Past OPDC Seminar Series
Dr Wilma van de Berg, Amsterdam UMC
"Tales from the human brain: a multi-scale approach to elucidate pathogenic mechanisms involved in Parkinson’s"
Dr Emmanouil Metzakopian, UK Dementia Research Institute (UK DRI), University of Cambridge
"CRISPR-Cas9 genetic screens to ameliorate cellular stress in neurodegeneration"
Dr Nicolas Tritsch, (Neuroscience Institute and Marlene & Paulo Fresco Institute for Parkinson’s & Movement Disorders, New York University)
"Modulation of striatal circuits by midbrain dopamine neurons"
Matthew LaVoie, Brigham and Women's Hospital & Harvard Medical School
"Proteostasis and Mitochondrial Pathways in the Pathogenesis and Treatment of Parkinson’s Disease"
Michael Ward, National Institute of Neurological Disorders and Stroke (NINDS)
"Combining iPSCs and ‘omics to identify molecular convergence in neurodegenerative disorders"
Hélène Plun-Favreau, UCL Institute of Neurology
"Mitophagy: from genetics to biology, and back"
Daniel Otzen, Interdisciplinary Nanoscience Center (iNANO), Aarhus University
"Targeting cytotoxic alpha-synuclein oligomers in Parkinson’s Disease"
Vincenzo Bonifati, Erasmus University Medical Center, Rotterdam
"An update on the quest for genetic determinants in Parkinson’s Disease & related diseases"
Tim Bartels, UK Dementia Research Institute (DRI), University College London (UCL)
"Selective brain region vulnerability in Parkinson’s Disease is governed by α-Synuclein conformations"
Madeline Lancaster, MRC, Laboratory of Molecular Biology, Cambridge
"Exploring human brain structure and function using cerebral organoids"
Jacqueline Burré, Brain and Mind Research Institute at Weill Cornell Medicine, USA
"Function and Dysfunction of Synucleins – Membranes Matter"
D. James Surmeier, Feinberg School of Medicine at Northwestern University, USA
"Time to revise the classical model of basal ganglia dysfunction in PD: New insights from a novel, progressive mouse of mitochondrial complex I dysfunction"
Valina Dawson, John Hopkins University School of Medicine, Baltimore, Maryland, USA
"Decoding Parkinson’s Disease: New Therapeutic Opportunities"
Richard Youle, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, Maryland, USA
"Mechanisms of Innate Immunity and Parkinson’s Disease"
Elisa Greggio, Department of Biology, University of Padova
"Molecular pathways to Parkinson's disease: more than neurons?"
UCL School of Pharmacy, "LRRK2 Mediated Cellular Function from Vesicular Trafficking to Gene Expression"
Darren Moore, Center for Neurodegenerative Science, Van Andel Research Institute
"Pathway to Parkinson’s Disease: A Tale of Two Genes"
Mart Saarma, University of Helsinki
"Unconventional Endoplasmic Reticulum Located Trophic Factor for Parkinson’s Disease"
Sonia Gandhi, UCL Queen Square Institute of Neurology
"The toxic consequences of protein aggregation in Parkinson's disease"
Austen Milnerwood, The Neuro, McGill University
"The Quest for Neuroprotection in Parkinson’s disease: reversing synaptic dysfunction"
Esther Sammler, University of Dundee
"Interrogating LRRK2 kinase pathway in human bio-samples in Parkinson’s disease"
Michael Coleman, Department of Clinical Neurosciences, University of Cambridge
"Mechanisms of axon degeneration in injury and disease"
Paolo Calabresi, University of Perugia, Italy
"Striatal synaptic dysfunction in Parkinson's disease"
Ellen Sidransky, National Human Genome Research Institute, NIH
"The magic in the web of it: How a rare disorder is helping to untangle the mysteries of Parkinson’s disease"
Evrando Fei Fang, University of Oslo
"NAD+ and Mitophagy in Brain Ageing and Neurodegenerative Disorders"
