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The annual Burdon Sanderson Prize lecture, given this year by Professor Richard W. Tsien, a pioneer in the study of calcium channels and synaptic transmission, is held in honour of John Burdon Sanderson (1828 - 1905), the University of Oxford's first Waynflete Professor of Physiology, after whom the Cardiac Centre is named.

Head of Department Professor David Paterson presents Burdon Sanderson Prize Medal to Professor Richard Tsien

On Monday 17 October 2022, the Department hosted the annual John Burdon Sanderson Prize Lecture, dedicated to its first Waynflete Professor of Physiology Sir John Burdon Sanderson, who was appointed in 1882. This year's lecture was entitled "Synaptic plasticity, calcium regulation and Alzheimer’s diseaseby DPAG alumni Richard W. Tsien, Druckenmiller Professor of Neuroscience, Chair of the Department of Physiology and Neuroscience, and Director of the NYU Neuroscience Institute at New York University Medical Center.

The Department was delighted to welcome back Professor Tsien, a former graduate student who came to Oxford on a prestigious Rhodes Scholarship. He graduated with a DPhil in Biophysics in 1970, working under the mentorship of Professors Denis Noble FRS and Julian Jack. He also notably worked with Jean Banister, the first woman to be appointed Departmental Demonstrator at the Laboratory of Physiology. Professor Tsien's doctoral thesis with Professor Noble described outward currents that support the cardiac action potential repolarization and repetitive firing. He also worked with Professors Jack and Noble on a seminal book now on numerous biophysics reading lists for students, 'Electric Current Flow in Excitable Cells' (Adler, 2015).

Professor Tsien is a world leader in the study of calcium channels and neurotransmission. His work has shed light on how synapses contribute to neuronal computation and network function in both the healthy and diseased brain. His research, published in over 200 peer-reviewed journal articles, has substantially contributed to furthering our understanding of how neurotransmitters, drugs and molecular alterations regulate calcium channels and has implications for diverse clinical areas such as pain and autism. 

Prior to Professor Tsien's lecture, the Department was treated to The Physiological Society Roadshow with talks from President Elect Professor David Attwell FRS, CEO Dariel Burdass, and Professor Noble. Following the final talk, Professor Tsien was delighted to honour his former mentor by unveiling Professor Denis Noble's portrait before witnessing his unveiling of The Physiological Society Sir John Burdon Sanderson Blue Plaque.

Following the unveilings, Professor Tsien delivered his lecture to a packed Blakemore Lecture Theatre. He began with an fascinating insight into his time at the Department under the mentorship of Professor Noble. He outlined some of Professor Noble's key scientific lessons, which included words of wisdom such as 'don't be fazed if it's more complex than others expect' and 'accept controversy as part of science'. 

Richard Tsien Burdon Sanderson Prize Lecture slides

His subsequent scientific lecture demonstrated fully how he took these lessons forward with his pioneering research. Homeostatic regulation of synapses is vital for healthy nervous system function. Activity-dependent synaptic scaling, an intensely studied form of homeostasis, is proposed to operate over hours to counteract the destabilizing influence of long-term potentiation (LTP) and long-term depression (LTD). The prevailing view holds that synaptic scaling is a slow first-order process that regulates postsynaptic glutamate receptors and fundamentally differs from LTP or LTD. The Tsien Lab's experiments challenge these presumptions. Surprisingly, the dynamics of scaling induced by neuronal inactivity are not exponential or monotonic and the mechanism requires calcineurin and CaMKII, molecules dominant in LTD and LTP. His lab's quantitative model of the interplay between these enzymes reconstructs the unexpected dynamics of homeostatic scaling and reveals how synapses efficiently safeguard future capacity for synaptic plasticity on demand. The modeling also provides a framework for understanding Alzheimer’s disease and how calcium dysregulation in AD might cause disruption of synaptic homeostasis. His team's human genetics-based experiments in mouse models of Alzheimer’s implicate this kind of pathophysiological connection.

The lecture was followed by a reception in Sherrington Building Reception Foyer.

Burdon Sanderson Lecture 2022 Drinks Reception in Sherrington

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