Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Accept all cookies Reject all non-essential cookies Find out more

Contact information


katherine.brimblecombe@dpag.ox.ac.uk


01865 272466, 01865 282692


Oxford Parkinson's Disease Centre

Websites

Research groups

Katherine Brimblecombe

Postdoctoral Research Scientist

I have been a member or Prof. Cragg's group since starting my DPhil in 2010, and when I graduated in 2013 I extended my stay as a post-doctoral researcher!  I predominantly use fast-scan cyclic voltammetry (FCV) to detect monoamines, especially dopamine with sub-second time resolution in rodent ex-vivo brain slices. To date, my work has focused on investigating the mechanisms controlling dopamine release between striatal sub-territories. 

I am particularly interested in how local control of dopamine release differs between striatal sub-territories and how these differences correspond to healthy and disease states of the brain.  

I am currently investigating the dynamic relationship between Ca2+ and dopamine release in the dorsal and ventral striatum, which we hope will provide insights into the eitiology and potential treatment options for Parkinson's disease. I have also investigated how dopamine transmission varies between the illusive striosome and matrix sub-territories.