Jerome Baufreton, Laboratory of Synaptic and Cellular Dynamics of Neuronal Networks, The Neuroscience Institute at Bordeaux
"Synaptic alterations in the indirect-pathway of the basal ganglia in experimental Parkinsonism"
Gary Miller, Rollins School of Public Health, Emory University
"Parkinson's disease: environmental clues and transporter blues"
Pierre-Herve Luppi, Centre de Recherche en Neurosciences de Lyon
"REM Sleep Behaviour Disorder: from circuits to pathology"
Emily Osterweil, Edinburgh University
"Cell type-specific translation profiling in fragile X"
Malú Tansey, Emory University School of Medicine
"Immune and inflammatory mechanisms underlying risk for age-related neurodegenerative disease"
Stéphane Palfi, Mondor Biomedical Research Institute
"Gene therapies for Parkinson's disease"
Andy West, University of Alabama at Birmingham
"Achieving Neuroprotection in Parkinson’s Disease"
Vladyslav Vyazovskiy, Department of Physiology, Anatomy and Genetics, University of Oxford
"Local and global facets of sleep regulation"
Hélène Plun-Favreau, UCL Institute of Neurology
"Mitophagy modulation as a potential therapeutic target for neurodegenerative diseases"
Barbara Picconi, Lab Neurofisiologia Sperimentale, Università Telematica San Raffaele
Mina Ryten, Institute of Neurology, University College London
Sonja Scholz, Neurodegenerative Diseases Research Unit, NIND, NIH
Professor Olaf Horst, Rieß Institute of Medical Genetics and Applied Genomics, University of Tübingen
Dr Kostas Vekrellis, Biomedical Research Foundation Academy Of Athens
Professor Beate Ritz, School of Public Health at UCLA
Professor Hilal Lashuel, Brain Mind Institute. Swiss Federal Institute of Technology Lausanne
Professor Omar El-Agnaf, Qatar Biomedical Research Institute
Professor Steven Finkbeiner, Gladstone Institute of Neurological Disease/UCSF
Dr Michela Deleidi, Hertie Institute,University of Tübingen
Dr Kathleen Maguire-Zeiss, Georgetown University
Dr Mattia Volta, European Academy of Bolzano/Bozen (EURAC)
Dr Brit Mollenhauer, University Medical Center, Goettingen
Donato Di Monte, German Center for Neurodegenerative Diseases (DZNE)
Professor Dario Alessi, MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee
Professor Miquel Vila, Vall d’Hebron Research Institute (Barcelona)
Professor Malin Parmar, Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, Lund University (Sweden)
Professor Robert Edwards, Department of Neurology, Graduate Program in Biomedical Sciences, University of California, (San Francisco)
Dr Valerio Zerbi, Department of Health Sciences and Technology ETH Zurich (Switzerland)
Professor Jia-Yi Li, Neural Plasticity and Repair group, Department of Experimental Medical Science, Lund University (Sweden)
Dr Mark Cooper, UK Parkinson’s Disease Consortium, UCL Institute of Neurology, University College London
Professor John Reynolds, Brain Research New Zealand/Dept of Anatomy, University of Otago Medical School
Dr Alastair Noyce, Institute of Neurology, University College London
Mickael Decressac, Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy
Professor Nick Allen, School of Biosciences, University of Cardiff
Professor Rejko Krueger, University of Luxembourg
"Patient-based cellular models and stratified treatment options for Parkinson’s disease"
Professor Gilberto Fisone, Karolinska Institute
"Targeting abnormal signalling in experimental Parkinsonism and L-DOPA-induced dyskinesia"
Professor Alice Chen-Plotkin, University of Pennsylvania
"Unbiased Approaches to Parkinson's Disease Biomarker Discovery"
Professor Steven Gill, North Bristol NHS Trust, University of Bristol
"GDNF: Back to the Clinic"
Professor Giovanna Mallucci, University of Cambridge
"Neurodegeneration: molecules to medicines"
