Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we will assume that you are happy to receive all cookies and you will not see this message again. Click 'Find out more' for information on how to change your cookie settings.
Laura's image that made the front cover: cortical slow waves in sleeping young and older mice

Congratulations to Laura McKillop, a DPhil student within the Vyazovskiy Group, whose first author publication has made it to the front cover article of the 16th issue of the Journal of Neuroscience! 

According to the study of young and old mice carried out by Laura and her colleagues, the brain maintains its ability to generate local neural oscillations during sleep throughout the lifespan. The research indicates that age-related disruptions in sleep and associated large-scale brain activity, are not due to changes in the activity of individual neurons.

The paper recorded neural activity from deep layers of the motor cortex of groups of mice at different stages of life: early adulthood (5 months), late adulthood (12 months) and old age (24 months). The old age mice in this study are estimated to correspond to an age of roughly 70-years in humans.

The researchers did not find any major differences in the cortical neural activity during sleep across the three age groups. All mice also showed similar effects of sleep deprivation on local sleep oscillations in the neocortex. These findings contrast with previous studies both in mice and humans showing that ageing is associated with a reduced capacity to generate deep sleep, and highlight the need to consider activity at the level of individual neurons, in addition to the whole-brain view, in order to fully understand the effects of ageing on sleep.

Find out more about the research that goes on in the Vyazovskiy Group here.

Similar stories

Just over half of British Indians would take COVID vaccine

EDI News Outreach Postdoctoral Publication Research Riley Group News

University of Oxford researchers from the Department of Physiology, Anatomy and Genetics (DPAG) and the Department of Psychiatry, in collaboration with The 1928 Institute, have published a major new study on the impact of COVID-19 on the UK’s largest BME population.

Thomas Willis (1621 - 1675) 400th Birthday - Alastair Buchan in conversation with Zoltán Molnár

General Research

Professor Zoltán Molnár talks to Pro-Vice-Chancellor Professor Alastair Buchan to learn more about Thomas Willis's residence and base for scientific discoveries, Beam Hall.

Thomas Willis (1621 - 1675) 400th Birthday - Erica Charters in conversation with Zoltán Molnár

General Research

Professor Zoltán Molnár talks to Dr Erica Charters for a History of Medicine perspective on Oxford physician and Father of Neurology Thomas Willis.

Thomas Willis 400th anniversary trailer

General Research

On 27 January 2021 we celebrate the 400th anniversary of the birth of the greatest neuroanatomist of all time, Thomas Willis. DPAG's Professor Zoltán Molnár has interviewed 8 experts - watch a video preview of what's to come from Monday onwards! With thanks to St John's College.

Earliest origins of the forming heart identified

Cardiac Theme Postdoctoral Publication Research

The earliest known progenitor of the outermost layer of the heart has been characterised for the first time and linked to the development of other critical cell types in the developing heart in a new paper from the Srinivas group led by BHF Immediate Fellow Dr Richard Tyser.

Lukas Krone to represent Oxford at the Global Young Scientists Summit

Awards and Honours EDI News Head of Department's News Students Vyazovskiy Group News

Congratulations are in order for Dr Lukas Krone who is one of just five University of Oxford researchers selected to attend the Global Young Scientists Summit 2021.