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A single isolated human induced pluripotent stem cell-derived cortical neuron grows over five days labelled with green fluorescent protein under a high-content imager. Scale bar = 100 micrometer.

Bryan Ng, a scientist now based at the Agency for Science, Technology and Research (A*STAR) in Singapore, has written a blog post about a paper recently published in Molecular Psychiatry written with Oxford colleagues on his DPhil project conducted in the Wade-Martins Group here at DPAG.

The blog post gives a short overview of the research, explaining how the Oxford team of researchers used CRISPR-Cas9-mediated gene manipulation to cause chronic tau depletion in human induced pluripotent stem cells (iPSCs). These iPSCs were then turned into cortical neurons in a dish to study their responses to toxic amyloid-beta (Abeta) treatments. Modelling Alzheimer’s disease with human neurons revealed how amyloid cannot exert its toxicity without tau.

 You can read the blog post here

The original paper to which it refers is published here