A role for the cortex in sleep-wake regulation.

Krone LB., Yamagata T., Blanco-Duque C., Guillaumin MCC., Kahn MC., van der Vinne V., McKillop LE., Tam SKE., Peirson SN., Akerman CJ., Hoerder-Suabedissen A., Molnár Z., Vyazovskiy VV.

Cortical and subcortical circuitry are thought to play distinct roles in the generation of sleep oscillations and global state control, respectively. Here we silenced a subset of neocortical layer 5 pyramidal and archicortical dentate gyrus granule cells in male mice by ablating SNAP25. This markedly increased wakefulness and reduced rebound of electroencephalographic slow-wave activity after sleep deprivation, suggesting a role for the cortex in both vigilance state control and sleep homeostasis.

DOI

10.1038/s41593-021-00894-6

Type

Journal article

Journal

Nat Neurosci

Publication Date

09/2021

Volume

24

Pages

1210 - 1215

Keywords

Animals, Dentate Gyrus, Male, Mice, Mice, Transgenic, Neocortex, Neurons, Sleep, Synaptosomal-Associated Protein 25, Wakefulness

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