Dr Max Little, Aston University
"Detecting Parkinson’s by voice analysis"
Professor Anthony Schapira, Institute of Neurology, University College London
"Glucocerebrosidase in Parkinson disease: insights into aetiology and potential therapies"
Dr Sabine Hilfiker, Institute of Parasitology and biomedicine
"Unravelling the pathogenic roles of LRRK2 in Parkinson’s disease"
Professor Thomas Gasser, University of Tübingen
"Genetic architecture of Parkinson’s disease"
Dr Patrick Lewis, Reading University
"Understanding LRRK2 – from cellular function to human disease"
Professor Ralph Nixon, New York University School of Medicine/Nathan Kline Institute
"Lysosomes: the Achille's heel of neurons in neurodegenerative disease"
Professor Paola Piccini, Imperial College London
"Pre- and post-synaptic mechanisms in L-dopa-induced dyskinesia: evidence from functional imaging"
Professor Matt Farrer, University of British Columbia
"Parkinsonism: etiology, pathogenesis and pathology from a genetic perspective"
Professor David Brooks, Department of Medicine, Imperial College London
"Functional Imaging in Parkinson’s Disease"
Professor Nicholas Wood, Institute of Neurology, University College London
"Genetics of Parkinson’s disease: implications for functional follow up"
Dr Edward Fon, Montreal Neurological Institute, McGill University
"Function of Parkinson's Disease Genes in Mitochondrial Quality Control"
Professor Christine Klein, Department of Neurology, University of Luebeck
"Modeling genetic and idiopathic Parkinson's disease with induced pluripotent stem (iPS) cell-derived neurons"
Dr Erwan Bezard, Institut des Maladies Neurodégénératives, Université Victor Segalen Bordeaux 2
"Peculiar behavior of D1 dopamine receptor in 1-dopa induced dyskinesia"
Dr Nin Bajaj, National Parkinson Foundation Centre of Excellence in Parkinson’s Disease, University of Nottingham
"3T and 7T MRI studies in Parkinson’s disease: some recent advances"
Professor David Sulzer, Departments of Neurology and Psychiatry, Columbia University Medical Centre
"The dopamine synapse in normal function and disease"
Dr Antonio Pisani, Department of Neuroscience, University of Rome Tor Vergata
"Relevance of the striatal cholinergic system in basal ganglia function and dysfunction"
Dr Kelvin Luk, Center for Neurodegenerative Disease Research, University of Pennsylvania
"Propagation of misfolded alpha-synuclein: implications for Parkinson’s disease"
Dr Manju Kurian, Institute of Child Health, University College London
"Dopamine Dyshomeostasis in Childhood Neurological Syndromes"
Professor Ole Isacson, Harvard Medical School, Center for Neuroregeneration Research, McLean Hospital
"Rethinking Parkinson’s disease science and regenerative treatments"
Professor Tamas Revesz, University College London
"Progression of neuropathology in Parkinson’s Disease"
Dr Oliver Bandmann, Sheffield Institute of Translational Neuroscience, University of Sheffield
"New strategies to identify disease – modifying treatment for Parkinson’s Disease"
Dr Huaibin Cai, National Institute on Ageing, NIH, USA
"Molecular determinants of dopaminergic neuron loss in Parkinson’s Disease"
Dr Kostas Vekrellis, Biomedical Research Foundation, Athens, Greece
"In vivo assessment of alpha-synuclein secretion. Possible therapeutic implications in Parkinson’s Disease"
Dr Clive Svendsen, Cedars-Sinai Regenerative Medicine Institute, Los Angeles, USA
'“Disease in a dish”: A new era for modelling human neurological disorders with stem cells'
Professor Birgit Liss, Institute of Applied Physiology, University of Ulm, Germany
"Distinct functions and fates of dopamine midbrain neurons in health and Parkinson's Disease - a tale of two ion channels?"
