Postdoctoral Research Scientist
I have been a member or Prof. Cragg's group since starting my DPhil in 2010, and when I graduated in 2013 I extended my stay as a post-doctoral researcher! I predominantly use fast-scan cyclic voltammetry (FCV) to detect monoamines, especially dopamine with sub-second time resolution in rodent ex-vivo brain slices. To date, my work has focused on investigating the mechanisms controlling dopamine release between striatal sub-territories.
I am particularly interested in how local control of dopamine release differs between striatal sub-territories and how these differences correspond to healthy and disease states of the brain.
I am currently investigating the dynamic relationship between Ca2+ and dopamine release in the dorsal and ventral striatum, which we hope will provide insights into the eitiology and potential treatment options for Parkinson's disease. I have also investigated how dopamine transmission varies between the illusive striosome and matrix sub-territories.
Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol.
Threlfell S. et al, (2021), Front Cell Neurosci, 15
GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model.
Roberts BM. et al, (2020), Nat Commun, 11
Selective vulnerability in α-synucleinopathies.
Alegre-Abarrategui J. et al, (2019), Acta Neuropathol, 138, 681 - 704
Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter.
Condon MD. et al, (2019), Nat Commun, 10
Calbindin-D28K Limits Dopamine Release in Ventral but Not Dorsal Striatum by Regulating Ca2+ Availability and Dopamine Transporter Function.
Brimblecombe KR. et al, (2019), ACS Chem Neurosci, 10, 3419 - 3426