Postdoctoral Research Scientist
- Developing novel molecular targets for Parkinson's disease
I joined the Wade-Martins group in 2020 and have worked since to characterize the formation of the HDAC4/N-CoR/HDAC3 protein complex and its functional consequences in epigenetic gene repression, to gain insights into the underlying mechanisms of Parkinson’s disease; ultimately, to find a way to therapeutically intervene and stop the progression of the disease in an early stage.
I gained my scientific background in Biochemistry and Molecular Cell Biology at the Eötvös Loránd Science University in Budapest, where I obtained both my B.Sc. and M.Sc. degrees. I completed my PhD in collaboration with the Hungarian Academy of Sciences, Institute of Enzymology, where I studied the interactions of the protein TPPP/p25 (p25a). Particularly, I identified the interfaces of TPPP/p25 which bind its physiological partner tubulin and its pathological partner alpha-synuclein, in order to selectively inhibit the regions affected in neurodegenerative diseases.
New chemical tools for probing activity and inhibition of the NAD+-dependent lysine deacylase sirtuin 2.
Swyter S. et al, (2018), Philos Trans R Soc Lond B Biol Sci, 373
Modulation Of Microtubule Acetylation By The Interplay Of TPPP/p25, SIRT2 And New Anticancer Agents With Anti-SIRT2 Potency.
Szabó A. et al, (2017), Sci Rep, 7