Dr Kerstin Nina Timm
Visiting BHF Immediate Postdoctoral Basic Science Research Fellow
- Fulford Junior Research Fellow Somerville College
- Postdoctoral Research Scientist
My main research focus is the application of an imaging technique called hyperpolarized magnetic resonance to different models of human disease.
After my undergraduate in veterinary medicine in Berlin, Germany I went to the University of Cambridge to undertake my MRes and PhD in Prof Kevin Brindle’s laboratory. Here I studied metabolic fluxes in different models of cancer using hyperpolarized MRI. I completed my PhD in 2016 and subsequently secured a British Heart Foundation Immediate Postdoctoral Basic Science Research Fellowship to work with Prof Damian Tyler here at DPAG in Oxford.
I am now focusing on the metabolic effects of the chemotherapeutic doxorubicin on the heart. Specifically, I am using hyperpolarized MRI to study metabolic fluxes in a model of doxorubicin-induced cardiotoxicity. I am collaborating with Dr Julian Griffin at the University of Cambridge, where I analyse metabolomic and lipidomic effects of doxorubicin on the heart. I am hoping to unravel early changes to metabolism in the heart that precede functional decline, which would open up a window of opportunity for adjuvant treatment in cancer patients receiving doxorubicin. This could ultimately improve cardiac outcomes in cancer survivors.
The Role of AMPK Activation for Cardioprotection in Doxorubicin-Induced Cardiotoxicity.
Timm KN. and Tyler DJ., (2020), Cardiovasc Drugs Ther
Assessing the optimal preparation strategy to minimize the variability of cardiac pyruvate dehydrogenase flux measurements with hyperpolarized MRS.
Timm KN. et al, (2018), NMR Biomed, 31
Fatty Acids Prevent Hypoxia-Inducible Factor-1α Signaling Through Decreased Succinate in Diabetes.
Dodd MS. et al, (2018), JACC Basic Transl Sci, 3, 485 - 498
Cardiac applications of hyperpolarised magnetic resonance.
Timm KN. et al, (2018), Prog Nucl Magn Reson Spectrosc, 106-107, 66 - 87
DEPLETION OF CARDIAC SUCCINATE MEDIATES IMPAIRED HYPOXIA-INDUCIBLE FACTOR 1A SIGNALLING BY LONG CHAIN FATTY ACIDS IN INSULIN RESISTANCE
Dodd MS. et al, (2018), HEART, 104, A11 - A11