David Paterson

• Impaired cAMP-cGMP cross-talk during cardiac sympathetic dysautonomia.

  Bardsley EN. et al, (2017), Channels (Austin), 11, 178 - 180

• Overexpression of SERCA2a promotes cardiac sympathetic neurotransmission via abnormal endoplasmic reticulum and mitochondria Ca2+ regulation

  Shanks J. et al, (2017), Hypertension

• Sympathetic neurons are a powerful driver of myocyte function in cardiovascular disease.

  Larsen HE. et al, (2016), Sci Rep, 6

• C-type natriuretic peptide and natriuretic peptide receptor B signalling inhibits cardiac sympathetic neurotransmission and autonomic function.

  Buttgereit J. et al, (2016), Cardiovasc Res, 112, 637 - 644

• Challenges, Opportunities, and the Future of Physiological Publications in the Hype Cycle.

  Paterson DJ., (2016), Physiology (Bethesda), 31, 386 - 387

• Carotid sinus denervation ameliorates renovascular hypertension in adult Wistar rats.

  Pijacka W. et al, (2016), J Physiol, 594, 6255 - 6266

• Dysregulation of Neuronal Ca2+ Channel Linked to Heightened Sympathetic Phenotype in Prohypertensive States.

  Larsen HE. et al, (2016), J Neurosci, 36, 8562 - 8573

• Cardiac sympatho-vagal balance and ventricular arrhythmia.

  Kalla M. et al, (2016), Auton Neurosci, 199, 29 - 37

• Protection against ventricular fibrillation via cholinergic receptor stimulation and the generation of nitric oxide.

  Kalla M. et al, (2016), J Physiol, 594, 3981 - 3992

• Molecular and cellular neurocardiology: development, and cellular and molecular adaptations to heart disease.

  Habecker BA. et al, (2016), J Physiol, 594, 3853 - 3875

• Cyclic nucleotide regulation of cardiac sympatho-vagal responsiveness.

  Li D. and Paterson DJ., (2016), J Physiol, 594, 3993 - 4008

• Passing the baton.

  Paterson DJ., (2016), J Physiol, 594, 1503 - 1505

• CAN YOU TEACH AN OLD DOG NEW TRICKS? THE ANTIMALARIAL HYDROXYCHLOROQUINE SHOWS PROMISE IN CARDIAC RATE CONTROL THROUGH ACTIONS AT THE SINO-ATRIAL NODE

  Capel RA. et al, (2015), HEART, 101, A2 - A2

• Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential.

  Capel RA. et al, (2015), Heart Rhythm, 12, 2186 - 2194

• Insights gleaned from pharmaco-genetic dissection and modelling of cardio-respiratory neural networks.

  Paterson DJ. and Paton JF., (2015), J Physiol, 593

• Efficacy of B-Type Natriuretic Peptide Is Coupled to Phosphodiesterase 2A in Cardiac Sympathetic Neurons.

  Li D. et al, (2015), Hypertension, 66, 190 - 198

• Forward problem of electrocardiography: is it solved?

  Bear LR. et al, (2015), Circ Arrhythm Electrophysiol, 8, 677 - 684

• CAPON modulates neuronal calcium handling and cardiac sympathetic neurotransmission during dysautonomia in hypertension.

  Lu CJ. et al, (2015), Hypertension, 65, 1288 - 1297

• The Journal of Physiology annual report 2014-15: a year of change and celebration.

  Paterson DJ. and Howells S., (2015), J Physiol, 593, 1035 - 1044

• A Novel Role for B-Type Natriuretic Peptide and Phosphodiesterase 2A in Cardiac Sympathetic Neurons from Prehypertensive Rats

  Li D. et al, (2015), BIOPHYSICAL JOURNAL, 108, 106A - 107A

• Effect of global cardiac ischemia on human ventricular fibrillation: insights from a multi-scale mechanistic model of the human heart.

  Kazbanov IV. et al, (2014), PLoS Comput Biol, 10

• Enhancing NOS1 adaptor protein levels decreases intracellular calcium handling and neurotransmission in cardiac sympathetic neurons

  Lu C-J. et al, (2014), EUROPEAN HEART JOURNAL, 35, 524 - 524

• Beta-blockers do not prevent the pro-arrhythmic action of high-level sympathetic stimulation: a role for neuropeptide Y?

  Kalla M. et al, (2014), EUROPEAN HEART JOURNAL, 35, 259 - 259

• Differentiated baroreflex modulation of sympathetic nerve activity during deep brain stimulation in humans.

  Sverrisdóttir YB. et al, (2014), Hypertension, 63, 1000 - 1010

• The Journal of Physiology Annual Report 2013-14:Another year of progress.

  Paterson DJ. and Howells S., (2014), J Physiol, 592, 811 - 821

• The Journal of Physiology Annual Report 2013-14:Another year of progress.

