Stephanie Cragg

• The Striosome and Matrix Compartments of the Striatum: A Path through the Labyrinth from Neurochemistry toward Function.

  Brimblecombe KR. and Cragg SJ., (2017), ACS Chem Neurosci, 8, 235 - 242

• Regulation of Extracellular Dopamine: Release and Uptake

  Sulzer D. et al, (2017), Handbook of Behavioral Neuroscience, 24, 373 - 402

• Cortical Control of Striatal Dopamine Transmission via Striatal Cholinergic Interneurons.

  Kosillo P. et al, (2016), Cereb Cortex

• Striatal dopamine neurotransmission: regulation of release and uptake.

  Sulzer D. et al, (2016), Basal Ganglia, 6, 123 - 148

• Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism.

  Dodson PD. et al, (2016), Proc Natl Acad Sci U S A, 113, E2180 - E2188

• LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function.

  Sloan M. et al, (2016), Hum Mol Genet, 25, 951 - 963

• The impact of a parkinsonian lesion on dynamic striatal dopamine transmission depends on nicotinic receptor activation.

  Jennings KA. et al, (2015), Neurobiol Dis, 82, 262 - 268

• Transcription factors FOXA1 and FOXA2 maintain dopaminergic neuronal properties and control feeding behavior in adult mice.

  Pristerà A. et al, (2015), Proc Natl Acad Sci U S A, 112, E4929 - E4938

• Substance P Weights Striatal Dopamine Transmission Differently within the Striosome-Matrix Axis.

  Brimblecombe KR. and Cragg SJ., (2015), J Neurosci, 35, 9017 - 9023

• Impaired intracellular trafficking defines early Parkinson's disease.

  Hunn BH. et al, (2015), Trends Neurosci, 38, 178 - 188

• Gating of dopamine transmission by calcium and axonal N-, Q-, T- and L-type voltage-gated calcium channels differs between striatal domains.

  Brimblecombe KR. et al, (2015), J Physiol, 593, 929 - 946

• Ni(2+) affects dopamine uptake which limits suitability as inhibitor of T-type voltage-gated Ca(2+) channels.

  Brimblecombe KR. and Cragg SJ., (2015), ACS Chem Neurosci, 6, 124 - 129

• Impaired intracellular trafficking defines early Parkinson's disease

  Hunn BHM. et al, (2015), Trends in Neurosciences, 38, 178 - 188

• COUPLING VOLTAMMETRY WITH OPTOGENETICS TO REVEAL AXONAL CONTROL OF DOPAMINE TRANSMISSION BY STRIATAL ACETYLCHOLINE

  Kosillo P. et al, (2014), Compendium of in Vivo Monitoring in Real-Time Molecular Neuroscience - Volume 1 Fundamentals and Applications, 1, 201 - 223

• Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse.

  Taylor TN. et al, (2014), Neurobiol Dis, 62, 193 - 207

• Nicotinic acetylcholine receptor regulation of striatal dopamine transmission: The different requirement for diverse subtypes in ventral versus dorsal striatum

  Exley R. et al, (2013), BIOCHEMICAL PHARMACOLOGY, 86, 1228 - 1229

• Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model.

  Janezic S. et al, (2013), Proc Natl Acad Sci U S A, 110, E4016 - E4025

• Striatal dopamine transmission is reduced after chronic nicotine with a decrease in α6-nicotinic receptor control in nucleus accumbens.

  Exley R. et al, (2013), Eur J Neurosci, 38, 3036 - 3043

• Serotonin spillover onto the axon initial segment of motoneurons induces central fatigue by inhibiting action potential initiation.

  Cotel F. et al, (2013), Proc Natl Acad Sci U S A, 110, 4774 - 4779

• Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons.

  Threlfell S. et al, (2012), Neuron, 75, 58 - 64

• Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin.

  Adlam D. et al, (2012), Cardiovasc Res, 93, 694 - 701

• Striatal α5 nicotinic receptor subunit regulates dopamine transmission in dorsal striatum.

  Exley R. et al, (2012), J Neurosci, 32, 2352 - 2356

• Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice.

  Platt NJ. et al, (2012), PLoS One, 7

• Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin

  Adlam D. et al, (2012), Cardiovascular Research, 93, 694 - 701

• Dopamine release in the basal ganglia.

  Rice ME. et al, (2011), Neuroscience, 198, 112 - 137

• Dopamine release in the basal ganglia

  Rice ME. et al, (2011), Neuroscience, 198, 112 - 137

• Nitric oxide donors enhance the frequency dependence of dopamine release in nucleus accumbens.

