Research groups
Colleges
Research groups
Keith Buckler
Associate Professor of Physiology
Keith Buckler studied for his first degree in Biochemistry at Kings College London and subsequently for a PhD in 1988 from the Faculty of Medicine, University of Newcastle upon Tyne. He subsequently came to Oxford as a postdoctoral research assistant in the laboratory of Prof R.D. Vaughan-Jones in 1989 before being awarded an MRC Senior Research Fellowship in 1993. He was a Junior Research Fellow of Queens College from 1993 - 1998. In 2001 he was appointed to a Tutorial Fellowship at Trinity College. In 2003 he took up a University Lectureship in the Department of Physiology.
Keith Buckler’s research interests are in the areas of peripheral chemoreception and the effects of hypoxia, acidosis & ischemia on neuronal function. Peripheral chemoreceptors are specialised oxygen and acid sensors that play a vital role in controlling both ventilation and the cardiovascular system. His research in this area is focused primarily upon trying to elucidate the primary cellular mechanisms of sensory transduction for both oxygen and acid. He is also currently engaged in research into the effects of chronic hypoxia on chemoreceptor function and the effects of general anaesthetics. Keith Buckler also has interests in the effects of hypoxia, acidosis and ischemia on peripheral neuron function, particularly calcium signalling. (see the Buckler research group page for further information).
Key publications
-
Oxygen sensitivity of mitochondrial function in rat arterial chemoreceptor cells.
Journal article
Buckler KJ. and Turner PJ., (2013), J Physiol, 591, 3549 - 3563
-
Effects of exogenous hydrogen sulphide on calcium signalling, background (TASK) K channel activity and mitochondrial function in chemoreceptor cells.
Journal article
Buckler KJ., (2012), Pflugers Arch, 463, 743 - 754
-
The effect of mitochondrial inhibitors on membrane currents in isolated neonatal rat carotid body type I cells.
Journal article
Wyatt CN. and Buckler KJ., (2004), J Physiol, 556, 175 - 191
-
An oxygen-, acid- and anaesthetic-sensitive TASK-like background potassium channel in rat arterial chemoreceptor cells.
Journal article
Buckler KJ. et al, (2000), J Physiol, 525 Pt 1, 135 - 142
-
A novel oxygen-sensitive potassium current in rat carotid body type I cells.
Journal article
Buckler KJ., (1997), J Physiol, 498 ( Pt 3), 649 - 662
Recent publications
-
Hif-2α programmes oxygen chemosensitivity in chromaffin cells.
Journal article
Prange-Barczynska M. et al, (2024), J Clin Invest
-
Competitive Interactions between Halothane and Isoflurane at the Carotid Body and TASK Channels.
Journal article
Pandit JJ. et al, (2020), Anesthesiology, 133, 1046 - 1059
-
Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control.
Journal article
Cheng X. et al, (2020), J Clin Invest, 130, 2237 - 2251
-
Influence of propofol on isolated neonatal rat carotid body glomus cell response to hypoxia and hypercapnia.
Journal article
O'Donohoe PB. et al, (2019), Respir Physiol Neurobiol, 260, 17 - 27
-
A1899, PK-THPP, ML365, and Doxapram inhibit endogenous TASK channels and excite calcium signaling in carotid body type-1 cells.
Journal article
O'Donohoe PB. et al, (2018), Physiol Rep, 6