- Zaccolo Group Research Group
Professor of Cell Biology and Deputy Head of Department
Manuela Zaccolo graduated in medicine at the University of Torino, Italy, and subsequently went on to pursue a career in science by spending four years as a post-doctoral researcher at the LMB, MRC, Cambridge, UK, working on protein engineering and in vitro molecular evolution. She then moved back to Italy, at the University of Padova, to work on the generation of fluorescent sensors for real time imaging of intracellular second messengers in living cells. In Padova she established her independent research group in 2001 at the Venetian Institute of Molecular Medicine with a focus on intracellular signalling. In 2007 she moved to the University of Glasgow, where she initially held a position as a Reader and subsequently as Professor of Cell Biology. In 2012 she joined the Department of Physiology, Anatomy and Genetics at Oxford University. She is also a Fellow in Pre-Clinical Medicine at Balliol College.
Manuela Zaccolo's research focuses on how cells sense external stimuli and how these are processed to produce a functional outcome. She is interested in the architectural and regulatory principles by which intracellular signalling networks achieve the plasticity and context-sensitivity necessary for a cell to function. In particular, her work has focused on cyclic nucleotide signalling in the heart and in other cell systems and on the role of local regulation and compartmentalisation of signal transduction in determining the specificity of cellular responses. Her ultimate goal is to understand how alteration of signalling networks leads to human disease and to apply this knowledge to the development of novel therapeutic strategies.
Further information can be found at Zaccolo Research Group.
Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2.
Zoccarato A. et al, (2015), Circ Res, 117, 707 - 719
cGMP signals modulate cAMP levels in a compartment-specific manner to regulate catecholamine-dependent signaling in cardiac myocytes.
Stangherlin A. et al, (2011), Circ Res, 108, 929 - 939
Protein kinase A type I and type II define distinct intracellular signaling compartments.
Di Benedetto G. et al, (2008), Circ Res, 103, 836 - 844
Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes.
Zaccolo M. and Pozzan T., (2002), Science, 295, 1711 - 1715
A genetically encoded, fluorescent indicator for cyclic AMP in living cells.
Zaccolo M. et al, (2000), Nat Cell Biol, 2, 25 - 29
PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling.
Monterisi S. et al, (2017), Elife, 6
FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility.
Surdo NC. et al, (2017), Nat Commun, 8
Components of the mitochondrial cAMP signalosome.
Monterisi S. and Zaccolo M., (2017), Biochem Soc Trans, 45, 269 - 274
Response to Wagner et al.: phosphodiesterase-2-anti-adrenergic friend or hypertrophic foe in heart disease?
Zoccarato A. et al, (2016), Naunyn Schmiedebergs Arch Pharmacol, 389, 1143 - 1145
Modulation of Compartmentalised Cyclic Nucleotide Signalling via Local Inhibition of Phosphodiesterase Activity.
Brescia M. and Zaccolo M., (2016), Int J Mol Sci, 17