  Hartung H. et al, (2011), Neuropsychopharmacology, 36, 1811 - 1822

• Nitric oxide donors enhance the frequency dependence of dopamine release in nucleus accumbens

  Hartung H. et al, (2011), Neuropsychopharmacology, 36, 1811 - 1822

• Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family.

  Anwar S. et al, (2011), J Neurosci, 31, 7264 - 7274

• Distinct contributions of nicotinic acetylcholine receptor subunit alpha4 and subunit alpha6 to the reinforcing effects of nicotine.

  Exley R. et al, (2011), Proc Natl Acad Sci U S A, 108, 7577 - 7582

• Dopamine signaling in dorsal versus ventral striatum: The dynamic role of cholinergic interneurons

  Threlfell S. and Cragg SJ., (2011), Frontiers in Systems Neuroscience

• Dopamine signaling in dorsal versus ventral striatum: the dynamic role of cholinergic interneurons.

  Threlfell S. and Cragg SJ., (2011), Front Syst Neurosci, 5

• α-Synuclein and dopamine at the crossroads of Parkinson's disease.

  Venda LL. et al, (2010), Trends Neurosci, 33, 559 - 568

• Non-linear relationship between 5-HT transporter gene expression and frequency sensitivity of 5-HT signals.

  Jennings KA. et al, (2010), J Neurochem, 115, 965 - 973

• Striatal muscarinic receptors promote activity dependence of dopamine transmission via distinct receptor subtypes on cholinergic interneurons in ventral versus dorsal striatum.

  Threlfell S. et al, (2010), J Neurosci, 30, 3398 - 3408

• 5-HT(1B) receptor regulation of serotonin (5-HT) release by endogenous 5-HT in the substantia nigra.

  Threlfell S. et al, (2010), Neuroscience, 165, 212 - 220

• Regulation of Dopamine Release by Striatal Acetylcholine and Nicotine Is via Distinct Nicotinic Acetylcholine Receptors in Dorsal vs. Ventral Striatum

  Exley R. et al, (2009), BASAL GANGLIA IX, 58, 323 - 335

• Maintaining network activity in submerged hippocampal slices: importance of oxygen supply.

  Hájos N. et al, (2009), Eur J Neurosci, 29, 319 - 327

• Constitutive histamine H2 receptor activity regulates serotonin release in the substantia nigra.

  Threlfell S. et al, (2008), J Neurochem, 107, 745 - 755

• Dopamine spillover after quantal release: rethinking dopamine transmission in the nigrostriatal pathway.

  Rice ME. and Cragg SJ., (2008), Brain Res Rev, 58, 303 - 313

• Alpha6-containing nicotinic acetylcholine receptors dominate the nicotine control of dopamine neurotransmission in nucleus accumbens.

  Exley R. et al, (2008), Neuropsychopharmacology, 33, 2158 - 2166

• Presynaptic nicotinic receptors: a dynamic and diverse cholinergic filter of striatal dopamine neurotransmission.

  Exley R. and Cragg SJ., (2008), Br J Pharmacol, 153 Suppl 1, S283 - S297

• Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein.

  Senior SL. et al, (2008), Eur J Neurosci, 27, 947 - 957

• A choreography of nicotinic receptors directs the dopamine neuron routine.

  Ungless MA. and Cragg SJ., (2006), Neuron, 50, 815 - 816

• Meaningful silences: how dopamine listens to the ACh pause.

  Cragg SJ., (2006), Trends Neurosci, 29, 125 - 131

• Variation in the dynamic probability of dopamine release between limbic- versus motor-associated primate striatum

  Cragg SJ., (2005), BEHAVIOURAL PHARMACOLOGY, 16, S15 - S15

• Singing to the tune of dopamine. Focus on "Properties of dopamine release and uptake in the songbird basal ganglia".

  Cragg SJ., (2005), J Neurophysiol, 93, 1827 - 1828

• Striatal acetylcholine control of reward-related dopamine signalling

  Cragg SJ. et al, (2005), Basal Ganglia VIII, 56, 99 - 108

• Somatodendritic dopamine release in midbrain

  Cragg SJ. and Rice ME., (2005), Dendritic Neurotransmitter Release, 69 - 83

• Histamine H3 receptors inhibit serotonin release in substantia nigra pars reticulata.

  Threlfell S. et al, (2004), J Neurosci, 24, 8704 - 8710

• Synaptic release of dopamine in the subthalamic nucleus.

  Cragg SJ. et al, (2004), Eur J Neurosci, 20, 1788 - 1802

• Nicotine amplifies reward-related dopamine signals in striatum.

