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Neuronal representation of economic decision variables is structured at multiple scale: it exhibit distinct spatial gradients across the frontal cortex, and also depends on where frontal neurons project.

A structured, multi-scale neuronal code for economic decisions

17 October 2025

The scar in a control mouse heart (CON; left panel) and macrophage-specific collagen type V knock-out mouse (cKO; right panel) 21 days after a heart attack. The blue staining highlights aligned and stable collagen fibres in the control heart and highly disorganised, unstable “wavy” collagen fibres in the knock-out heart after injury.

Research shows Type V collagen from macrophages regulates initial collagen assembly and alignment in post-infarcted hearts

10 October 2025

red on black image showing A developing mouse heart at E18.5 (just before birth) showing the coronary blood vessels in red (stained with an antibody to endomucin) and the lymphatic vessels and tissue resident macrophages in white (stained with an antibody to Lyve-1).

Research demonstrates that Cardiac lymphatics retain LYVE-1-dependent macrophages during neonatal mouse heart regeneration

10 October 2025

Review article published: Multimodal, device-based therapeutic targeting of the cardiovascular autonomic nervous system

2 October 2025

photo of Peruvian mountains and city

Oxford and Cayetano win Wellcome Discovery Award to transform care for Chronic Mountain Sickness

30 September 2025

Oxford University researchers pioneer new breathing test to detect lung disease earlier

25 September 2025

A new project led by Oxford University aims to develop a novel breathing test that could detect asthma and COPD earlier, more accurately, and closer to home - reducing pressure on the NHS and improving outcomes for patients.

The image shows a coronal section of an embryonic mouse brain with the Galectin-3 protein removed, visualized with immunofluorescence. The cortical neurons (pictured in red and yellow) showcase an emerging groove. The loss of Gal-3 induces abnormal gyrification, or brain tissue folding, in otherwise smooth cortices.

New research identifies Galectin-3 as a key regulator of neural development, establishing its contribution to brain growth

5 September 2025

Professor Ana Domingos awarded a Royal Society Leverhulme Trust Senior Research Fellowship

29 August 2025

AI segmentation on skeletal muscle

AI-assisted Annotations for Histology

9 August 2025

Expression of the Alzheimer’s-associated Aβ-peptide disrupts the normal aggregation of proteins inside secretory compartments.

Two fly cells (each outlined by a white-dashed line) with about 10 secretory compartments, normally characterised by a central dense-core granule containing aggregated proteins (green; left-hand cell). Aβ-peptide expression disrupts this process (right-hand cell). Magenta staining indicates acidic compartments and ‘n’ the nuclei of these binucleate cells.

Researchers Identify New Mechanism Linked to Early Cellular Defects in Alzheimer’s Disease

18 July 2025

Picasso’s sleeping ‘Woman with Yellow Hair’ (1931) becomes an arrangement of mitochondrial shapes. In a new study in Nature, Raffaele Sarnataro, Gero Miesenböck and colleagues identify mitochondrial electron flux as the root cause of sleep.

Why do we need sleep? Oxford researchers find the answer may lie in mitochondria

16 July 2025

A New study uncovers how a metabolic “overload” in specialised brain cells triggers the need to sleep. Sleep may not just be rest for the mind - it may be essential maintenance for the body’s power supply.

New research shows cortical layers implement AI-like predictive learning

11 July 2025

Soft microrobots bring precision drug delivery closer to clinical reality

10 July 2025

Illustration showing Baseline serum ferritin predicts myocardial iron uptake following intravenous iron therapy – a hypothesis‐generating study

Lakhal-Littleton Group's latest research on intravenous iron therapy is published in the European Journal of Heart Failure

18 June 2025

Professor Ana Domingos one of seven Oxford academics awarded European Research Council Advanced Grants

17 June 2025

BHF Fellowship Awarded to Explore the Hidden Role of Placental Blood Vessels in Pregnancy and Fetal Heart Health

17 June 2025

photo of Mootaz Salman smiling

Dr Mootaz Salman awarded £1.5M BHF/ UK DRI Group Leader position to advance research on the blood-brain barrier in dementia and neurodegeneration

13 June 2025

(left panel) transient expression of the serotonin transporter alongside increased REM sleep buffers cortical serotonin levels in the developing brain with (central panel) serotonin signalling only observed in response to aversive stimuli such as an air puff. (Right panel) dosing with SSRIs in early life can have long-term detrimental consequences for sensory-evoked neural activity with hyperactivity observed in animal exposed to the anti-depressant.

Butt Lab publish a study in Nature Communications on how changes in serotonin signalling affect perinatal brain development

12 June 2025

Longitudinal tracking of long-term learning behaviour and striatal dopamine revealed that dopamine teaching signals shape individuals’ diverse yet systematic learning trajectories, captured mathematically by a deep neural network.

New Lak Lab paper published in Cell: dopamine signals for long-term learning

11 June 2025

an illustration showing Mechanism that drives excess fatty acid metabolism in diabetes involves a FoxO1-zDHHC4-CD36 S-acylation axis.

Paper published by Heather Group in Circulation Research identifies a new metabolic axis which explains why the diabetic heart becomes fatty

9 June 2025

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