Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we will assume that you are happy to receive all cookies and you will not see this message again. Click 'Find out more' for information on how to change your cookie settings.

Dame Kay Davies, Dr Lee’s Professor of Anatomy here in DPAG, has been working on a clinical trial that today announced a potentially life-changing discovery.

Summit Therapeutics, the drug discovery and development company advancing therapies for rare diseases and infectious diseases, for which Professor Davies is a co-founder, have released the interim results from the trial, PhaseOut DMD, which had been evaluating the effect of ezutromid in patients with Duchenne muscular dystrophy, DMD.

Discoveries show that ezutromid does indeed reduce muscle damage significantly in DMD patients; a total of 14 out of 22 patients showed a decrease in developmental myosin, a biomarker of muscle damage, with five of those patients showing a greater than 40% reduction.

DMD is a progressive muscle wasting disease that affects around 50,000 boys and young men in the developed world. The results from the trial suggest a potential universal treatment for DMD, since there is currently no cure for DMD and life expectancy is into the late twenties.

Professor Davies is delighted at the results from the trial, saying: These data provide the first evidence of utrophin modulation working in patients. If further findings build on this evidence they could establish ezutromid as a universal, disease-modifying treatment and bring hope to all patients and families living with DMD.

Similar stories

Thomas Willis (1621 - 1675) 400th Birthday - Alastair Compston in conversation with Zoltán Molnár: An insight into the writings of Willis

General Research

Professor Zoltán Molnár talks to Professor Emeritus of Neurology Alastair Compston FRS about the deeply influential texts written by the Founder of Neurology Thomas Willis four centuries ago.

New form of gift wrap drives male reproductive success

Publication Research Wilson Group News

The transfer of complex mixtures of signals and nutrients between individuals is a key step in several biologically important events in our lives, such as breastfeeding and sexual intercourse. However, we know relatively little about the ways in which the molecular gifts involved are packaged to ensure their successful delivery to the recipient.

Thomas Willis (1621 - 1675) 400th Birthday - Chrystalina Antoniades in conversation with Zoltán Molnár: The Circle of Willis

General Research

Professor Zoltán Molnár talks to Associate Professor Chrystalina Antoniades for an in-depth look at the Circle of Willis, the name given to the arterial ring at the base of the brain, in recognition of the man renowned for its original description.

Just over half of British Indians would take COVID vaccine

EDI News Outreach Postdoctoral Publication Research Riley Group News

University of Oxford researchers from the Department of Physiology, Anatomy and Genetics (DPAG) and the Department of Psychiatry, in collaboration with The 1928 Institute, have published a major new study on the impact of COVID-19 on the UK’s largest BME population.

Thomas Willis (1621 - 1675) 400th Birthday - Alastair Buchan in conversation with Zoltán Molnár

General Research

Professor Zoltán Molnár talks to Pro-Vice-Chancellor Professor Alastair Buchan to learn more about Thomas Willis's residence and base for scientific discoveries, Beam Hall.

Thomas Willis (1621 - 1675) 400th Birthday - Erica Charters in conversation with Zoltán Molnár

General Research

Professor Zoltán Molnár talks to Dr Erica Charters for a History of Medicine perspective on Oxford physician and Father of Neurology Thomas Willis.