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Ana Domingos

Associate Professor of Neuroscience

  • Tutor of Medicine at Lady Margaret Hall
  • OUI Innovation Champion

The Domingos laboratory researches neuroimmune mechanisms underlying obesity. They discovered the sympathetic neuro-adipose junction, a functional synapse-like connection between white adipocytes and the sympathetic nervous system (Cell 2015). They found that this neuro-adipose junction is necessary and sufficient for fat mass reduction via norepinephrine (NE) signaling (Cell 2015, Nature Comm 2017). They then discovered Sympathetic neuron-Associated Macrophages (SAMs) that directly import and metabolize NE. Abrogation of SAM function promotes long-term amelioration of obesity independently of food intake (Nature Medicine, 2017).

About Ana's Work on Obesity

© Lady Margaret Hall / Dominik Osvald /

Optogenetics in NeuroImmunity

Speaking at

MRC London Institute of Medical Sciences, Inter-organ Communication in Health and Disease Virtual Symposium, November 24 2020, Session 1: ‘Signalling stress and disease’ 2:20 – 2:30 pm. Register here.

Keystone Symposia, Integrating Metabolism and Immunity, Colorado, USA, January 24 - 28 2021. See programme here.

GRC, Neuroimmunology in Organismic Function: Shared Mechanisms and Reciprocal Interactions, California, USA, January 24 - 29 2021.

Keystone Symposia, Obesity: From Cell to Patient, Vancouver, Canada, January 29 - February 2 2021.

GRC, Gordon Research Conference: Immune System in Health, Disease and Therapy, Castelldefels, Spain, Postponed to 2022.

Key publications

More publications