DPhil Student in Cardiovascular Science
I am a BHF-funded DPhil student supervised by David Paterson and Ana Domingos, intercalating this research between my pre-clinical and clinical medical studies at Oxford. My interests are with systems physiology, cardiac science and immunology.
Many cardiovascular diseases including essential hypertension, heart failure and post-myocardial infarction are characterised by over-activation of the sympathetic nervous system (the 'fight or flight' component). This leads to a range of harmful consequences, and in hypertension it may drive the blood pressure elevation itself, the sympathetic phenotype being observed patients before overt haemodynamic changes.
I am examining this phenomenon in a model of essential hypertension, focusing in particular on a possible role of the immune system in driving the sympathetic hyperactivity. I currently utilise flow cytometry, cell culture, molecular biology and fluorescent imaging techniques in order to do so.