experience no problems with their memory, and how changes in protein isoforms might lead to the symptoms of schizophrenia.
Join the Carlyle Lab
5 July 2023
Five school teachers joined researchers from the Carlyle, Lakhal-Littleton, Mommersteeg, Srinivas, and Stone groups, based in the Institute of Developmental and Regenerative Medicine (IDRM), Kavli Institute for Nanoscience Discovery, and Sherrington Building, in a project run in collaboration with Jesus College and Trinity College between 19 and 22 June 2023.
21 September 2022
Senior Postdoctoral Research Scientist Dr Becky Carlyle has been awarded a £420K funding boost from Alzheimer’s Research UK.