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- Buckler Group Research Group
Associate Professor of Physiology
Keith Buckler studied for his first degree in Biochemistry at Kings College London and subsequently for a PhD in 1988 from the Faculty of Medicine, University of Newcastle upon Tyne. He subsequently came to Oxford as a postdoctoral research assistant in the laboratory of Prof R.D. Vaughan-Jones in 1989 before being awarded an MRC Senior Research Fellowship in 1993. He was a Junior Research Fellow of Queens College from 1993 - 1998. In 2001 he was appointed to a Tutorial Fellowship at Trinity College. In 2003 he took up a University Lectureship in the Department of Physiology.
Keith Buckler’s research interests are in the areas of peripheral chemoreception and the effects of hypoxia, acidosis & ischemia on neuronal function. Peripheral chemoreceptors are specialised oxygen and acid sensors that play a vital role in controlling both ventilation and the cardiovascular system. His research in this area is focused primarily upon trying to elucidate the primary cellular mechanisms of sensory transduction for both oxygen and acid. He is also currently engaged in research into the effects of chronic hypoxia on chemoreceptor function and the effects of general anaesthetics. Keith Buckler also has interests in the effects of hypoxia, acidosis and ischemia on peripheral neuron function, particularly calcium signalling. (see the Buckler research group page for further information).
Oxygen sensitivity of mitochondrial function in rat arterial chemoreceptor cells.
Buckler KJ. and Turner PJ., (2013), J Physiol, 591, 3549 - 3563
Effects of exogenous hydrogen sulphide on calcium signalling, background (TASK) K channel activity and mitochondrial function in chemoreceptor cells.
Buckler KJ., (2012), Pflugers Arch, 463, 743 - 754
The effect of mitochondrial inhibitors on membrane currents in isolated neonatal rat carotid body type I cells.
Wyatt CN. and Buckler KJ., (2004), J Physiol, 556, 175 - 191
An oxygen-, acid- and anaesthetic-sensitive TASK-like background potassium channel in rat arterial chemoreceptor cells.
Buckler KJ. et al, (2000), J Physiol, 525 Pt 1, 135 - 142
A novel oxygen-sensitive potassium current in rat carotid body type I cells.
Buckler KJ., (1997), J Physiol, 498 ( Pt 3), 649 - 662
A method for continuous and stable perfusion of tissue and single cell preparations with accurate concentrations of volatile anaesthetics.
Huskens N. et al, (2016), J Neurosci Methods, 258, 87 - 93
Moderate inhibition of mitochondrial function augments carotid body hypoxic sensitivity.
Holmes AP. et al, (2016), Pflugers Arch, 468, 143 - 155
TASK channels in arterial chemoreceptors and their role in oxygen and acid sensing.
Buckler KJ., (2015), Pflugers Arch, 467, 1013 - 1025
TASK channels in arterial chemoreceptors and their role in oxygen and acid sensing
Buckler KJ., (2015), Pflugers Archiv European Journal of Physiology, 467, 1013 - 1025
Functional Properties of Mitochondria in the Type-1 Cell and Their Role in Oxygen Sensing.
Buckler KJ. and Turner PJ., (2015), 860, 69 - 80