  Paterson DJ. and Howells S., (2014), J Physiol, 592, 811 - 821

• Laterally resolved speciation of arsenic in roots of wheat and rice using fluorescence-XANES imaging

  Kopittke PM. et al, (2014), New Phytologist, 201, 1251 - 1262

• Defining the neurocircuitry of exercise hyperpnoea.

  Paterson DJ., (2014), J Physiol, 592, 433 - 444

• Defining the neurocircuitry of exercise hyperpnoea

  Paterson DJ., (2014), Journal of Physiology, 592, 433 - 444

• Differentiated baroreflex modulation of sympathetic nerve activity during deep brain stimulation in humans

  Sverrisdóttir YB. et al, (2014), Hypertension, 63, 1000 - 1010

• David H. Hubel MD FRS Nobel Laureate: a man of vision.

  Paterson DJ., (2014), J Physiol, 592

• Cardiac sympathetic dysfunction in the prehypertensive spontaneously hypertensive rat.

  Shanks J. et al, (2013), Am J Physiol Heart Circ Physiol, 305, H980 - H986

• Arrhythmia: 100 years on from George Ralph Mines.

  Paterson DJ., (2013), J Physiol, 591, 4065 - 4066

• Acetylcholine analogue mimics the protective effect of cardiac vagal nerve stimulation on ventricular fibrillation threshold

  Kalla M. et al, (2013), EUROPEAN HEART JOURNAL, 34, 925 - 925

• The Journal of Physiology Annual Report 2012-13. A year of progress

  Paterson DJ. et al, (2013), Journal of Physiology, 591, 593 - 599

• The Journal of Physiology Annual Report 2012-13: a year of progress.

  Paterson DJ. et al, (2013), J Physiol, 591, 593 - 599

• Targeted neuronal nitric oxide synthase transgene delivery into stellate neurons reverses impaired intracellular calcium transients in prehypertensive rats.

  Li D. et al, (2013), Hypertension, 61, 202 - 207

• Targeted neuronal nitric oxide synthase transgene delivery into stellate neurons reverses impaired intracellular calcium transients in prehypertensive rats

  Li D. et al, (2013), Hypertension, 61, 202 - 207

• Howard Florey and neuroscience.

  Donnan GA. and Paterson DJ., (2013), J Physiol, 591, 33 - 34

• Howard Florey and neuroscience

  Donnan GA. and Paterson DJ., (2013), Journal of Physiology, 591, 33 - 34

• Ganglion-specific impairment of the norepinephrine transporter in the hypertensive rat.

  Shanks J. et al, (2013), Hypertension, 61, 187 - 193

• Ganglion-specific impairment of the norepinephrine transporter in the hypertensive rat

  Shanks J. et al, (2013), Hypertension, 61, 187 - 193

• Adaption and responses: Myocardial innervations and neural control

  Herring N. and Paterson DJ., (2012), Muscle, 1, 261 - 271

• What can modelling provide to cardiac physiology?

  Smith NP. et al, (2012), J Physiol, 590, 4401 - 4402

• What can modelling provide to cardiac physiology?

  Smith NP. et al, (2012), Journal of Physiology, 590, 4401 - 4402

• Congratulations, APS! 125 and counting.

  Barrett KE. and Paterson DJ., (2012), J Physiol, 590, 1771 - 1772

• Peripheral Cardiac Sympathetic dysfunction in the pre-hypertensive Spontaneously Hypertensive Rat

  Shanks J. et al, (2012), FASEB JOURNAL, 26

• Congratulations, APS! 125 and counting...

  Barrett KE. and Paterson DJ., (2012), Journal of Physiology, 590, 1771 - 1772

• The cardiac sympathetic co-transmitter galanin reduces acetylcholine release and vagal bradycardia: implications for neural control of cardiac excitability.

  Herring N. et al, (2012), J Mol Cell Cardiol, 52, 667 - 676

• The cardiac sympathetic co-transmitter galanin reduces acetylcholine release and vagal bradycardia: Implications for neural control of cardiac excitability

  Herring N. et al, (2012), Journal of Molecular and Cellular Cardiology, 52, 667 - 676

• Abnormal intracellular calcium homeostasis in sympathetic neurons from young prehypertensive rats.

  Li D. et al, (2012), Hypertension, 59, 642 - 649

• Abnormal intracellular calcium homeostasis in sympathetic neurons from young prehypertensive rats

  Li D. et al, (2012), Hypertension, 59, 642 - 649

• Controlling the lungs via the brain: a novel neurosurgical method to improve lung function in humans.

  Hyam JA. et al, (2012), Neurosurgery, 70, 469 - 477

• Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin

  Adlam D. et al, (2012), Cardiovascular Research, 93, 694 - 701

• Abnormal intracellular calcium homeostasis in sympathetic neurons from young prehypertensive rats

  Li D. et al, (2012), Hypertension, 59, 642 - 649

• Telemetric analysis of haemodynamic regulation during voluntary exercise training in mouse models

  Adlam D. et al, (2011), Experimental Physiology, 96, 1118 - 1128

• Telemetric analysis of haemodynamic regulation during voluntary exercise training in mouse models.

