Contact information
01865 272454
Research groups
Colleges
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Group Leader
Centre for Neural Circuits and Behaviour
Stephen F. Goodwin
BSc, MA, PhD
Professor of Neurogenetics
- Director of Graduate Studies
Genetic Dissection of Sexual Behaviour
Stephen studied genetics as an undergraduate at the University of Glasgow, and researched Drosophila learning and memory for his Ph.D. After a postdoctoral stint with Nobel laureate Jeffrey C. Hall at Brandeis University (USA), where he used molecular-genetic and behavioural approaches in the fruit fly to understand how the sexual identity of a nervous system and its behaviours are specified, he returned to the UK and spent 10 years leading a research group at the University of Glasgow. He arrived in Oxford in 2009, where he is a Professor of Neurogenetics, a Wellcome Trust Senior Investigator, and a Tutorial Fellow in Genetics at Magdalen College. He is part of the Centre for Neural Circuits and Behaviour along with the groups of Gero Miesenböck and Scott Waddell.
Stephen’s group uses the fruit fly, Drosophila melanogaster, to study the genetic, developmental, and neural mechanisms that underlie sex-specific behaviours in higher animals. In particular, the elaborate courtship ritual performed by the male fly has provided remarkable insights into how the neural circuitry underlying sexual behaviour, which is largely innate in flies, is built into the nervous system during development, and how this circuitry functions in the adult. The fly has the advantages of advanced molecular genetics approaches along with well-defined anatomy, physiology, and behaviour.
Key publications
Differential neuronal survival defines a novel axis of sexual dimorphism in the Drosophila brain.
Journal article
Allen AM. et al, (2026), Cell Genom
A high-resolution atlas of the brain predicts lineage and birth order underlying neuronal identity.
Journal article
Allen AM. et al, (2025), Cell Genom
Low-level repressive histone marks fine-tune gene transcription in neural stem cells.
Journal article
Rajan A. et al, (2023), Elife, 12
Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly.
Journal article
Li H. et al, (2022), Science, 375
Molecular Mechanisms of Sexually Dimorphic Nervous System Patterning in Flies and Worms.
Journal article
Goodwin SF. and Hobert O., (2021), Annu Rev Cell Dev Biol, 37, 519 - 547
Generation and characterization of fruitless P1 promoter mutant in Drosophila melanogaster.
Journal article
Neville MC. et al, (2021), J Neurogenet, 35, 285 - 294
A sex-specific switch between visual and olfactory inputs underlies adaptive sex differences in behavior.
Journal article
Nojima T. et al, (2021), Curr Biol, 31, 1175 - 1191.e6
A circuit logic for sexually shared and dimorphic aggressive behaviors in Drosophila.
Journal article
Chiu H. et al, (2021), Cell, 184, 507 - 520.e16
Distinct Roles and Synergistic Function of FruM Isoforms in Drosophila Olfactory Receptor Neurons.
Journal article
Zhang Y. et al, (2020), Cell Rep, 33
Ovipositor Extrusion Promotes the Transition from Courtship to Copulation and Signals Female Acceptance in Drosophila melanogaster.
Journal article
Mezzera C. et al, (2020), Curr Biol, 30, 3736 - 3748.e5
A single-cell transcriptomic atlas of the adult Drosophila ventral nerve cord.
Journal article
Allen AM. et al, (2020), Elife, 9
Interactions between the sexual identity of the nervous system and the social environment mediate lifespan in Drosophila melanogaster.
Journal article
Flintham EO. et al, (2018), Proc Biol Sci, 285
Sperm and sex peptide stimulate aggression in female Drosophila.
Journal article
Bath E. et al, (2017), Nat Ecol Evol, 1
Activation of Latent Courtship Circuitry in the Brain of Drosophila Females Induces Male-like Behaviors.
Journal article
Rezával C. et al, (2016), Curr Biol, 26, 2508 - 2515
Sex- and tissue-specific functions of Drosophila doublesex transcription factor target genes.
Journal article
Clough E. et al, (2014), Dev Cell, 31, 761 - 773
Sexually dimorphic octopaminergic neurons modulate female postmating behaviors in Drosophila.
Journal article
Rezával C. et al, (2014), Curr Biol, 24, 725 - 730
Male-specific fruitless isoforms target neurodevelopmental genes to specify a sexually dimorphic nervous system.
Journal article
Neville MC. et al, (2014), Curr Biol, 24, 229 - 241
Substrate-borne vibratory communication during courtship in Drosophila melanogaster.
Journal article
Fabre CCG. et al, (2012), Curr Biol, 22, 2180 - 2185
Neural circuitry underlying Drosophila female postmating behavioral responses.
Journal article
Rezával C. et al, (2012), Curr Biol, 22, 1155 - 1165
Control of sexual differentiation and behavior by the doublesex gene in Drosophila melanogaster.
Journal article
Rideout EJ. et al, (2010), Nat Neurosci, 13, 458 - 466
Recent publications
Differential neuronal survival defines a novel axis of sexual dimorphism in the Drosophila brain.
Journal article
Allen AM. et al, (2026), Cell Genom
A high-resolution atlas of the brain predicts lineage and birth order underlying neuronal identity.
Journal article
Allen AM. et al, (2025), Cell Genom
A High-Resolution Atlas of the Brain Predicts Lineage and Birth Order Underly Neuronal Identity
Preprint
Allen AM. et al, (2025)
A Role for Exaptation in Sculpting Sexually Dimorphic Brains from Shared Neural Lineages
Preprint
Allen AM. et al, (2025)
Dedicated developmental programing for group-supporting behaviors in eusocial honeybees.
Journal article
Sommer V. et al, (2024), Sci Adv, 10
Ovipositor Extrusion Promotes the Transition from Courtship to Copulation and Signals Female Acceptance in Drosophila melanogaster.
Journal article
Mezzera C. et al, (2023), Curr Biol, 33
Low-level repressive histone marks fine-tune gene transcription in neural stem cells.
Journal article
Rajan A. et al, (2023), Elife, 12
Low-level repressive histone marks fine-tune stemness gene transcription in neural stem cells
Preprint
Rajan A. et al, (2022)

