- Srinivas Group Research Group
PhD MRes BSc (Exon)
Postdoctoral Research Scientist
Matthew Stower is a PostDoctoral Researcher in Prof. Shankar Srinivas' group at Oxford University. His work in the lab involves developing live imaging strategies to investigate epithelial tissue morphogenesis and understand fundamental cellular processes including the cellular mechanisms controlling cell migration in epithelia, the regulation cytoskeletal-elements, and the mechanisms controlling cell polarity and cell fate.
Matthew read Biological Sciences (BSc, First Class Hons) at the University of Exeter, where he first discovered his interest in developmental biology. He was able to pursue this interest at Post Graduate level through a BBSRC scholarship for the MRes, Regenerative Medicine course at the University of Bath where he worked on neural crest migration in the lab of Prof. Robert Kelsh. For his PhD research project he moved to University College London to investigate the earliest molecular events controlling the induction of the nervous system under the supervision of Prof. Claudio Stern FRS.
During his time at Oxford, Matthew has been involved with running the DPAG PostDoc Research Society (committee member 2013-2017 & president 2015-2016), he has also supervised the laboratory research of students on both FHS and MSc Clinical Sciences courses, tutored undergraduate medics (New College Oxford), and has also collaborated on research projects with Dr Federica Bertocchini (Evo-Devo project on Amniote gastrulation) at the University of Cantabria, and Dr Isabelle Migeotte (live imaging of gastrulation stage embryos) at Universitie Libre de Bruxelles.
Neural induction by the node and placode induction by head mesoderm share an initial state resembling neural plate border and ES cells.
Trevers KE. et al, (2018), Proc Natl Acad Sci U S A, 115, 355 - 360
Bi-modal strategy of gastrulation in reptiles.
Stower MJ. et al, (2015), Dev Dyn
Heading forwards: anterior visceral endoderm migration in patterning the mouse embryo.
Stower MJ. and Srinivas S., (2014), Philos Trans R Soc Lond B Biol Sci, 369
Distinct steps of neural induction revealed by Asterix, Obelix and TrkC, genes induced by different signals from the organizer.
Pinho S. et al, (2011), PLoS One, 6
Cell communication with the neural plate is required for induction of neural markers by BMP inhibition: evidence for homeogenetic induction and implications for Xenopus animal cap and chick explant assays
Linker C. et al, (2009), Developmental Biology, 327, 478 - 486
The evolution of amniote gastrulation: the blastopore-primitive streak transition.
Stower MJ. and Bertocchini F., Wiley Interdiscip Rev Dev Biol, 6