  Adlam D. et al, (2011), Exp Physiol, 96, 1118 - 1128

• The Journal of Physiology at SfN 2011.

  Paterson DJ. and Huxley C., (2011), J Physiol, 589

• The Journal of Physiology at SfN 2011

  Paterson DJ. and Huxley C., (2011), Journal of Physiology, 589

• Human ventricular fibrillation during global ischemia and reperfusion: paradoxical changes in activation rate and wavefront complexity.

  Bradley CP. et al, (2011), Circ Arrhythm Electrophysiol, 4, 684 - 691

• Experiment-model interaction for analysis of epicardial activation during human ventricular fibrillation with global myocardial ischaemia.

  Clayton RH. et al, (2011), Prog Biophys Mol Biol, 107, 101 - 111

• Experiment-model interaction for analysis of epicardial activation during human ventricular fibrillation with global myocardial ischaemia

  Clayton RH. et al, (2011), Progress in Biophysics and Molecular Biology, 107, 101 - 111

• Depiction of the neuroscientific principles of human motion 2 millennia ago by Lucretius.

  Hyam JA. et al, (2011), Neurology, 77, 1000 - 1004

• Physiology: found in translation.

  Wagner PD. and Paterson DJ., (2011), Am J Physiol Renal Physiol, 301, F461 - F462

• Physiology: found in translation.

  Wagner PD. and Paterson DJ., (2011), Am J Physiol Heart Circ Physiol, 301, H627 - H628

• Physiology: found in translation.

  Wagner PD. and Paterson DJ., (2011), Am J Physiol Endocrinol Metab, 301, E427 - E428

• Physiology: Found in translation

  Wagner PD. and Paterson DJ., (2011), American Journal of Physiology - Renal Physiology, 301

• Physiology: found in translation

  Wagner PD. and Paterson DJ., (2011), AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 301, E427 - E428

• Physiology: Found in translation

  Wagner PD. and Paterson DJ., (2011), American Journal of Physiology - Heart and Circulatory Physiology, 301

• Physiology: Found in translation

  Wagner PD. and Paterson DJ., (2011), American Journal of Physiology - Endocrinology and Metabolism, 301

• Physiology: found in translation.

  Wagner PD. and Paterson DJ., (2011), J Physiol, 589, 3899 - 3900

• Controlling the Lungs via the Brain: A novel neurosurgical method to improve lung function in humans

  Hyam JA. et al, (2011), Neurosurgery

• A model of cellular cardiac-neural coupling that captures the sympathetic control of sinoatrial node excitability in normotensive and hypertensive rats

  Tao T. et al, (2011), Biophysical Journal, 101, 594 - 602

• Physiology: found in translation.

  Wagner PD. and Paterson DJ., (2011), J Appl Physiol (1985), 111, 333 - 334

• Physiology: Found in translation

  Wagner PD. and Paterson DJ., (2011), Journal of Applied Physiology, 111, 333 - 334

• Physiology: Found in translation

  Wagner PD. and Paterson DJ., (2011), Journal of Physiology, 589, 3899 - 3900

• The Journal of Physiology: over 130 years of communicating fundamental discovery in physiology.

  Paterson DJ., (2011), J Physiol, 589, 3049 - 3050

• Expression of concern.

  Paterson DJ., (2011), J Physiol, 589

• Statistics: all together now, one step at a time.

  Drummond GB. et al, (2011), Adv Physiol Educ, 35

• Statistics: all together now, one step at a time.

  Drummond GB. et al, (2011), Microcirculation, 18

• Statistics: all together now, one step at a time.

  Drummond GB. et al, (2011), Br J Pharmacol, 163

• Statistics: all together now, one step at a time.

  Drummond GB. et al, (2011), Exp Physiol, 96, 481 - 482

• Statistics: all together now, one step at a time.

  Drummond GB. et al, (2011), Br J Nutr, 105, 1285 - 1286

• Deep brain stimulation of the periaqueductal grey induces vasodilation in humans.

  Carter HH. et al, (2011), Hypertension, 57, e24 - e25

• Deep brain stimulation of the periaqueductal grey induces vasodilation in humans

  Carter HH. et al, (2011), Hypertension, 57

• Statistics: all together now, one step at a time.

  Drummond GB. et al, (2011), J Physiol, 589

• Identifying cardiovascular neurocircuitry involved in the exercise pressor reflex in humans using functional neurosurgery.

  Basnayake SD. et al, (2011), J Appl Physiol (1985), 110, 881 - 891

• Pravastatin normalises peripheral cardiac sympathetic hyperactivity in the spontaneously hypertensive rat

  Herring N. et al, (2011), Journal of Molecular and Cellular Cardiology, 50, 99 - 106

• ARRIVE: new guidelines for reporting animal research.