Dr Tiago Outeiro, Cell and Molecular Neuroscience Unit, Faculdade de Medicina de Lisboa, Portugal
"From the baker to the bedside: unraveling the molecular basis of Parkinson’s Disease"
Professor Kevin Morgan, Faculty of Medicine & Health Sciences, University of Nottingham
"Biomarker discovery in Alzheimer's disease-myth or reality?"
Professor Uwe Walter, Department of Neurology, University of Rostock
"Value of transcranial sonography in the diagnosis and treatment of Parkinson's disease"
Dr Tilo Kunath, Centre for Regenerative Medicine, University of Edinburgh
"Modelling synucleinopathies with human pluripotent stem cells"
Professor Masud Husain, Nuffield Department of Clinical Neurology and Department of Experimental Psychology, University of Oxford
"Inattention, Impulsivity and Apathy in Parkinson's disease"
Dr Nick Allen, School of Biosciences, Cardiff University
"Stem cell-derived neuronal models to study Huntington's disease"
Professor Ola Söderberg, Department of Immunology, Genetics and Pathology, Uppsala University
"Analysis of signaling network activity at a single cell level"
Professor Tipu Aziz, Oxford Functional Neurosurgery, University of Oxford
"Pedunculopontine nucleus stimulation for the treatment of drug resistant freezing and falls in Parkinson’s Disease"
Dr Maeve Caldwell, School of Clinical Sciences, University of Bristol
"Stem cell therapy for Parkinson’s Disease, lessons from the developing brain"
Professor Paul Matthews, GSK Clinical Imaging Centre, Imperial College, London
"The Challenge of Imaging Neurodegeneration in Parkinson’s Disease"
Professor Howard Federoff, Georgetown University Medical Center
"Systems Neuromedicine & Parkinson’s Disease"
Professor Margaret Rice, Department of Neurosurgery, New York University School of Medicine
"How H2O 2 mediates and modulates neurotransmission in the basal ganglia"
Alex Green, Oxford Functional Neurosurgery
"Pendunculopontine nucleus stimulation for the treatment of drug resistant freezing and falls in Parkinson’s Disease"
Professor Yoav Ben-Shlomo, Department of Social Medicine, University of Bristol
"Epidemiological insights into the understanding of Parkinson’s Disease"
Professor Alfred Goldberg, Department of Cell Biology, Harvard University
"Functions of the Proteasome: from clearing misfolded proteins to cancer therapy"
Dr Vania Broccoli, Stem Cells and Neurogenesis Unit, San Raffaele Scientific Institute, Milan
"Generating iDA neuronal cells by direct reprogramming of mouse and human fibroblasts without pluripotent cell intermediates"
Dr Roger Barker, Department of Clinical Neurosciences, University of Cambridge
"The Hetrogeneity of Parkinson’s Disease – its basis and therapeutic implications"
Professor John Hardy, Department of Neurology, Reta Lila Weston Institute of Neurological Studies
"Genetic anaylsis of neurodegeneration"
Professor Patrik Brundin, Lund University, Sweden
Professor Julie Williams, Department of Psychological Medicine and Neurology, Cardiff University School of Medicine
"Defining the Genetic Architecture of Alzheimer's Disease"
Dr Huw Morris, Department of Psychological Medicine and Neurology, Cardiff University School of Medicine
"Clinical and Genetic Analysis of Early Onset Parkinson's Disease"
Dr Andrew Singleton, National Institute on Aging, NIH, USA
"Identifying and Understanding the Genetic Basis of Parkinson’s Disease"
Professor Steve Dunnett, Cardiff School of Biosciences, Cardiff University Functional Mechanisms of Repair and Recovery by Ventral Mesencephalic Tansplants in the Striatum
Professor Robin Franklin, Cambridge Centre for Brain Repair, University of Cambridge CNS remyelination: from biology to therapy
Professor David Burn, Clinical Ageing Research Unit, Newcastle University Dementia in Parkinson’s Disease: What’s new?