Monoamine transmission: from mechanisms to movement
The neurotransmitter dopamine in the brain is critical to how we choose our everyday actions, by signaling our motivations and selecting appropriate movements. When dopamine function is disrupted, a range of psychomotor disorders can result that include addiction disorders and Parkinson’s disease.
Our work explores how dopamine function is governed and dysregulated through study of dopamine transmission in real-time.
In a range of parallel and intersecting projects, we are exploring:
- Mechanisms on dopamine axons that govern dopamine output
- Circuits that govern dopamine transmission
- Dopamine signalling dysfunctions in Parkinson’s disease
- How drugs of addiction modify dopamine signals
- How dopamine controls behaviour
Please get in touch if you’d like to find out how to join the lab.
Cragg Group Announcements
February 2021 - we are currently recruiting for a Post-doctoral Research Scientist and a graduate Research Assistant to join us on a 3-year project funded by the MRC. See the links for more information and how to apply.
Deadline for applications is March 1st!
Please read our pledge to support inclusivity, diversity and equality here.
Cragg Group News
2 October 2020
A new collaborative study from the Oxford Parkinson’s Disease Centre led by Prof Stephanie Cragg and Dr Bradley Roberts has revealed that GABA transporters on astrocytes, the brain's lesser known yet critically important cells, support dopamine release and are sites of early dysfunction in parkinsonism.
4 November 2019
Our Researchers at the Oxford Parkinson’s Disease Centre have shown that cell recycling in Parkinson’s may play a more complex role than previously thought.
20 September 2019
The release of dopamine in the brain plays a key role in determining how we respond when we perceive a potential reward or benefit. But so far little has been understood about the mechanism behind this. A new collaborative paper from Prof Stephanie Cragg's Group and Prof Ed Mann published in Nature Communications has uncovered a dominant regulator of the dynamics of dopamine output.
Dopamine Club is an informal, lab meeting-style forum that brings dopamine researchers together from across the University to exchange and discuss our different perspectives on dopamine.
Dopamine Club was founded in 2014 to bring together dopamine researchers within the University and promote interactions towards the common goal of understanding dopamine function.
Anyone is welcome to attend, organise and participate in Dopamine Club meetings and we'd like it to be as interactive as possible so if you want to be involved please get in touch (firstname.lastname@example.org, or any of the other contributing groups).
Meetings are held termly, usually on Monday of 8th week, in DPAG. Meetings are chaired by different labs on a rotating basis.
Book Chapters and Other Articles
|Handbook of Basal Ganglia Structure and Function, 2nd Edition|
|Compendium of in Vivo Monitoring in Real-Time Molecular Neuroscience: Fundamentals and Applications v. 1 |
Revisiting dopamine-acetylcholine imbalance in Parkinson’s disease: glutamate co-transmission as an exciting partner in crime
CRAGG S. and Zhang Y-F., (2021), Neuron
Axonal Modulation of Striatal Dopamine Release by Local γ-Aminobutyric Acid (GABA) Signalling.
Roberts BM. et al, (2021), Cells, 10
Striatal dopamine transporter function is facilitated by converging biology of α-synuclein and cholesterol
BRIMBLECOMBE K. et al, (2021), Frontiers in Cellular Neuroscience
GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model.
Roberts BM. et al, (2020), Nat Commun, 11