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Marissa Mueller

Postdoctoral Scientist in Preclinical Neuroimaging

Current Role

I am a postdoctoral research scientist with experience in neurodevelopmental biology, histology, bioengineering, behavioural studies, and preclinical neuroimaging. I am part of a team led by Prof. Jason Lerch in the Nuffield Department of Clinical Neurosciences which aims to sensitise MRI to specific cell subtypes, densities, and morphologies in the brain. This work is supported by a Wellcome Bioimaging Technology Development Award.

Research Focus

  • Characterising mouse models featuring genetically-abolished presynaptic vesicle release and regulated neurotransmission in subpopulations of cortical layer 5-6 projection neurons
  • Developing and validating preclinical MRI methods
  • Analysing multimodal datasets to gain complimentary insight into the roles of cell subtypes and associated networks

Background

I completed my DPhil in Physiology, Anatomy, and Genetics at the University of Oxford where I studied the role of deep-layer corticofugal neurons in progressive neuroanatomical and motor degeneration. Prior to this, I completed my MSc in Neuroscience (University of Oxford) and BSc in Engineering (University of Iowa) with a specialisation in stem cells and regenerative biology. I am originally from Petrolia, Ontario, Canada.

Neuroimaging and histology

This image of a mouse brain was obtained using spinning disk confocal microscopy. Our team merges histological, neuroimaging, and behavioural techniques to characterise the effects of genetic manipulations to cell subpopulations indicated as conceivable substrates for developmental origins of neuropathologies, including but not limited to motor neuron disease. © Produced in collaboration with Dr. Florina Szabo, Oxford’s Cellular Imaging Core (CHG), and the Eikholt Group (Charité University)
This image of a mouse brain was obtained using spinning disk confocal microscopy. Our team merges histological, neuroimaging, and behavioural techniques to characterise the effects of genetic manipulations to cell subpopulations indicated as conceivable substrates for developmental origins of neuropathologies, including but not limited to motor neuron disease.

Collaborators