Gene Transfer
Exercise training enhances NOS-1 (neuronal isoform) expression in sympathetic (1) and parasympathetic intra cardiac ganglia (2). Physical training also accelerates vagally mediated recovery of heart rate following exertion (3) and increases in vagal tone (4). These effects are believed to result from reduced sympathetic (1) and increased parasympathetic control (2) of heart rate, and are likely due to enhanced NO bioavailability. We are using adenovirus-mediated NOS-1 gene transfer into right atrial tissue to mimic these effects and investigate this hypothesis.
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