Simon Bossi

I completed my PhD degree in Neuroscience in 2017, at the University of Paris-Saclay in Orsay, France, working under the co-supervision of Professor Hervé Daniel and Dr Heather McLean. My thesis work focused on the study of presynaptic metabotropic glutamate receptors in the rodent cerebellum by electrophysiological, opto-pharmacological and imaging approaches.

To further study glutamate transmission in the rodent brain, in early 2018 I joined the group of Pierre Paoletti at the Biology Institute of the “Ecole Normale Supérieure” in Paris, as a post-doctoral researcher. Between 2018 and 2022 I participated actively in the discovery of a new type of glutamate receptors that are exclusively activated by Glycine, the eGlyRs. Since these receptors can also be modulated by dopamine, I became increasingly interested in the roles of dopamine in health and disease and its possible interplay with glycine.

In January 2023 I joined the group of Prof Stephanie Cragg as a postdoctoral researcher. My work articulates around three major axes: 1) studying how astrocytes participate in striatal circuits and modulate dopamine release, 2) assessing the role of glycine in the striatum, 3) addressing points 1 and 2 on experimental models of Parkinson's disease to determine if and how those mechanism might be altered in disease.

As of April 2025, I hold the position of Career Development Fellow at Christ Church College, where I serve as the Organising Tutor in Biomedical Sciences.