Dr Kerstin Nina Timm
Visiting BHF Immediate Postdoctoral Basic Science Research Fellow
- Fulford Junior Research Fellow Somerville College
- Postdoctoral Research Scientist
My main research focus is the application of an imaging technique called hyperpolarized magnetic resonance to different models of human disease.
After my undergraduate in veterinary medicine in Berlin, Germany I went to the University of Cambridge to undertake my MRes and PhD in Prof Kevin Brindle’s laboratory. Here I studied metabolic fluxes in different models of cancer using hyperpolarized MRI. I completed my PhD in 2016 and subsequently secured a British Heart Foundation Immediate Postdoctoral Basic Science Research Fellowship to work with Prof Damian Tyler here at DPAG in Oxford.
I am now focusing on the metabolic effects of the chemotherapeutic doxorubicin on the heart. Specifically, I am using hyperpolarized MRI to study metabolic fluxes in a model of doxorubicin-induced cardiotoxicity. I am collaborating with Dr Julian Griffin at the University of Cambridge, where I analyse metabolomic and lipidomic effects of doxorubicin on the heart. I am hoping to unravel early changes to metabolism in the heart that precede functional decline, which would open up a window of opportunity for adjuvant treatment in cancer patients receiving doxorubicin. This could ultimately improve cardiac outcomes in cancer survivors.
Nicotinic acid receptor agonists impair myocardial contractility by energy starvation.
Watson WD. et al, (2020), FASEB J
Probing hepatic metabolism of [2-13C]dihydroxyacetone in vivo with 1H-decoupled hyperpolarized 13C-MR.
Marco-Rius I. et al, (2020), MAGMA
A 3D hybrid-shot spiral sequence for hyperpolarized
Tyler A. et al, (2020), Magn Reson Med
A 3D hybrid-shot spiral sequence for hyperpolarized 13C imaging
TYLER D. et al, (2020), Magnetic Resonance in Medicine
Rescue of myocardial energetic dysfunction in diabetes through the correction of mitochondrial hyperacetylation by honokiol.
Kerr M. et al, (2020), JCI Insight, 5