Postdoctoral Research Scientist Dr Matthew Stower was selected to give a talk at the joint annual meeting of the BSDB and BDCB held at Warwick University from 3 - 6 April 2022.
Dr Stower presented a poster of his research entitled "Single-cell phenomics reveals behavioural & mechanical heterogeneities underpinning migratory activity during mouse anterior patterning", and became runner-up in the post-doc poster competition, receiving £100 prize money.
Dr Stower's poster and talk outlined research that reveals for the first time the cellular events underlying a migratory event in the early mouse embryo that is essential for normal development. To do this, Dr Stower and his team in DPAG's Srinivas Group generated a high resolution timelapse dataset using lightsheet imaging and developed a novel quantitative single-cell analysis approach they term "single-cell Phenomics" to analyse the phenotypes of epithelial cells throughout the migratory event.
Dr Stower said: "We believe this method will be useful to the research community as it provides an analytical framework for understanding complex multi-dimensional data."
The method is detailed in a recent Spotlight review article authored by Dr Matthew Stower and Professor Shankar Srinivas entitled "Advances in live imaging early mouse development: exploring the researcher's interdisciplinary toolkit", available to read in Volume 148, Issue 18 of Development.