  Drummond GB. et al, (2010), Exp Physiol, 95

• ARRIVE: new guidelines for reporting animal research.

  Drummond GB. et al, (2010), J Physiol, 588

• Intra-operative deep brain stimulation of the periaqueductal grey matter modulates blood pressure and heart rate variability in humans.

  Green AL. et al, (2010), Neuromodulation, 13, 174 - 181

• Ventral periaqueductal grey stimulation alters heart rate variability in humans with chronic pain.

  Pereira EA. et al, (2010), Exp Neurol, 223, 574 - 581

• Pravastatin normalizes peripheral sympathetic hyperactivity in the Spontaneously Hypertensive Rat by reducing cardiac angiotensin 2 levels

  Herring N. et al, (2010), FASEB JOURNAL, 24

• Peripheral Cardiac Sympathetic dysfunction in the pre-hypertensive Spontaneously Hypertensive Rat

  Shanks J. et al, (2010), FASEB JOURNAL, 24

• Galanin reduces cardiac vagal acetylcholine release and bradycardia via a GalR1, protein kinase C dependent pathway

  Herring N. et al, (2010), FASEB JOURNAL, 24

• Experimental Physiology Annual Report 2009

  Paterson DJ., (2010), EXPERIMENTAL PHYSIOLOGY, 95, 398 - 399

• Sustained reduction of hypertension by deep brain stimulation.

  Pereira EA. et al, (2010), J Clin Neurosci, 17, 124 - 127

• Long-term effect of neuronal nitric oxide synthase over-expression on cardiac neurotransmission mediated by a lentiviral vector.

  Wang L. et al, (2009), J Physiol, 587, 3629 - 3637

• L-arginine supplementation reduces cardiac noradrenergic neurotransmission in spontaneously hypertensive rats.

  Lee CW. et al, (2009), J Mol Cell Cardiol, 47, 149 - 155

• The Cardiac Physiome: at the heart of coupling models to measurement.

  Smith NP. et al, (2009), Exp Physiol, 94, 469 - 471

• Organization of ventricular fibrillation in the human heart: experiments and models.

  ten Tusscher KH. et al, (2009), Exp Physiol, 94, 553 - 562

• Targeting cardiac sympatho-vagal imbalance using gene transfer of nitric oxide synthase.

  Danson EJ. et al, (2009), J Mol Cell Cardiol, 46, 482 - 489

• Identifying the Neurocircuitry Involved in the Exercise Pressor Reflex during Exercise in Humans

  Basnayake SD. et al, (2009), FASEB JOURNAL, 23

• Calcium Handling in Postganglionic Sympathetic Neurons is enhanced in Prehypertensive Spontaneously Hypertensive rat

  Li D. et al, (2009), FASEB JOURNAL, 23

• Neuromodulators of peripheral cardiac sympatho-vagal balance.

  Herring N. and Paterson DJ., (2009), Exp Physiol, 94, 46 - 53

• Epicardial mapping of ventricular fibrillation in the human heart during ischaemia and reperfusion

  Clayton RH. et al, (2008), Computers in Cardiology, 35, 1029 - 1032

• Pravastatin Reduces Peripheral Cardiac Noradrenergic Hyperactivity in Spontaneously Hypertensive Rats via Angiotensin II Pathway

  Lee CW. et al, (2008), CIRCULATION, 118, S549 - S549

• Cardiac cholinergic NO-cGMP signaling following acute myocardial infarction and nNOS gene transfer.

  Dawson TA. et al, (2008), Am J Physiol Heart Circ Physiol, 295, H990 - H998

• Effects of acute vagal nerve stimulation on the early passive electrical changes induced by myocardial ischaemia in dogs: heart rate-mediated attenuation.

  Del Rio CL. et al, (2008), Exp Physiol, 93, 931 - 944

• L-arginine Supplementation Reduces Local Cardiac Noradrenergic Neurotransmission in Spontaneously Hypertensive Rats

  Lee CW. et al, (2008), FASEB JOURNAL, 22

• Neuropeptide Y reduces acetylcholine release and vagal bradycardia via a Y2 receptor-mediated, protein kinase C-dependent pathway.

  Herring N. et al, (2008), J Mol Cell Cardiol, 44, 477 - 485

• Experimental physiology. Celebrating 100 years of publishing discovery in physiology 1908-2008.

  Paterson DJ., (2008), Exp Physiol, 93, 1 - 15

• Letter by Herring and Paterson regarding article, "Common NOS1AP variants are associated with a prolonged QTc interval in the Rotterdam Study".

  Herring N. and Paterson DJ., (2007), Circulation, 116

• Neuronal nitric oxide synthase gene transfer decreases [Ca2+]i in cardiac sympathetic neurons.

