Stephanie Cragg

• The Striosome and Matrix Compartments of the Striatum: A Path through the Labyrinth from Neurochemistry toward Function.

  Journal article

  Brimblecombe KR. and Cragg SJ., (2017), ACS Chem Neurosci, 8, 235 - 242

• Regulation of Extracellular Dopamine: Release and Uptake

  Chapter

  Sulzer D. et al, (2017), Handbook of Behavioral Neuroscience, 24, 373 - 402

• Cortical Control of Striatal Dopamine Transmission via Striatal Cholinergic Interneurons.

  Journal article

  Kosillo P. et al, (2016), Cereb Cortex

• Striatal dopamine neurotransmission: regulation of release and uptake.

  Journal article

  Sulzer D. et al, (2016), Basal Ganglia, 6, 123 - 148

• Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism.

  Journal article

  Dodson PD. et al, (2016), Proc Natl Acad Sci U S A, 113, E2180 - E2188

• LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function.

  Journal article

  Sloan M. et al, (2016), Hum Mol Genet, 25, 951 - 963

• The impact of a parkinsonian lesion on dynamic striatal dopamine transmission depends on nicotinic receptor activation.

  Journal article

  Jennings KA. et al, (2015), Neurobiol Dis, 82, 262 - 268

• Transcription factors FOXA1 and FOXA2 maintain dopaminergic neuronal properties and control feeding behavior in adult mice.

  Journal article

  Pristerà A. et al, (2015), Proc Natl Acad Sci U S A, 112, E4929 - E4938

• Substance P Weights Striatal Dopamine Transmission Differently within the Striosome-Matrix Axis.

  Journal article

  Brimblecombe KR. and Cragg SJ., (2015), J Neurosci, 35, 9017 - 9023

• Impaired intracellular trafficking defines early Parkinson's disease.

  Journal article

  Hunn BH. et al, (2015), Trends Neurosci, 38, 178 - 188

• Gating of dopamine transmission by calcium and axonal N-, Q-, T- and L-type voltage-gated calcium channels differs between striatal domains.

  Journal article

  Brimblecombe KR. et al, (2015), J Physiol, 593, 929 - 946

• Ni(2+) affects dopamine uptake which limits suitability as inhibitor of T-type voltage-gated Ca(2+) channels.

  Journal article

  Brimblecombe KR. and Cragg SJ., (2015), ACS Chem Neurosci, 6, 124 - 129

• Impaired intracellular trafficking defines early Parkinson's disease

  Journal article

  Hunn BHM. et al, (2015), Trends in Neurosciences, 38, 178 - 188

• COUPLING VOLTAMMETRY WITH OPTOGENETICS TO REVEAL AXONAL CONTROL OF DOPAMINE TRANSMISSION BY STRIATAL ACETYLCHOLINE

  Chapter

  Kosillo P. et al, (2014), Compendium of in Vivo Monitoring in Real-Time Molecular Neuroscience - Volume 1 Fundamentals and Applications, 1, 201 - 223

• Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse.

  Journal article

  Taylor TN. et al, (2014), Neurobiol Dis, 62, 193 - 207

• Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model.

  Journal article

  Janezic S. et al, (2013), Proc Natl Acad Sci U S A, 110, E4016 - E4025

• Nicotinic acetylcholine receptor regulation of striatal dopamine transmission: The different requirement for diverse subtypes in ventral versus dorsal striatum

  Conference paper

  Exley R. et al, (2013), BIOCHEMICAL PHARMACOLOGY, 86, 1228 - 1229

• Striatal dopamine transmission is reduced after chronic nicotine with a decrease in α6-nicotinic receptor control in nucleus accumbens.

  Journal article

  Exley R. et al, (2013), Eur J Neurosci, 38, 3036 - 3043

• Serotonin spillover onto the axon initial segment of motoneurons induces central fatigue by inhibiting action potential initiation.

  Journal article

  Cotel F. et al, (2013), Proc Natl Acad Sci U S A, 110, 4774 - 4779

• Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons.

  Journal article

  Threlfell S. et al, (2012), Neuron, 75, 58 - 64

• Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin.

  Journal article

  Adlam D. et al, (2012), Cardiovasc Res, 93, 694 - 701

• Striatal α5 nicotinic receptor subunit regulates dopamine transmission in dorsal striatum.

  Journal article

  Exley R. et al, (2012), J Neurosci, 32, 2352 - 2356

• Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin

  Journal article

  Adlam D. et al, (2012), Cardiovascular Research, 93, 694 - 701

• Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice.

  Journal article

  Platt NJ. et al, (2012), PLoS One, 7

• Dopamine release in the basal ganglia.

  Journal article

  Rice ME. et al, (2011), Neuroscience, 198, 112 - 137

• Dopamine release in the basal ganglia

  Journal article

  Rice ME. et al, (2011), Neuroscience, 198, 112 - 137

• Nitric oxide donors enhance the frequency dependence of dopamine release in nucleus accumbens.

