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Epigenetic regulation of adult neurogenesis

Epigenetic regulation of adult neurogenesis

SVZ stem cells

SVZ stem cells

Ventral emigration

Ventral emigration

Explant migration

Explant migration
Research Summary

LAB NEWS:

New Members:

Anna Gerhartl, Undergraduate Student from Austria, August, 2013 - January, 2014.

Ulrich Bauer, Masters Student Biochem Oxofrd, October 2013 - April, 2014.

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Francis Szele


Associate Professor of Developmental Biology

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Biography

The main goals of my lab are to understand fundamental mechanisms governing stem cell behaviours and progenitor migration in the postnatal and adult neurogenic subventricular zone system in mouse. We also seek to understand how these mechanisms are altered in response to disease models and how to exogenously manipulate them to enhance repair. Finally we are studying the human subventricular zone in healthy controls and in neuropsychiatric diseases.


I graduated from the College of William and Mary in the USA with a major in Biology. I then worked for two years in the laboratory of Dennis Murphy at the National Institute of Mental Health (Bethesda, Maryland, 1985-1987) on serotonergic control of endocrine responses. I obtained my PhD (1994) working in the laboratory of Marie-Francoise Chesselet at the University of Pennsylvania (Philadelphia, USA) where I carried out one of the first studies showing increased neurogenesis after brain injury. I subsequently did a postdoctoral fellowship in Connie Cepko’s laboratory (Harvard Medical School, Boston, USA, 1994-1999). There I used a complex library of retroviral vectors to examine lineage relationships and migration patterns in the developing chick forebrain. I established my laboratory in Chicago at Northwestern University’s Childrens Memorial Research Center returning to work on the subventricular zone (Assistant Professor, 1999-2007). In collaboration with Phil Hockberger (Northwestern University) my group developed 2-photon time-lapse imaging to study cell migration in the subventricular zone. From 2001-2002 I was a Searle Junior Fellow at the Searle Center for Teaching Excellence, Northwestern University and also held the Bernard L. Mirkin Research Scholar Endowed Chair from 2005-2007.


I was appointed to a University Lecturer position at the Department of Physiology, Anatomy and Genetics associated with a Tutorial Fellowship at St Anne's College, Oxford in 2007.

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Key Publications

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Recent Publications

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Differentiated Neurosphere

Differentiated Neurosphere

Neurospheres

Neurospheres