8 January 2021
The earliest known progenitor of the outermost layer of the heart has been characterised for the first time and linked to the development of other critical cell types in the developing heart in a new paper from the Srinivas group led by BHF Immediate Fellow Dr Richard Tyser.
New MRI technique could detect early signs of heart failure in cancer patients following chemotherapy
19 November 2020
New research led by Oxford BHF CRE Intermediate Transition Fellow Dr Kerstin Timm shows that a recently developed imaging technique pioneered by the Tyler Group can detect early metabolic changes in the heart caused by a commonly used chemotherapy drug, which is known to increase risk of heart failure in cancer survivors.
12 November 2020
Associate Professor Neil Herring has been awarded a Senior Clinical Research Fellowship and a Project grant from the British Heart Foundation to further critical research into the mechanisms behind heart attacks and heart failure and potential drugs to combat them. Given the 50% reduction in research investment this year from the BHF due to the impact of COVID-19, Prof Herring is to be congratulated on these awards.
27 October 2020
Congratulations are in order for Associate Professor Samira Lakhal-Littleton, who has been awarded a Senior Non-Clinical Fellowship by the Medical Research Council to further her lab's work exploring the implications of the cardiac hepcidin/ferroportin axis for the management of iron deficiency in heart failure.
4 September 2020
A new paper from the Heather and Tyler groups has uncovered the mechanism responsible for reduced energy in the hearts of patients with type 2 diabetes and revealed a new therapeutic strategy to reverse the energy deficit.
11 August 2020
Congratulations are in order to Dr Richard Tyser, who is the 2020 Charles Darwin Award Lecture winner for Agriculture, Biological and Medical Sciences.
26 May 2020
DPAG researchers have collaborated on an international study that demonstrates a detailed mechanistic understanding of how the anti-malaria drug, Hydroxychloroquine, combined with antibiotics, can cause adverse cardiac side-effects in COVID-19 patients. This gives weight to US Federal advice against using this combined treatment.
27 April 2020
New collaborative research from the Mommersteeg Group and MRC WIMM researchers shows that a protein called Runx1 plays a significant role in the formation of the cardiac scar that forms after the heart is injured, a scar that is known to inhibit heart regeneration. In the zebrafish, a freshwater fish known to be able to fully regenerate its heart after damage, they show that the absence of Runx1 results in enhanced regeneration. This indicates a potential new therapeutic target for heart repair.
31 January 2020
DPAG's Dr Jakub Tomek and Professor Blanca Rodriguez's Computational Cardiovascular Science Team have developed a new computer model that recreates the electrical activity of the ventricles in a human heart. In doing so, they have uncovered and resolved theoretical inconsistencies that have been present in almost all models of the heart from the last 25 years and created a new human heart model that could enable more basic, translational and clinical research into a range of heart diseases and potentially accelerate the development of new therapies.
30 January 2020
An immune cell is shown for the first time to be involved in creating the scar that repairs the heart after damage. The Riley Group study was funded by the British Heart Foundation and led by BHF CRE Intermediate Transition Research Fellow Dr Filipa Simões.
8 January 2020
For many years, we have been using beta-blockers to neutralise a specific stress hormone and prevent dangerous heart rhythms following a heart attack. However, a new study led by Associate Professor Neil Herring and published in the European Heart Journal has uncovered evidence for an additional stress hormone acting as a key trigger for dangerous heart rhythms that is not currently targeted by these drugs.
7 January 2020
UCLA Researchers in collaboration with DPAG researchers from the Paterson and Herring Groups have identified a biomarker for increased risk of early mortality in patients with heart failure. Associate Professor Neil Herring is senior author.
21 October 2019
Congratulations are in order to Professor Manuela Zaccolo on being elected Fellow of the Royal Society of Biology.
17 October 2019
Congratulations are in order to Matthew Kerr, Andia Redpath, Susann Bruche, KC Park and Minahil Mujahid for their achievements at this major showcase for Oxford's British Heart Foundation funded Researchers.
15 October 2019
The award recognises and solidifies Professor Tyler's collaborative work with the MR Research Centre, part of the Department of Clinical Medicine at the University of Aarhus.
14 August 2019
This year's "Reflections of Research" competition, run by the British Heart Foundation, selects "The Forming Heart" by Dr Richard Tyser as the Judge's runner-up
22 July 2019
A collaborative paper from the De Val and Smart Groups has established multiple regulatory pathways responsible for the formation of blood vessels in the developing heart. In doing so they have identified a crucial pathway that is repressed in the adult heart after injury, which may hold the key to a new and improved strategy for repair.
12 July 2019
During the emergency procedure used to reopen the blocked artery causing a heart attack, smaller "micro" blood vessels can remain constricted causing significant damage. A new study led by Associate Professor Neil Herring and published in the European Heart Journal has established a key cause behind this constriction and identified a potential therapeutic target to block the mechanism behind it.
Sarah De Val set to expand critical research into endothelial cell dysfunction in cardiovascular disease
12 July 2019
Prof Sarah De Val in collaboration with Dr Gillian Douglas from the Radcliffe Department of Medicine has received a grant from the John Fell Fund to support their work investigating the behaviour of different endothelial regulatory pathways during disorders of the cardiovascular system.