|Tel||01865 274888, 01865 282627|
Epigenetic regulation of adult neurogenesis
Associate Professor of Developmental Biology
The main goals of my lab are to understand fundamental mechanisms governing stem cell behaviours and progenitor migration in the postnatal and adult neurogenic subventricular zone system in mouse. We also seek to understand how these mechanisms are altered in response to disease models and how to exogenously manipulate them to enhance repair. Finally we are studying the human subventricular zone in healthy controls and in neuropsychiatric diseases.
I graduated from the College of William and Mary in the USA with a major in Biology. I then worked for two years in the laboratory of Dennis Murphy at the National Institute of Mental Health (Bethesda, Maryland, 1985-1987) on serotonergic control of endocrine responses. I obtained my PhD (1994) working in the laboratory of Marie-Francoise Chesselet at the University of Pennsylvania (Philadelphia, USA) where I carried out one of the first studies showing increased neurogenesis after brain injury. I subsequently did a postdoctoral fellowship in Connie Cepko’s laboratory (Harvard Medical School, Boston, USA, 1994-1999). There I used a complex library of retroviral vectors to examine lineage relationships and migration patterns in the developing chick forebrain. I established my laboratory in Chicago at Northwestern University’s Childrens Memorial Research Center returning to work on the subventricular zone (Assistant Professor, 1999-2007). In collaboration with Phil Hockberger (Northwestern University) my group developed 2-photon time-lapse imaging to study cell migration in the subventricular zone. From 2001-2002 I was a Searle Junior Fellow at the Searle Center for Teaching Excellence, Northwestern University and also held the Bernard L. Mirkin Research Scholar Endowed Chair from 2005-2007.
I was appointed to a University Lecturer position at the Department of Physiology, Anatomy and Genetics associated with a Tutorial Fellowship at St Anne's College, Oxford in 2007.
Ependymal ciliary dysfunction and reactive astrocytosis in a reorganized subventricular zone after stroke.
Young CC. et al, (2013), Cereb Cortex, 23, 647 - 659
Galectin-3 maintains cell motility from the subventricular zone to the olfactory bulb.
Comte I. et al, (2011), J Cell Sci, 124, 2438 - 2447
Dynamic features of postnatal subventricular zone cell motility: a two-photon time-lapse study.
Nam SC. et al, (2007), J Comp Neurol, 505, 190 - 208
Cortical lesions induce an increase in cell number and PSA-NCAM expression in the subventricular zone of adult rats.
Szele FG. and Chesselet MF., (1996), J Comp Neurol, 368, 439 - 454
Expression of Idh1(R132H) in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis.
Bardella C. et al, (2016), Cancer Cell, 30, 578 - 594
Loss of galectin-3 decreases the number of immune cells in the subventricular zone and restores proliferation in a viral model of multiple sclerosis.
James RE. et al, (2016), Glia, 64, 105 - 121
Gradient Index Microlens Implanted in Prefrontal Cortex of Mouse Does Not Affect Behavioral Test Performance over Time.
Lee SA. et al, (2016), PLoS One, 11
Disruption of Visc-2, a Brain-Expressed Conserved Long Noncoding RNA, Does Not Elicit an Overt Anatomical or Behavioral Phenotype.
Oliver PL. et al, (2015), Cereb Cortex, 25, 3572 - 3585
STAT1-induced ASPP2 transcription identifies a link between neuroinflammation, cell polarity, and tumor suppression.
Turnquist C. et al, (2014), Proc Natl Acad Sci U S A, 111, 9834 - 9839