  Wang L. et al, (2007), J Mol Cell Cardiol, 43, 717 - 725

• Mobility of epicardial rotors during human ventricular fibrillation

  Nash MP. et al, (2007), CIRCULATION, 116, 278 - 278

• Lower mortality with direct right atrial neuronal nitric oxide synthase gene transfer in first three days post myocardial infarction

  Dawson TA. et al, (2007), CIRCULATION, 116, 53 - 53

• Long term effect of nNOS overexpression on cardiac neurotransmission mediated by lentiviral vector

  Wang L. et al, (2007), CIRCULATION, 116, 6 - 7

• Is human ventricular fibrillation different from experimental models?

  Nash MP. et al, (2007), CIRCULATION, 116, 278 - 278

• Noradrenergic cell specific gene transfer with neuronal nitric oxide synthase reduces cardiac sympathetic neurotransmission in hypertensive rats.

  Li D. et al, (2007), Hypertension, 50, 69 - 74

• Deep brain stimulation: a new treatment for hypertension?

  Green AL. et al, (2007), J Clin Neurosci, 14, 592 - 595

• Identifying cardiorespiratory neurocircuitry involved in central command during exercise in humans

  Green A. et al, (2007), FASEB JOURNAL, 21, A566 - A566

• Gene transfer of neuronal nitric oxide synthase into intracardiac Ganglia reverses vagal impairment in hypertensive rats.

  Heaton DA. et al, (2007), Hypertension, 49, 380 - 388

• Identifying cardiorespiratory neurocircuitry involved in central command during exercise in humans.

  Green AL. et al, (2007), J Physiol, 578, 605 - 612

• Epicardial ECG mapping of human ventricular fibrillation

  Mourad A. et al, (2006), IET Conference Publications

• Stimulating the human midbrain to reveal the link between pain and blood pressure.

  Green AL. et al, (2006), Pain, 124, 349 - 359

• Multifractal ECG mapping of ventricular epicardium during regional ischemia in the pig.

  Chen Y. et al, (2006), IEEE Trans Biomed Eng, 53, 1920 - 1925

• Remodeling of the cardiac pacemaker L-type calcium current and its beta-adrenergic responsiveness in hypertension after neuronal NO synthase gene transfer.

  Heaton DA. et al, (2006), Hypertension, 48, 443 - 452

• Evidence for multiple mechanisms in human ventricular fibrillation.

  Nash MP. et al, (2006), Circulation, 114, 536 - 542

• Noradrenergic neuron-specific overexpression of nNOS in cardiac sympathetic nerves decreases neurotransmission.

  Wang L. et al, (2006), J Mol Cell Cardiol, 41, 364 - 370

• A novel technique for advanced exercise phenotyping in mouse models

  De Bono JP. et al, (2006), EUROPEAN HEART JOURNAL, 27, 259 - 259

• Controlling the heart via the brain: a potential new therapy for orthostatic hypotension.

  Green AL. et al, (2006), Neurosurgery, 58, 1176 - 1183

• Reactive oxygen species and autonomic regulation of cardiac excitability.

  Danson EJ. and Paterson DJ., (2006), J Cardiovasc Electrophysiol, 17 Suppl 1, S104 - S112

• The SARD variety of multifractality of ventricular epicardial mapping during ischemia

  Chen Y. et al, (2006), Chinese Science Bulletin, 51, 809 - 814

• Novel quantitative phenotypes of exercise training in mouse models.

  De Bono JP. et al, (2006), Am J Physiol Regul Integr Comp Physiol, 290, R926 - R934

• ECG diagnosis of acute ischaemia and infarction: past, present and future.

  Herring N. and Paterson DJ., (2006), QJM, 99, 219 - 230

• Mechanisms of galanin inhibition of cardiac parasympathetic transmission

  Habecker BA. et al, (2006), FASEB JOURNAL, 20, A1201 - A1202

• Whole heart action potential duration restitution properties in cardiac patients: a combined clinical and modelling study.

  Nash MP. et al, (2006), Exp Physiol, 91, 339 - 354

• Functional Neurosurgery Resident Award: controlling the cardiovascular system with deep brain stimulation.

  Green AL. et al, (2006), Clin Neurosurg, 53, 316 - 323

• Neural Control of Cardiac Function

  Paterson DJ. and Coote JH., (2005), Peripheral Neuropathy, 1, 217 - 231

• Deep brain stimulation can regulate arterial blood pressure in awake humans.

  Green AL. et al, (2005), Neuroreport, 16, 1741 - 1745

• Early ventricular fibrillation in the human heart is sustained by a small number of re-entrant sources

  Mourad A. et al, (2005), CIRCULATION, 112, U131 - U131

• Disruption of inhibitory G-proteins mediates a reduction in atrial beta-adrenergic signaling by enhancing eNOS expression.

  Danson EJ. et al, (2005), Cardiovasc Res, 67, 613 - 623

• Targeting arterial chemoreceptor over-activity in heart failure with a gas.

