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Drug could help diabetic hearts recover after a heart attack

Cardiac Theme Heather Group News Publication Research

New research led by Associate Professor Lisa Heather has found that a drug known as molidustat, currently in clinical trials for another condition, could reduce risk of heart failure after heart attacks.

DPAG Researchers honoured for their work in cardiac metabolism

Awards and Honours Cardiac Theme EDI News Heather Group News Students

Kaitlyn Dennis, Ujang Purnama and Kerstin Timm have won prizes across each of the three award categories at this year’s Society for Heart and Vascular Metabolism conference, demonstrating DPAG's continued excellence in cardiac metabolism research.

Richard Tyser and Jack Miller honoured by the British Society of Cardiovascular Research

Awards and Honours Cardiac Theme Postdoctoral Srinivas Group news

Dr Richard Tyser is this year’s winner of the Bernard and Joan Marshall Early Career Investigator Prize, and Dr Jack Miller has received a runner-up award, at the British Society of Cardiovascular Research Autumn Meeting.

Iron deficiency anaemia in early pregnancy increases risk of heart defects, suggests new research

Cardiac Theme Postdoctoral Publication Research

In animal models, iron deficient mothers have a greatly increased risk of having offspring with congenital heart disease (CHD). The risk of CHD can be greatly reduced if the mother is given iron supplements very early in pregnancy. Additionally, embryos from a mouse model of Down Syndrome were particularly vulnerable to the effects of maternal iron deficiency, leading to a higher risk of developing severe heart defects.

New research grant to Pawel Swietach to further understanding of propionic acidemia

Awards and Honours Cardiac Theme

A new collaborative project led by the Swietach group funded by the Propionic Acidemia Foundation will investigate the disease mechanisms and risk factors for cardiac disease caused by a severe inherited disorder.

New MRI technique could detect early signs of heart failure in cancer patients following chemotherapy

Cardiac Theme Postdoctoral Publication Research

New research led by Oxford BHF CRE Intermediate Transition Fellow Dr Kerstin Timm shows that a recently developed imaging technique pioneered by the Tyler Group can detect early metabolic changes in the heart caused by a commonly used chemotherapy drug, which is known to increase risk of heart failure in cancer survivors.

Two major BHF awards to Neil Herring pave the way to new treatments for heart attack patients

Awards and Honours Cardiac Theme Herring Group News

Associate Professor Neil Herring has been awarded a Senior Clinical Research Fellowship and a Project grant from the British Heart Foundation to further critical research into the mechanisms behind heart attacks and heart failure and potential drugs to combat them. Given the 50% reduction in research investment this year from the BHF due to the impact of COVID-19, Prof Herring is to be congratulated on these awards.

MRC Senior Non-Clinical Fellowship awarded to Samira Lakhal-Littleton

Awards and Honours Cardiac Theme EDI News Lakhal-Littleton Group News

Congratulations are in order for Associate Professor Samira Lakhal-Littleton, who has been awarded a Senior Non-Clinical Fellowship by the Medical Research Council to further her lab's work exploring the implications of the cardiac hepcidin/ferroportin axis for the management of iron deficiency in heart failure.

Recharging the battery of the diabetic heart

Cardiac Theme Heather Group News Publication Research

A new paper from the Heather and Tyler groups has uncovered the mechanism responsible for reduced energy in the hearts of patients with type 2 diabetes and revealed a new therapeutic strategy to reverse the energy deficit.

Oliver Neely wins Peter Beaconsfield Prize

Awards and Honours Cardiac Theme EDI News Students

Congratulations are in order for DPhil student Oliver Neely of the Paterson and Domingos labs, who has been awarded the Peter Beaconsfield Prize in Physiological Sciences 2020.

HCQ with antibiotics to treat COVID-19 could be dangerous for the heart

Cardiac Theme Herring Group News Publication Research

DPAG researchers have collaborated on an international study that demonstrates a detailed mechanistic understanding of how the anti-malaria drug, Hydroxychloroquine, combined with antibiotics, can cause adverse cardiac side-effects in COVID-19 patients. This gives weight to US Federal advice against using this combined treatment.

New human heart model set to boost future cardiac research and therapies

Cardiac Theme Postdoctoral Publication Research

DPAG's Dr Jakub Tomek and Professor Blanca Rodriguez's Computational Cardiovascular Science Team have developed a new computer model that recreates the electrical activity of the ventricles in a human heart. In doing so, they have uncovered and resolved theoretical inconsistencies that have been present in almost all models of the heart from the last 25 years and created a new human heart model that could enable more basic, translational and clinical research into a range of heart diseases and potentially accelerate the development of new therapies.

New target identified to help prevent dangerous heart rhythms after heart attack

Cardiac Theme Herring Group News Publication Research

For many years, we have been using beta-blockers to neutralise a specific stress hormone and prevent dangerous heart rhythms following a heart attack. However, a new study led by Associate Professor Neil Herring and published in the European Heart Journal has uncovered evidence for an additional stress hormone acting as a key trigger for dangerous heart rhythms that is not currently targeted by these drugs.

Biomarker predicts which patients with heart failure have a higher risk of dying

Cardiac Theme Herring Group News Publication Research

UCLA Researchers in collaboration with DPAG researchers from the Paterson and Herring Groups have identified a biomarker for increased risk of early mortality in patients with heart failure. Associate Professor Neil Herring is senior author.

Manuela Zaccolo honoured by the Royal Society of Biology

Awards and Honours Cardiac Theme EDI News

Congratulations are in order to Professor Manuela Zaccolo on being elected Fellow of the Royal Society of Biology.

DPAG members shine at the Oxford BHF CRE Annual Symposium 2019

Awards and Honours Cardiac Theme EDI Events Heather Group News Postdoctoral Smart Group News Students

Congratulations are in order to Matthew Kerr, Andia Redpath, Susann Bruche, KC Park and Minahil Mujahid for their achievements at this major showcase for Oxford's British Heart Foundation funded Researchers.

Damian Tyler is an Honorary Skou Professor at the University of Aarhus

Awards and Honours Cardiac Theme

The award recognises and solidifies Professor Tyler's collaborative work with the MR Research Centre, part of the Department of Clinical Medicine at the University of Aarhus.

New approach to reducing damage after a heart attack

Cardiac Theme Herring Group News Publication Research

During the emergency procedure used to reopen the blocked artery causing a heart attack, smaller "micro" blood vessels can remain constricted causing significant damage. A new study led by Associate Professor Neil Herring and published in the European Heart Journal has established a key cause behind this constriction and identified a potential therapeutic target to block the mechanism behind it.

Cardiac, metabolism and cell physiology researchers come together for Integrative Physiology Theme Day

Cardiac Theme EDI Events Head of Department's News Postdoctoral Research Students

The Department's third and final theme day of the year culminated in a series of exciting internal talks from a diverse range of research groups covering all aspects of integrative physiology. From diabetes to iron deficiency, from pH physiology to cancer cells, the talks showcased the huge breadth of science studied across DPAG.

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