- Wade-Martins Group Research Group
Postdoctoral Research Scientist
My research focusses on alpha-synuclein aggregation during the progression of Parkinson’s disease. Even though it is known that alpha-synuclein aggregation is a key feature of Parkinson’s disease progression there are still many unanswered questions. Where does the toxic aggregation begin? How does it spread? How can we prevent these processes? In order to study the aggregation process and answer these questions we benefit from access to genetic models, patient-derived induced pluripotent stem (iPS) cells, human tissue and alpha-synuclein PLA-based assays, which will help us provide novel insights of the role alpha-synuclein oligomers play in the disease and so, could be used to identify new treatments for Parkinson’s disease.
In March 2015 I joined the Wade-Martins laboratory and have since worked on the role of alpha-synuclein aggregation in Parkinson’s disease. After graduating I started and Masters in Molecular Biology and Biomedicine, in which I studied the differentiation of human embryonic carcinoma stem cells. This led me to develop an interest in the use of stem cells as models for human neuronal differentiation. In 2014 I completed a PhD at the University of the Basque Country which focused on the study of the role of Wnt signaling during early neuronal differentiation in human stem cell models.
Identification of Noncanonical Wnt Receptors Required for Wnt-3a-Induced Early Differentiation of Human Neural Stem Cells
Bengoa-Vergniory N. et al, (2016), Molecular Neurobiology
The stem cell cocktail: neural reprogramming just got easier.
Bengoa-Vergniory N. and Kypta R., (2016), Stem Cell Investig, 3
Dickkopf-3 regulates prostate epithelial cell acinar morphogenesis and prostate cancer cell invasion by limiting TGF-β-dependent activation of matrix metalloproteases.
Romero D. et al, (2016), Carcinogenesis, 37, 18 - 29
Canonical and noncanonical Wnt signaling in neural stem/progenitor cells.
Bengoa-Vergniory N. and Kypta RM., (2015), Cell Mol Life Sci, 72, 4157 - 4172
A switch from canonical to noncanonical Wnt signaling mediates early differentiation of human neural stem cells.
Bengoa-Vergniory N. et al, (2014), Stem Cells, 32, 3196 - 3208