Simon Bossi

I completed my PhD degree in Neuroscience in 2017, at the University of Paris-Saclay in Orsay, France, working under the supervision of Professor Hervé Daniel. My thesis work focused on the study of presynaptic metabotropic glutamate receptors in the rodent cerebellum by electrophysiological, opto-pharmacological and imaging approaches.

To further study glutamate transmission in the rodent brain, in early 2018 I joined the group of Pierre Paoletti at the Biology Institute of the “Ecole Normale Supérieure” in Paris, as a post-doctoral researcher. Between 2018 and 2022 I participated actively in the discovery of a new type of glutamate receptors that are exclusively activated by Glycine, the eGlyRs. Since these receptors can also be modulated by dopamine, I became increasingly interested in the roles of dopamine in health and disease and its possible interplay with glycine.

In January 2023 I joined the group of Prof Stephanie Cragg as a postdoctoral researcher. My work articulates around three major axes: 1) studying how astrocytes participate in striatal circuits and modulate dopamine release, 2) assessing the role of glycine in the striatum, 3) addressing points 1 and 2 on experimental models of Parkinson's disease to determine if and how those mechanism might be altered in disease.