  Journal article

  Hartung H. et al, (2011), Neuropsychopharmacology, 36, 1811 - 1822

• Nitric oxide donors enhance the frequency dependence of dopamine release in nucleus accumbens

  Journal article

  Hartung H. et al, (2011), Neuropsychopharmacology, 36, 1811 - 1822

• Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family.

  Journal article

  Anwar S. et al, (2011), J Neurosci, 31, 7264 - 7274

• Distinct contributions of nicotinic acetylcholine receptor subunit alpha4 and subunit alpha6 to the reinforcing effects of nicotine.

  Journal article

  Exley R. et al, (2011), Proc Natl Acad Sci U S A, 108, 7577 - 7582

• Dopamine signaling in dorsal versus ventral striatum: The dynamic role of cholinergic interneurons

  Journal article

  Threlfell S. and Cragg SJ., (2011), Frontiers in Systems Neuroscience

• Dopamine signaling in dorsal versus ventral striatum: the dynamic role of cholinergic interneurons.

  Journal article

  Threlfell S. and Cragg SJ., (2011), Front Syst Neurosci, 5

• α-Synuclein and dopamine at the crossroads of Parkinson's disease.

  Journal article

  Venda LL. et al, (2010), Trends Neurosci, 33, 559 - 568

• Non-linear relationship between 5-HT transporter gene expression and frequency sensitivity of 5-HT signals.

  Journal article

  Jennings KA. et al, (2010), J Neurochem, 115, 965 - 973

• Striatal muscarinic receptors promote activity dependence of dopamine transmission via distinct receptor subtypes on cholinergic interneurons in ventral versus dorsal striatum.

  Journal article

  Threlfell S. et al, (2010), J Neurosci, 30, 3398 - 3408

• 5-HT(1B) receptor regulation of serotonin (5-HT) release by endogenous 5-HT in the substantia nigra.

  Journal article

  Threlfell S. et al, (2010), Neuroscience, 165, 212 - 220

• Maintaining network activity in submerged hippocampal slices: importance of oxygen supply.

  Journal article

  Hájos N. et al, (2009), Eur J Neurosci, 29, 319 - 327

• Regulation of Dopamine Release by Striatal Acetylcholine and Nicotine Is via Distinct Nicotinic Acetylcholine Receptors in Dorsal vs. Ventral Striatum

  Conference paper

  Exley R. et al, (2009), BASAL GANGLIA IX, 58, 323 - 335

• Constitutive histamine H2 receptor activity regulates serotonin release in the substantia nigra.

  Journal article

  Threlfell S. et al, (2008), J Neurochem, 107, 745 - 755

• Alpha6-containing nicotinic acetylcholine receptors dominate the nicotine control of dopamine neurotransmission in nucleus accumbens.

  Journal article

  Exley R. et al, (2008), Neuropsychopharmacology, 33, 2158 - 2166

• Dopamine spillover after quantal release: rethinking dopamine transmission in the nigrostriatal pathway.

  Journal article

  Rice ME. and Cragg SJ., (2008), Brain Res Rev, 58, 303 - 313

• Presynaptic nicotinic receptors: a dynamic and diverse cholinergic filter of striatal dopamine neurotransmission.

  Journal article

  Exley R. and Cragg SJ., (2008), Br J Pharmacol, 153 Suppl 1, S283 - S297

• Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein.

  Journal article

  Senior SL. et al, (2008), Eur J Neurosci, 27, 947 - 957

• A choreography of nicotinic receptors directs the dopamine neuron routine.

  Journal article

  Ungless MA. and Cragg SJ., (2006), Neuron, 50, 815 - 816

• Meaningful silences: how dopamine listens to the ACh pause.

  Journal article

  Cragg SJ., (2006), Trends Neurosci, 29, 125 - 131

• Variation in the dynamic probability of dopamine release between limbic- versus motor-associated primate striatum

  Conference paper

  Cragg SJ., (2005), BEHAVIOURAL PHARMACOLOGY, 16, S15 - S15

• Singing to the tune of dopamine. Focus on "Properties of dopamine release and uptake in the songbird basal ganglia".

  Journal article

  Cragg SJ., (2005), J Neurophysiol, 93, 1827 - 1828

• Somatodendritic dopamine release in midbrain

  Chapter

  Cragg SJ. and Rice ME., (2005), Dendritic Neurotransmitter Release, 69 - 83

• Striatal acetylcholine control of reward-related dopamine signalling

  Conference paper

  Cragg SJ. et al, (2005), Basal Ganglia VIII, 56, 99 - 108

• Histamine H3 receptors inhibit serotonin release in substantia nigra pars reticulata.

  Journal article

  Threlfell S. et al, (2004), J Neurosci, 24, 8704 - 8710

• Synaptic release of dopamine in the subthalamic nucleus.

  Journal article

  Cragg SJ. et al, (2004), Eur J Neurosci, 20, 1788 - 1802

• Nicotine amplifies reward-related dopamine signals in striatum.

  Journal article

  Rice ME. and Cragg SJ., (2004), Nat Neurosci, 7, 583 - 584

• DAncing past the DAT at a DA synapse.

