Kieran Clarke
PhD
Emeritus Professor of Physiological Biochemistry
Since 1991, Professor Kieran Clarke has worked at the University of Oxford on the effects of diet on energy metabolism in human heart, brain and skeletal muscle. Specifically, her interest in physical and cognitive function has led to the development of a fourth food group, a ketone ester called ΔG®, that improves endurance exercise in athletes and could be used for the management of common metabolic diseases, such as type 2 diabetes.
Before Oxford, Professor Clarke worked as a postdoctoral fellow at Harvard University Medical School and as a research scientist at the NRC in Ottawa, Canada.
Key publications
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Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes.
Journal article
Cox PJ. et al, (2016), Cell Metab, 24, 256 - 268
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Prior ingestion of exogenous ketone monoester attenuates the glycaemic response to an oral glucose tolerance test in healthy young individuals.
Journal article
Myette-Côté É. et al, (2018), J Physiol, 596, 1385 - 1395
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Novel ketone diet enhances physical and cognitive performance.
Journal article
Murray AJ. et al, (2016), FASEB J, 30, 4021 - 4032
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On the Metabolism of Exogenous Ketones in Humans.
Journal article
Stubbs BJ. et al, (2017), Front Physiol, 8
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Ketone bodies mimic the life span extending properties of caloric restriction.
Journal article
Veech RL. et al, (2017), IUBMB Life, 69, 305 - 314
Recent publications
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Brain aging shows nonlinear transitions, suggesting a midlife "critical window" for metabolic intervention.
Journal article
Antal BB. et al, (2025), Proc Natl Acad Sci U S A, 122