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A story about how α-synuclein changes the comings and goings of dopamine
A summary of Threlfell et al 2021 by senior author Katherine Brimblecombe
Bridging the gap between basic research and people with Parkinson’s
Written by Dr Brimblecombe and Parkinson's UK for Medium Blog
My Primary School Visit for Science Week
Written by Dr Brimblecombe for DPAG Outreach news
Postdoctoral Research Scientist
I have been a member or Prof. Cragg's group since starting my DPhil in 2010, and when I graduated in 2013 I extended my stay as a post-doctoral researcher! I predominantly use fast-scan cyclic voltammetry (FCV) to detect monoamines, especially dopamine with sub-second time resolution in rodent ex-vivo brain slices. To date, my work has focused on investigating the mechanisms controlling dopamine release between striatal sub-territories.
I am particularly interested in how local control of dopamine release differs between striatal sub-territories and how these differences correspond to healthy and disease states of the brain.
I am currently investigating the dynamic relationship between Ca2+ and dopamine release in the dorsal and ventral striatum, which we hope will provide insights into the eitiology and potential treatment options for Parkinson's disease. I have also investigated how dopamine transmission varies between the illusive striosome and matrix sub-territories.
Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol.
Threlfell S. et al, (2021), Front Cell Neurosci, 15
GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model.
Roberts BM. et al, (2020), Nat Commun, 11
Selective vulnerability in α-synucleinopathies.
Alegre-Abarrategui J. et al, (2019), Acta Neuropathol, 138, 681 - 704
Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter.
Condon MD. et al, (2019), Nat Commun, 10
Calbindin-D28K Limits Dopamine Release in Ventral but Not Dorsal Striatum by Regulating Ca2+ Availability and Dopamine Transporter Function.
Brimblecombe KR. et al, (2019), ACS Chem Neurosci, 10, 3419 - 3426