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Professor Samira Lakhal-Littleton

In the past decade, the Lakhal-Littleton team have uncovered the mechanisms and importance of iron regulation in different cells within the cardiovascular system 1-5 . More recently, their discoveries have challenged accepted notions about how the heart handles iron from intravenous iron therapy in patients 6. The current review harnesses this growing understanding to dissect, at a more mechanistic level, the adverse impact of iron deficiency in heart failure patients, and the mixed success of iron supplementation therapies in this context7. It also highlights untapped opportunities for improving the management of iron deficiency in heart failure.

  1. DOI: 10.1161/ATVBAHA.123.319224
  2. DOI: 10.3389/fcvm.2020.616920
  3. DOI: 10.1073/pnas.1822010116
  4. DOI: 10.1073/pnas.1422373112
  5. DOI: 10.7554/eLife.19804
  7. DOI: 10.1038/s41569-024-00988-1  (fulltext available on

Read more about the research being done by the Lakhal-Littleton group here

Read the full article at