Lukas B. Krone
Wellcome Trust Doctoral Student in Neuroscience
My research aims at understanding the interaction of global and local sleep regulatory mechanisms. Sleep is traditionally considered as a global behavioral state providing a window for energy conservation, memory consolidation, and various restorative processes especially in the brain. However, recent studies evidence that individual brain areas can briefly switch off during wakefulness and local differences in the depth of sleep occur depending on the use of local brain areas during prior wakefulness. Neuronal mechanisms underlying this fine scale regulation of sleep as well as the crosstalk between local and global sleep regulatory systems are poorly understood. The goal of my project is to identify network components, which are crucial for the generation of local sleep and mediate its putative influence on sleep as a global behavioural state.
A role for the cortex in sleep-wake regulation
Krone LB. et al, (2020), bioRxiv
Sleep, insomnia, and depression.
Riemann D. et al, (2020), Neuropsychopharmacology, 45, 74 - 89
Selective silencing of layer 5 pyramidal neurons increases wake time and affects local and global sleep homeostasis
KRONE L. et al, (2019)
Sleep spindle quality reflects spatio-temporal dynamics of oscillatory activity within cortical networks
Blanco-Duque C. et al, (2019)
Differential effects of bifrontal tDCS on arousal and sleep duration in insomnia patients and healthy controls
Frase L. et al, (2019), Brain Stimulation, 12, 674 - 683