  Paterson DJ., (2005), Circ Res, 97, 201 - 203

• Periventricular gray area stimulation can regulate arterial blood pressure in awake humans

  Green AL. et al, (2005), NEUROSURGERY, 57, 424 - 424

• Targeted nNOS gene transfer into the cardiac vagus rapidly increases parasympathetic function in the pig.

  Heaton DA. et al, (2005), J Mol Cell Cardiol, 39, 159 - 164

• Cardiac neurobiology of nitric oxide synthases.

  Danson EJ. and Paterson DJ., (2005), Ann N Y Acad Sci, 1047, 183 - 196

• Tetrahydrobiopterin regulates vagal control of heart rate

  Adlam D. et al, (2005), HEART, 91, A57 - A57

• Autonomic remodelling in hypertension following cardiac neural nitric oxide synthase (nNOS) gene transfer

  Heaton DA. et al, (2005), HEART, 91, A65 - A65

• Cardiac nitric oxide: emerging role for nNOS in regulating physiological function.

  Danson EJ. et al, (2005), Pharmacol Ther, 106, 57 - 74

• Impairment of cholinergic signaling reduces atrial beta-adrenergic responsiveness by enhancing eNOS expression

  Zhang YH. et al, (2004), CIRCULATION, 110, 293 - 293

• Adenoviral nNOS gene transfer into the cardiac vagus increases protein expression within 9 hours and enhances vagal responsiveness in the pig

  Paterson DJ. et al, (2004), CIRCULATION, 110, 200 - 200

• Impaired regulation of neuronal nitric oxide synthase and heart rate during exercise in mice lacking one nNOS allele.

  Danson EJ. et al, (2004), J Physiol, 558, 963 - 974

• Cardiac nNOS gene transfer decreases beta-adrenergic chronotropic hyper-responsiveness by modulating I-CaL in spontaneously hypertensive rats

  Heaton DA. et al, (2004), FASEB JOURNAL, 18, A1076 - A1076

• Targeting neuronal nitric oxide synthase with gene transfer to modulate cardiac autonomic function.

  Mohan RM. et al, (2004), Prog Biophys Mol Biol, 84, 321 - 344

• Impaired regulation of neuronal nitric oxide synthase during exercise abolishes training-induced facilitation of cardiac vagal function in mice lacking one nNOS allele

  Danson EJ. et al, (2003), CIRCULATION, 108, 57 - 57

• Cardiac nNOS gene transfer decreases beta-adrenergic - Hyper-Responsiveness and enhances vagal function in spontaneously hypertensive rats

  Heaton DA. et al, (2003), CIRCULATION, 108, 184 - 184

• The mechanism underlying the positive inotropic effect of angiotensin II in the isolated perfused rabbit heart: a 31P NMR study.

  Mielke M. et al, (2003), Int J Biochem Cell Biol, 35, 984 - 991

• Imaging electrocardiographic dispersion of depolarization and repolarization during ischemia: simultaneous body surface and epicardial mapping.

  Nash MP. et al, (2003), Circulation, 107, 2257 - 2263

• Enhanced neuronal nitric oxide synthase expression is central to cardiac vagal phenotype in exercise-trained mice.

  Danson EJ. and Paterson DJ., (2003), J Physiol, 546, 225 - 232

• Neuronal nitric oxide synthase gene transfer promotes cardiac vagal gain of function.

  Mohan RM. et al, (2002), Circ Res, 91, 1089 - 1091

• Nitric oxide and autonomic control of heart rate: a question of specificity.

  Paton JF. et al, (2002), Trends Neurosci, 25, 626 - 631

• Inhibition of Gi causes NOS-III dependent attenuation of inotropic and chronotropic responses to beta-adrenergic stimulation in murine atria in-vitro

  Danson EJ. et al, (2002), CIRCULATION, 106, 293 - 293

• Enhanced NOS-1 expression with gene transfer promotes cardiac vagal gain of function

  Mohan RM. et al, (2002), CIRCULATION, 106, 293 - 293

• Enhanced neuronal nitric oxide synthase is central to cardiac vagal phenotype following exercise-training in mice

  Danson EJ. et al, (2002), CIRCULATION, 106, 175 - 175

• Torso mapping can identify changes in ventricular activation-recovery intervals during regional ischaemia that are not detected using the electrocardiogram in the anaesthetised pig

  Nash MP. et al, (2002), JOURNAL OF PHYSIOLOGY-LONDON, 544, 45P - 46P

• Cholinergic control of heart rate by nitric oxide is site specific.

  Herring N. et al, (2002), News Physiol Sci, 17, 202 - 206

• An experimental model to correlate simultaneous body surface and epicardial electropotential recordings in vivo

  Nash MP. et al, (2002), Chaos, Solitons and Fractals, 13, 1735 - 1742

• Endothelial nitric oxide synthase and heart rate.

