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Publications

REST Protects Dopaminergic Neurons from Mitochondrial and α-Synuclein Oligomer Pathology in an Alpha Synuclein Overexpressing BAC-Transgenic Mouse Model.

Ryan BJ. et al, (2021), J Neurosci, 41, 3731 - 3746

Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer's disease.

Bengoa-Vergniory N. et al, (2021), Acta Neuropathol Commun, 9

GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model.

Roberts BM. et al, (2020), Nat Commun, 11

CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease.

Bengoa-Vergniory N. et al, (2020), Nat Commun, 11

Transgenic Mice Expressing Human α-Synuclein in Noradrenergic Neurons Develop Locus Ceruleus Pathology and Nonmotor Features of Parkinson's Disease.

Butkovich LM. et al, (2020), J Neurosci, 40, 7559 - 7576

Understanding the pathophysiological role of early tau aggregates in Alzheimer's disease by their direct visualisation in situ

Velentza-Almpani E. et al, (2020), NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 46, 42 - 42

Selective vulnerability in α-synucleinopathies.

Alegre-Abarrategui J. et al, (2019), Acta Neuropathol, 138, 681 - 704

Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior.

Hunn BHM. et al, (2019), Cell Rep, 29, 920 - 931.e7

Astrocytic striatal GABA transporter activity governs dopamine release and shows maladaptive downregulation in early parkinsonism

Roberts BM. et al, (2019)

Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons.

Zambon F. et al, (2019), Hum Mol Genet, 28, 2001 - 2013

Alpha-Synuclein Proximity Ligation Assay (AS-PLA) in Brain Sections to Probe for Alpha-Synuclein Oligomers.

Roberts RF. et al, (2019), Methods Mol Biol, 1948, 69 - 76

Targeting Alpha-Synuclein as a Therapy for Parkinson's Disease.

Fields CR. et al, (2019), Front Mol Neurosci, 12

Detection of alpha-synuclein conformational variants from gastro-intestinal biopsy tissue as a potential biomarker for Parkinson's disease.

Ruffmann C. et al, (2018), Neuropathol Appl Neurobiol, 44, 722 - 736

Alpha-synuclein oligomers: a new hope.

Bengoa-Vergniory N. et al, (2017), Acta Neuropathol, 134, 819 - 838

Loss of MicroRNA-7 Regulation Leads to α-Synuclein Accumulation and Dopaminergic Neuronal Loss In Vivo.

McMillan KJ. et al, (2017), Mol Ther, 25, 2404 - 2414

Increased 4R tau expression and behavioural changes in a novel MAPT-N296H genomic mouse model of tauopathy.

Wobst HJ. et al, (2017), Sci Rep, 7

Preclinical development of a vaccine against oligomeric alpha-synuclein based on virus-like particles.

Doucet M. et al, (2017), PLoS One, 12

Identification of Noncanonical Wnt Receptors Required for Wnt-3a-Induced Early Differentiation of Human Neural Stem Cells

Bengoa-Vergniory N. et al, (2016), Molecular Neurobiology

Colonic alpha-synuclein: A potential diagnostic biomarker in Parkinson's disease

Ruffmann C. et al, (2016), MOVEMENT DISORDERS, 31, S584 - S584

Dickkopf-3 regulates prostate epithelial cell acinar morphogenesis and prostate cancer cell invasion by limiting TGF-β-dependent activation of matrix metalloproteases.

Romero D. et al, (2016), Carcinogenesis, 37, 18 - 29

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