Postdoctoral Research Scientist
I was always interested in how things work and when I was a child it led to pile of broken toys. Later I could divert this trait to more constructive direction and became a cell biologist with interest in molecular oncology and physiology.
In 1998 I started to study an interdisciplinary subject of Biomedical Physics in Comenius University (Bratislava, Slovakia), which suited better my broad interest in natural sciences. I have successfully finished my master’s degree in 2002 with distinctions.
Then I joined laboratory of Professors Silvia Pastorekova and Jaromir Pastorek in Virological Institute of Slovak Academy of Sciences (Bratislava, Slovakia). It was laboratory focusing on the role of carbonic anhydrase IX in tumour biology as Silvia and Jaromir Pastoreks were first to identify the CAIX protein. I was lucky to work with lot of great and inspiring colleagues who gave me great background in molecular oncology research. In 2009 I have finished my PhD degree under Silvia’s supervision with thesis title “Role of pH regulation in oncogenesis and viral infection”.
In February 2009 I have moved to Oxford to join the lab of Pawel Swietach and stayed in Pawel’s lab as postdoctoral scientist in Department of Physiology, Anatomy and Genetics of Oxford University and stayed since.
We worked together on three 3-year projects. First project was focused on “Mechanisms, consequences and regulation of pH non-uniformity in 3-D tissue structures: implications on cancer therapy”. The second one was about “Regulation of cancer cell pH by stromal fibroblasts: studies of novel cancer-stroma interactions”. Between 2015 and 2016, I briefly joined Konstantinos Lefkimmiatis and helped with the project “Programmed necrosis in the development of heart disease: involvement of the AMP/PKA axis”.
Current project started in 2017 and again is supervised by Pawel Swietach. This project is focused at “Regulation of nuclear pH in ventricular myocytes and its role in gene expression”.
Based on recommendation from Pawel Swietach, I was awarded a College lectureship in Biomedical Sciences in Corpus Christi College (Oxford, UK) in 2012 and my college lectureship was renewed every year since 2012.
Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter anion exchanger 2, SLC4A2.
Michl J. et al, (2023), Cell Rep, 42
Detection of Intravascular Hemolysis in Newborn Infants Using Urinary Carbonic Anhydrase I Immunoreactivity.
Hulikova A. et al, (2020), J Appl Lab Med, 5, 921 - 934
Single-cell O2 exchange imaging shows that cytoplasmic diffusion is a dominant barrier to efficient gas transport in red blood cells.
Richardson SL. et al, (2020), Proc Natl Acad Sci U S A, 117, 10067 - 10078