  Herring N. and Paterson DJ., (2002), Circulation, 106

• Particulate guanylyl cyclase and cholinergic control of cardiac excitability is site specific [2] (multiple letters)

  Herring N. et al, (2002), Cardiovascular Research, 54, 697 - 700

• Particulate guanylyl cyclase and cholinergic control of cardiac excitability is site specific.

  Herring N. et al, (2002), Cardiovasc Res, 54, 697 - 698

• Expression of NO synthase and guanylate cyclase in the NTS during hypertension

  Mohan RM. et al, (2002), FASEB JOURNAL, 16, A1117 - A1117

• Electrical stimulation of the midbrain increases heart rate and arterial blood pressure in awake humans.

  Thornton JM. et al, (2002), J Physiol, 539, 615 - 621

• Peripheral vagal control of heart rate is impaired in neuronal NOS knockout mice.

  Choate JK. et al, (2001), Am J Physiol Heart Circ Physiol, 281, H2310 - H2317

• NO-cGMP pathway increases the hyperpolarisation-activated current, I(f), and heart rate during adrenergic stimulation.

  Herring N. et al, (2001), Cardiovasc Res, 52, 446 - 453

• Natriuretic peptides like NO facilitate cardiac vagal neurotransmission and bradycardia via a cGMP pathway.

  Herring N. et al, (2001), Am J Physiol Heart Circ Physiol, 281, H2318 - H2327

• NO-cGMP pathway enhances the heart rate response to peripheral vagal nerve stimulation in exercise trained mice

  Danson EJF. et al, (2001), JOURNAL OF PHYSIOLOGY-LONDON, 536, 81P - 82P

• No-cGMP pathway enhances the heart rate response to peripheral vagal nerve stimulation in exercise trained mice

  Danson EJF. et al, (2001), CIRCULATION, 104, 173 - 173

• Noninvasive electrical imaging of the heart: theory and model development.

  Pullan AJ. et al, (2001), Ann Biomed Eng, 29, 817 - 836

• Nitric oxide-cGMP pathway facilitates acetylcholine release and bradycardia during vagal nerve stimulation in the guinea-pig in vitro.

  Herring N. and Paterson DJ., (2001), J Physiol, 535, 507 - 518

• Intermittent hypoxia modulates nNOS expression and heart rate response to sympathetic nerve stimulation.

  Mohan RM. et al, (2001), Am J Physiol Heart Circ Physiol, 281, H132 - H138

• Identification of higher brain centres that may encode the cardiorespiratory response to exercise in humans.

  Thornton JM. et al, (2001), J Physiol, 533, 823 - 836

• Intermittent hypoxia improves atrial tolerance to subsequent anoxia and reduces stress protein expression.

  Mohan RM. et al, (2001), Acta Physiol Scand, 172, 89 - 95

• Spatio-temporal evolution of electrical activity recorded concurrently from the epicardium and body surface during cardiac ischaemia in the anaesthetised pig

  Bradley CP. et al, (2001), JOURNAL OF PHYSIOLOGY-LONDON, 533, 24P - 25P

• NO-cGMP pathway increases the hyperpolarisation-activated current (I-f) and heart rate during adrenergic stimulation in the guinea-pig in vitro

  Herring N. et al, (2001), JOURNAL OF PHYSIOLOGY-LONDON, 533, 35P - 35P

• NO-cGMP pathway facilitates vagal neurotransmission and bradycardia

  Herring N. and Paterson DJ., (2001), FASEB JOURNAL, 15, A780 - A780

• Intermittent hypoxia reduces nNOS expression and increases the heart rate response to cardiac sympathetic nerve stimulation in-vitro

  Mohan RM. et al, (2001), FASEB JOURNAL, 15, A470 - A470

• Impaired cardiac vagal activation and down regulation of atrial guanylate cyclase in the spontaneously hypertensive rat.

  Almond S. and Paterson DJ., (2001), FASEB JOURNAL, 15, A473 - A473

• Ventricular activation during sympathetic imbalance and its computational reconstruction.

  Nash MP. et al, (2001), J Appl Physiol (1985), 90, 287 - 298

• The effect of cardiac autonomic denervation on T wave alternans following exercise

  Qayyum MS. et al, (2001), British Journal of Cardiology, 8, 231 - 232+234+236+238

• Raised extracellular potassium attenuates the sympathetic modulation of sino-atrial node pacemaking in the isolated guinea-pig atria.

  Choate JK. et al, (2001), Exp Physiol, 86, 19 - 25

• Nitric oxide and the autonomic regulation of cardiac excitability. The G.L. Brown Prize Lecture.

  Paterson D., (2001), Exp Physiol, 86, 1 - 12

• Sulphonylurea-sensitive channels and NO-cGMP pathway modulate the heart rate response to vagal nerve stimulation in vitro.