  Journal article

  Cragg SJ. and Rice ME., (2004), Trends Neurosci, 27, 270 - 277

• Variable dopamine release probability and short-term plasticity between functional domains of the primate striatum.

  Journal article

  Cragg SJ., (2003), J Neurosci, 23, 4378 - 4385

• Brain antioxidant regulation in mammals and anoxia-tolerant reptiles: balanced for neuroprotection and neuromodulation.

  Journal article

  Rice ME. et al, (2002), Comp Biochem Physiol C Toxicol Pharmacol, 133, 515 - 525

• Functional domains in dorsal striatum of the nonhuman primate are defined by the dynamic behavior of dopamine.

  Journal article

  Cragg SJ. et al, (2002), J Neurosci, 22, 5705 - 5712

• Heterogeneity of dopamine release in the primate striatum

  Conference paper

  Cragg SJ. and Hille CJ., (2002), BASAL GANGLIA VII, 52, 87 - 96

• Dopamine-mediated volume transmission in midbrain is regulated by distinct extracellular geometry and uptake.

  Journal article

  Cragg SJ. et al, (2001), J Neurophysiol, 85, 1761 - 1771

• Dopamine release and uptake dynamics within nonhuman primate striatum in vitro.

  Journal article

  Cragg SJ. et al, (2000), J Neurosci, 20, 8209 - 8217

• Real-time dynamics of dopamine released from neuronal transplants in experimental Parkinson's disease.

  Journal article

  Cragg SJ. et al, (2000), Exp Neurol, 164, 145 - 153

• Dopamine release and uptake kinetics in the putamen of non-human primate striatum in vitro: Species and region differences

  Journal article

  Cragg SJ. et al, (2000), EUROPEAN JOURNAL OF NEUROSCIENCE, 12, 135 - 135

• Dopamine receptors--physiological understanding to therapeutic intervention potential.

  Journal article

  Emilien G. et al, (1999), Pharmacol Ther, 84, 133 - 156

• Dopamine is released spontaneously from developing midbrain neurons in organotypic culture.

  Journal article

  Cragg SJ. et al, (1998), Neuroscience, 84, 325 - 330

• Comparison of serotonin and dopamine release in substantia nigra and ventral tegmental area: region and species differences.

  Journal article

  Cragg SJ. et al, (1997), J Neurochem, 69, 2378 - 2386

• Differential autoreceptor control of somatodendritic and axon terminal dopamine release in substantia nigra, ventral tegmental area, and striatum.

  Journal article

  Cragg SJ. and Greenfield SA., (1997), J Neurosci, 17, 5738 - 5746

• Characteristics of electrically evoked somatodendritic dopamine release in substantia nigra and ventral tegmental area in vitro.

  Journal article

  Rice ME. et al, (1997), J Neurophysiol, 77, 853 - 862

• Heterogeneity of electrically evoked dopamine release and reuptake in substantia nigra, ventral tegmental area, and striatum.

  Journal article

  Cragg S. et al, (1997), J Neurophysiol, 77, 863 - 873

• Pauses in striatal cholinergic interneurons: what is revealed by their common themes and variations?

  Journal article

  Cragg SJ. and Zhang YF., Frontiers in Systems Neuroscience

Key Publications

• Cortical Control of Striatal Dopamine Transmission via Striatal Cholinergic Interneurons.

  Journal article

  Kosillo P. et al, (2016), Cereb Cortex
• Striatal dopamine neurotransmission: regulation of release and uptake.

  Journal article

  Sulzer D. et al, (2016), Basal Ganglia, 6, 123 - 148
• Substance P Weights Striatal Dopamine Transmission Differently within the Striosome-Matrix Axis.

  Journal article

  Brimblecombe KR. and Cragg SJ., (2015), J Neurosci, 35, 9017 - 9023
• Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons.

  Journal article

  Threlfell S. et al, (2012), Neuron, 75, 58 - 64
• Meaningful silences: how dopamine listens to the ACh pause.

  Journal article

  Cragg SJ., (2006), Trends Neurosci, 29, 125 - 131

Recent Publications

• The Striosome and Matrix Compartments of the Striatum: A Path through the Labyrinth from Neurochemistry toward Function.

  Journal article

  Brimblecombe KR. and Cragg SJ., (2017), ACS Chem Neurosci, 8, 235 - 242
• Regulation of Extracellular Dopamine: Release and Uptake

  Chapter

  Sulzer D. et al, (2017), Handbook of Behavioral Neuroscience, 24, 373 - 402
• Cortical Control of Striatal Dopamine Transmission via Striatal Cholinergic Interneurons.

  Journal article

  Kosillo P. et al, (2016), Cereb Cortex
• Striatal dopamine neurotransmission: regulation of release and uptake.

  Journal article

  Sulzer D. et al, (2016), Basal Ganglia, 6, 123 - 148
• Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism.

  Journal article

  Dodson PD. et al, (2016), Proc Natl Acad Sci U S A, 113, E2180 - E2188