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- Molnar Group Research Group
DPhil, MSc, BSc
Postdoctoral Research Scientist
I am a post-doc in the Molnár laboratory and focus my research on the subplate, a partially transient structure separating the cortical grey matter from the underlying white matter. However, the clarity of the worm neuronal wiring diagram still fascinates me, and I am working towards identifying the neuronal components that comprise the mouse subplate layer. We have used microarrays and RNAseq technology to identify genes that are expressed exclusively or at much higher levels in the mouse subplate. We test the general usefulness of our “markers” in diverse species including embryonic human brain tissue (from Newcastle and London brain banks), ferret, and sheep. Additionally, we’ve demonstrated that genes with enriched expression in the subplate are significantly enriched for genes implicated in Autism or Schizophrenia, compared to other brain expressed genes.
Although originally from Germany, I read for a degree in Combined Sciences (Physiology, Genetics and Physics) at the University of Lancaster, UK. I spent a year studying in the US at UC San Diego and a summer as Howard Hughes Undergraduate Research Fellow at the University of Pittsburgh in Prof Steve Meriney’s lab investigating calcium signalling at the frog neuromuscular junction in 2001. I then moved to Oxford for my MSc in Neuroscience in 2002, during which I worked primarily with the nematode worm (C. elegans), before settling on the developing mammalian cerebral cortex as my choice of research topic. I completed my DPhil (PhD) as a Wellcome Trust funded Biological Sciences Scholar at St Hugh’s College (Oxford), under the joint supervision of Profs Ole Paulsen and Zoltán Molnár in 2007. Since 2007, I’ve been working at the University of Oxford as a postdoc, with the aim of identifying the neuronal components of the mouse subplate and finding molecular markers for them.
A missense mutation in Katnal1 underlies behavioural, neurological and ciliary anomalies.
Banks G. et al, (2018), Mol Psychiatry, 23, 713 - 722
Subset of Cortical Layer 6b Neurons Selectively Innervates Higher Order Thalamic Nuclei in Mice.
Hoerder-Suabedissen A. et al, (2018), Cereb Cortex
Transient Hypoxemia Chronically Disrupts Maturation of Preterm Fetal Ovine Subplate Neuron Arborization and Activity.
McClendon E. et al, (2017), J Neurosci, 37, 11912 - 11929
Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges.
Millar LJ. et al, (2017), Front Cell Neurosci, 11
Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling.
Cheng J. et al, (2016), Neuron, 92, 126 - 142