  Almond SC. and Paterson DJ., (2000), J Mol Cell Cardiol, 32, 2065 - 2073

• Vagal modulation of heart rate in the neuronal nitric oxide synthase knock-out mouse in vitro

  Choate JK. et al, (2000), CIRCULATION, 102, 128 - 129

• Role of cGMP-inhibited phosphodiesterase and sarcoplasmic calcium in mediating the increase in basal heart rate with nitric oxide donors.

  Musialek P. et al, (2000), J Mol Cell Cardiol, 32, 1831 - 1840

• Pre-synaptic NO-cGMP pathway modulates vagal control of heart rate in isolated adult guinea pig atria.

  Herring N. et al, (2000), J Mol Cell Cardiol, 32, 1795 - 1804

• Peripheral pre-synaptic pathway reduces the heart rate response to sympathetic activation following exercise training: role of NO.

  Mohan RM. et al, (2000), Cardiovasc Res, 47, 90 - 98

• Activation of sulphonylurea-sensitive channels and the NO-cGMP pathway decreases the heart rate response to sympathetic nerve stimulation.

  Mohan RM. and Paterson DJ., (2000), Cardiovasc Res, 47, 81 - 89

• cGMP-inhibited phosphodiesterase of cAMP (PDE3) and protein kinase a (PKA) play an important role in eliciting the positive chronotropic effect of Nitric Oxide (NO) donors

  Musialek P. et al, (2000), Heart, 83

• NO-cGMP dependent pathway and the modulation of vagal control of heart rate

  Herring N. et al, (2000), FASEB JOURNAL, 14, A377 - A377

• Higher centres encode cardiorespiratory response to exercise without movement feedback

  Paterson DJ. et al, (2000), FASEB JOURNAL, 14, A646 - A646

• Electrocardiographic inverse validation study: Model development and methodology

  Bradley CP. et al, (2000), FASEB JOURNAL, 14, A442 - A442

• Electrocardiographic inverse validation study: In-vivo mapping and analysis

  Nash MP. et al, (2000), FASEB JOURNAL, 14, A442 - A442

• Chronic intermittent hypoxia promotes differential expression of stress proteins following in vitro hypoxia in guinea pig hearts.

  Golding S. et al, (2000), FASEB JOURNAL, 14, A586 - A586

• Activation of K-ATP channels and NO-cGMP pathway decrease the heart rate response to sympathetic nerve stimulation in vitro.

  Mohan RM. and Paterson DJ., (2000), FASEB JOURNAL, 14, A398 - A398

• The nitric oxide donor sodium nitroprusside increases heart rate in the absence of changes in arterial blood pressure when applied topically to the sino-atrial node in the anaesthetised pig

  Musialek P. et al, (2000), JOURNAL OF PHYSIOLOGY-LONDON, 523, 267P - 268P

• Should we still use nitrovasodilators to test baroreflex sensitivity?

  Casadei B. and Paterson DJ., (2000), J Hypertens, 18, 3 - 6

• Cyclic GMP-inhibited phosphodiesterase of cAMP and protein kinase A play an important part in the positive chronotropic response to NO donors

  Musialek P. et al, (2000), EUROPEAN HEART JOURNAL, 21, 47 - 47

Key Publications

• Noradrenergic cell specific gene transfer with neuronal nitric oxide synthase reduces cardiac sympathetic neurotransmission in hypertensive rats.

  Li D. et al, (2007), Hypertension, 50, 69 - 74

• Remodeling of the cardiac pacemaker L-type calcium current and its beta-adrenergic responsiveness in hypertension after neuronal NO synthase gene transfer.

  Heaton DA. et al, (2006), Hypertension, 48, 443 - 452

• Enhanced neuronal nitric oxide synthase expression is central to cardiac vagal phenotype in exercise-trained mice.

  Danson EJ. and Paterson DJ., (2003), J Physiol, 546, 225 - 232

• Neuronal nitric oxide synthase gene transfer promotes cardiac vagal gain of function.

  Mohan RM. et al, (2002), Circ Res, 91, 1089 - 1091

Recent Publications

• Impaired cAMP-cGMP cross-talk during cardiac sympathetic dysautonomia.

  Bardsley EN. et al, (2017), Channels (Austin), 11, 178 - 180

• Overexpression of SERCA2a promotes cardiac sympathetic neurotransmission via abnormal endoplasmic reticulum and mitochondria Ca2+ regulation

  Shanks J. et al, (2017), Hypertension

• Sympathetic neurons are a powerful driver of myocyte function in cardiovascular disease.

  Larsen HE. et al, (2016), Sci Rep, 6

• C-type natriuretic peptide and natriuretic peptide receptor B signalling inhibits cardiac sympathetic neurotransmission and autonomic function.

  Buttgereit J. et al, (2016), Cardiovasc Res, 112, 637 - 644

• Challenges, Opportunities, and the Future of Physiological Publications in the Hype Cycle.

  Paterson DJ., (2016), Physiology (Bethesda), 31, 386 - 387