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Optical Control of Neurons; Neuronal Control of Behaviour

Optogenetic control: a light beam is used to write information to nerve cells in the brain
Optogenetic control: a light beam is used to write information to nerve cells in the brain

For every mobile organism, life is a string of choices: to stay or go, approach or avoid, stay awake or fall asleep, pay attention or let the mind drift.

The Miesenböck group studies how the brain makes choices. We investigate how neurons represent and distinguish the available alternatives; how options are valued on the basis of instinct or remembered experience; how decisions evolve toward commitment; and how commitment leads to action.

All of this work is done in fruit flies, where it is possible to gain detailed insight into molecular, cellular, and physiological mechanisms of brain function that relate directly to human health.

The group is renowned for many technological innovations, including the invention of optogenetics, the development of genetically encoded probes for imaging neuronal activity, and the construction of automated systems for high-resolution measurement of individual behaviour.

We are based in the Centre for Neural Circuits and Behaviour.

Our team

Selected publications

Operation of a homeostatic sleep switch.

Journal article

Pimentel D. et al, (2016), Nature, 536, 333 - 337

FoxP influences the speed and accuracy of a perceptual decision in Drosophila.

Journal article

DasGupta S. et al, (2014), Science, 344, 901 - 904

Sparse, decorrelated odor coding in the mushroom body enhances learned odor discrimination.

Journal article

Lin AC. et al, (2014), Nat Neurosci, 17, 559 - 568

Neuronal machinery of sleep homeostasis in Drosophila.

Journal article

Donlea JM. et al, (2014), Neuron, 81, 860 - 872

Odor discrimination in Drosophila: from neural population codes to behavior.

Journal article

Parnas M. et al, (2013), Neuron, 79, 932 - 944

Writing memories with light-addressable reinforcement circuitry.

Journal article

Claridge-Chang A. et al, (2009), Cell, 139, 405 - 415

The optogenetic catechism.

Journal article

Miesenböck G., (2009), Science, 326, 395 - 399

Remote control of behavior through genetically targeted photostimulation of neurons.

Journal article

Lima SQ. and Miesenböck G., (2005), Cell, 121, 141 - 152

Related research themes

We host a number of internationally recognised neuroscience groups, with expertise in a wide range of experimental and computational methods.
Neuroscience

We host a number of internationally recognised ...