  Rice ME. and Cragg SJ., (2004), Nat Neurosci, 7, 583 - 584

• DAncing past the DAT at a DA synapse.

  Cragg SJ. and Rice ME., (2004), Trends Neurosci, 27, 270 - 277

• Variable dopamine release probability and short-term plasticity between functional domains of the primate striatum.

  Cragg SJ., (2003), J Neurosci, 23, 4378 - 4385

• Brain antioxidant regulation in mammals and anoxia-tolerant reptiles: balanced for neuroprotection and neuromodulation.

  Rice ME. et al, (2002), Comp Biochem Physiol C Toxicol Pharmacol, 133, 515 - 525

• Functional domains in dorsal striatum of the nonhuman primate are defined by the dynamic behavior of dopamine.

  Cragg SJ. et al, (2002), J Neurosci, 22, 5705 - 5712

• Heterogeneity of dopamine release in the primate striatum

  Cragg SJ. and Hille CJ., (2002), BASAL GANGLIA VII, 52, 87 - 96

• Dopamine-mediated volume transmission in midbrain is regulated by distinct extracellular geometry and uptake.

  Cragg SJ. et al, (2001), J Neurophysiol, 85, 1761 - 1771

• Dopamine release and uptake dynamics within nonhuman primate striatum in vitro.

  Cragg SJ. et al, (2000), J Neurosci, 20, 8209 - 8217

• Real-time dynamics of dopamine released from neuronal transplants in experimental Parkinson's disease.

  Cragg SJ. et al, (2000), Exp Neurol, 164, 145 - 153

• Dopamine release and uptake kinetics in the putamen of non-human primate striatum in vitro: Species and region differences

  Cragg SJ. et al, (2000), EUROPEAN JOURNAL OF NEUROSCIENCE, 12, 135 - 135

• Dopamine receptors--physiological understanding to therapeutic intervention potential.

  Emilien G. et al, (1999), Pharmacol Ther, 84, 133 - 156

• Dopamine is released spontaneously from developing midbrain neurons in organotypic culture.

  Cragg SJ. et al, (1998), Neuroscience, 84, 325 - 330

• Comparison of serotonin and dopamine release in substantia nigra and ventral tegmental area: region and species differences.

  Cragg SJ. et al, (1997), J Neurochem, 69, 2378 - 2386

• Differential autoreceptor control of somatodendritic and axon terminal dopamine release in substantia nigra, ventral tegmental area, and striatum.

  Cragg SJ. and Greenfield SA., (1997), J Neurosci, 17, 5738 - 5746

• Heterogeneity of electrically evoked dopamine release and reuptake in substantia nigra, ventral tegmental area, and striatum.

  Cragg S. et al, (1997), J Neurophysiol, 77, 863 - 873

• Characteristics of electrically evoked somatodendritic dopamine release in substantia nigra and ventral tegmental area in vitro.

  Rice ME. et al, (1997), J Neurophysiol, 77, 853 - 862

Key Publications

• Cortical Control of Striatal Dopamine Transmission via Striatal Cholinergic Interneurons.

  Kosillo P. et al, (2016), Cereb Cortex
• Striatal dopamine neurotransmission: regulation of release and uptake.

  Sulzer D. et al, (2016), Basal Ganglia, 6, 123 - 148
• Substance P Weights Striatal Dopamine Transmission Differently within the Striosome-Matrix Axis.

  Brimblecombe KR. and Cragg SJ., (2015), J Neurosci, 35, 9017 - 9023
• Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons.

  Threlfell S. et al, (2012), Neuron, 75, 58 - 64
• Meaningful silences: how dopamine listens to the ACh pause.

  Cragg SJ., (2006), Trends Neurosci, 29, 125 - 131

Recent Publications

• The Striosome and Matrix Compartments of the Striatum: A Path through the Labyrinth from Neurochemistry toward Function.

  Brimblecombe KR. and Cragg SJ., (2017), ACS Chem Neurosci, 8, 235 - 242
• Regulation of Extracellular Dopamine: Release and Uptake

  Sulzer D. et al, (2017), Handbook of Behavioral Neuroscience, 24, 373 - 402
• Cortical Control of Striatal Dopamine Transmission via Striatal Cholinergic Interneurons.

  Kosillo P. et al, (2016), Cereb Cortex
• Striatal dopamine neurotransmission: regulation of release and uptake.

  Sulzer D. et al, (2016), Basal Ganglia, 6, 123 - 148
• Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism.

  Dodson PD. et al, (2016), Proc Natl Acad Sci U S A, 113, E2180 - E2188