Search results (123)
« Back to NewsReducing fat in the diabetic heart could improve recovery from heart attack
29 July 2021
Heather Group News Publication Research
New research from the Heather Group has shown that in type 2 diabetes an overload of lipids reduces the heart’s ability to generate energy during a heart attack, decreasing chances of recovery.
The brain’s one-sided teaching signals
16 July 2021
A new study by the Lak group reveals a novel facet of dopamine signalling during visual decision making.
The future of stroke treatment
5 July 2021
Publication Research Wade-Martins Group News
A team of international collaborators including DPAG's Dr Mootaz Salman has been researching a promising new therapeutic for the treatment of strokes and other brain injuries.
New review reveals proof of concept for an anti-obesity immunotherapy
2 July 2021
The Domingos lab has published a new opinion piece in Science investigating the implications of a Memorial Sloan Kettering Cancer Center study that lays the foundations for a potential new anti-obesity treatment in the form of targeting adipose tissue-resident macrophages.
New pathway established for multisensory cortical communication
28 June 2021
Integration of information across the senses is critical for perception. This activity is thought to arise primarily from connections made in the brain's sensory cortical areas. A new paper from the King Group uncovers evidence for the first time on the little understood role of subcortical circuits in shaping the multisensory properties of primary cortical neurons.
Iron deficiency anaemia in early pregnancy increases risk of heart defects, suggests new research
8 June 2021
Cardiac Theme Postdoctoral Publication Research
In animal models, iron deficient mothers have a greatly increased risk of having offspring with congenital heart disease (CHD). The risk of CHD can be greatly reduced if the mother is given iron supplements very early in pregnancy. Additionally, embryos from a mouse model of Down Syndrome were particularly vulnerable to the effects of maternal iron deficiency, leading to a higher risk of developing severe heart defects.
New target to develop immunosuppressants
18 May 2021
A new study from the Parekh Group has resolved a long-standing question in our understanding of intracellular Ca2+ signalling, namely how a specific type of Ca2+ channel is uniquely able to signal to the nucleus to regulate gene expression. By unravelling this mechanism, researchers have identified a new approach for developing immunosuppressant drugs.
How the kidney contributes to healthy iron levels and disease
17 May 2021
Lakhal-Littleton Group News Publication Research
A new study from the Lakhal-Littleton Group has addressed a long-standing gap in our understanding of systemic iron homeostasis. It provides the first formal demonstration that the hormone hepcidin controls iron reabsorption in the kidney, in a manner that impacts the body’s iron levels, under normal physiological conditions. It also demonstrates for the first time how this mechanism becomes critically important in the development of iron disorders.
New research to radically alter our understanding of synaptic development
14 April 2021
A new study from the Molnár group on the role of regulated synaptic vesicular release in specialised synapse formation has made it to the cover of Cerebral Cortex.
Being "in the zone": how waking activity controls sleep need
7 April 2021
Publication Research Vyazovskiy Group News
A new study from the Vyazovskiy group suggests that how and where we spend our time while awake impacts how much we need to sleep - it does not only depend on how long we are awake.
New target identified to develop treatment for Abdominal Aortic Aneurysm
30 March 2021
Cardiac Theme Publication Research
A new study from the Smart group has shed light on a key regulatory step in the initiation and progression of Abdominal Aortic Aneurysm by revealing the protective role of a previously little known small protein.
Researcher publishes children's book of the brain
4 March 2021
Betina Ip, a Royal Society Dorothy Hodgkin Research Fellow based in NDCN, formerly a postdoctoral research scientist in DPAG, has written a book for children: The Usborne Book of the Brain and How it Works.
Same genome, different worlds: How a similar brain causes sexually dimorphic behaviours
27 January 2021
CNCB Goodwin Group News Publication Research
A new paper from the Goodwin group based in DPAG's Centre for Neural Circuits and Behaviour has shown how males and females are programmed differently in terms of sex.
New form of gift wrap drives male reproductive success
26 January 2021
Publication Research Wilson Group News
The transfer of complex mixtures of signals and nutrients between individuals is a key step in several biologically important events in our lives, such as breastfeeding and sexual intercourse. However, we know relatively little about the ways in which the molecular gifts involved are packaged to ensure their successful delivery to the recipient.
Just over half of British Indians would take COVID vaccine
21 January 2021
EDI News Outreach Postdoctoral Publication Research Riley Group News
University of Oxford researchers from the Department of Physiology, Anatomy and Genetics (DPAG) and the Department of Psychiatry, in collaboration with The 1928 Institute, have published a major new study on the impact of COVID-19 on the UK’s largest BME population.
Earliest origins of the forming heart identified
8 January 2021
Cardiac Theme Postdoctoral Publication Research
The earliest known progenitor of the outermost layer of the heart has been characterised for the first time and linked to the development of other critical cell types in the developing heart in a new paper from the Srinivas group led by BHF Immediate Fellow Dr Richard Tyser.
A clue to how a memory-enhancing pill might work
27 November 2020
Hundreds of dietary supplements have been reported to improve cognitive and emotional function in humans, but few have scientific foundation. A new study from the Waddell group provides fresh insight into how dietary Magnesium supplementation can influence memory performance.
New MRI technique could detect early signs of heart failure in cancer patients following chemotherapy
19 November 2020
Cardiac Theme Postdoctoral Publication Research
New research led by Oxford BHF CRE Intermediate Transition Fellow Dr Kerstin Timm shows that a recently developed imaging technique pioneered by the Tyler Group can detect early metabolic changes in the heart caused by a commonly used chemotherapy drug, which is known to increase risk of heart failure in cancer survivors.
Researchers reveal surprising simplicity behind our ability to hear
23 October 2020
Postdoctoral Publication Research Students
A computational modelling study from the King Group demonstrates that the way sounds are transformed from the ear to the brain’s auditory cortex may be simpler than expected. These findings not only highlight the value of computational modelling for determining the principles underlying neural processing, but could also be useful for improving treatments for patients with hearing loss.
New insights into mitochondria quality control could hold the key to treating metabolic disorders
21 October 2020
The Zaccolo Group has identified a new mechanism that regulates mitochondria quality control, a process that is crucial to maintaining healthy cells and preventing disease.