Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we will assume that you are happy to receive all cookies and you will not see this message again. Click 'Find out more' for information on how to change your cookie settings.

The Lecture is given every year by an established investigator in the field of cardiac metabolism at the Society for Heart and Vascular Metabolism conference in honour of the Society's founding father.

On Wednesday 26 June 2019, Professor Kieran Clarke delivered the annual "William C. Stanley" Award Lecture entitled Exogenus ketones for the Heart? at the 17th Annual Society for Heart and Vascular Metabolism Conference in Amsterdam. The Lecture is delivered each year in honour of William C. Stanley, the founding father of the SHVM, who passed away in 2013. The theme of this year's conference was targeting metabolic pathways to treat cardiovascular diseases.

In the past few years, a number of human and animal studies have suggested that an increase in ketone metabolism may benefit the failing heart. In her talk, Professor Clarke discussed the ketone bodies, d-β-hydroxybutyrate and acetoacetate, which are not found in large amounts in the human diet, but are produced in the liver from free fatty acids as an alternative energy supply for the brain, heart and skeletal muscle, in response to low blood glucose and insulin levels caused by fasting or a ketogenic diet.

In 2003, Professor Clarke and her team invented a new food group based on ketone metabolism, a ketone ester that they called ΔG®. As the ester is broken down slowly in the gut, it directly raises circulating d-β-hydroxybutyrate levels, overcoming the need for fasting or a ketogenic diet. A single ΔG® drink can raise circulating ketone levels to those found after several days of fasting or a ketogenic diet, and levels remain elevated for several hours following a drink. Professor Clarke's team have run many human studies of ΔG®. Their study in patients with type 2 diabetes found that three ΔG® drinks a day for five days normalised fast blood glucose, triglycerides and cholesterol levels. Her lecture also outlined the story of how ΔG®  developed to the point at which they have scaled up production to many tons for sale in the US.

 

Earlier in the conference, on Tuesday 25 June, Matthew Kerr, BHF DPhil student in the Heather Group, was awarded the William C. Stanley Early Investigator Award, which is given in honour of the founder's priority towards the support and mentoring of early investigators. Matthew delivered a talk entitled Energetic dysfunction in the type 2 diabetic myocardium is rescued by the deacetylase activator honokiol.

Earlier that day, Matthew's supervisor, Associate Professor Lisa Heather took part in a session tackling metabolic targets to combat cardiac IR injury, delivering a talk entitled Targeting metabolism to reduce cardiac IR injury in diabetes.

 

Similar stories

Gero Miesenböck to deliver The Physiological Society's Annual Review Prize Lecture

Awards and Honours CNCB

The Annual Review Prize Lecture is The Physiological Society's most prestigious lecture.

New research grant to Pawel Swietach to further understanding of propionic acidemia

Awards and Honours Cardiac Theme

A new collaborative project led by the Swietach group funded by the Propionic Acidemia Foundation will investigate the disease mechanisms and risk factors for cardiac disease caused by a severe inherited disorder.

Two DPAG pioneers honoured on Sherrington Building Plaques

EDI News Head of Department's News

Honouring the heritage of pioneering physiologists Sir Charles Sherrington and Florence Buchanan. "Commemorating both pioneers together highlights the importance of advocacy and mentoring that was evident over a century ago as equality was championed." (David Paterson)

Celebrating International Women's Day

EDI News

100 years since women were admitted as full members of the University of Oxford, women now hold vital posts at all levels of this institution. Meet six amazing women from DPAG.